Influence of distribution of lean body mass on resting metabolic rate after weight loss and weight regain: comparison of responses in white and black women

Byrne, Nuala M.; Weinsier, Roland L.; Hunter, Gary R.; Desmond, Reneé A.; Patterson, Mindy; Darnell, Betty E.; Zuckerman, Paul A.

doi:10.1093/ajcn/77.6.1368

Cited by 56 publications

(55 citation statements)

References 36 publications

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“…It has recently been shown that the distribution pattern of lean body mass influences RMR and could explain, at least in part, racial differences in RMR. 21 In fact, trunk lean body mass, reflecting a higher organ mass, has a higher energy expenditure than limb lean body mass. However, since, in this study, no measurement of lean body mass distribution was made, the potential role it plays in RMR and body weight change remains speculative.…”

Section: Discussionmentioning

confidence: 99%

Low relative resting metabolic rate and body weight gain in adult Caucasian Italians

et al. 2005

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OBJECTIVE: To investigate the relationship between resting metabolic rate (RMR) and subsequent changes in body size and degree of fatness in a group of adult Caucasian Italians. DESIGN: Prospective, longitudinal, observational study. SUBJECTS: In total, 155 subjects (72 males and 83 females, age range: 18-55 y; BMI: 17.5-63.4 kg/m 2 ) were evaluated. In total, 43 (26 m and 17 f; BMI: 28.971.1 kg/m 2 , mean7s.e.m.) of them were reassessed 10-12 y later. MEASUREMENTS: Anthropometric and body composition (bioimpedance analysis) parameters and RMR (indirect calorimetry) were taken at baseline and after 10-12 y. RESULTS: Subjects (15 m, 8 f) who gained body weight (arbitrarily defined as a change in body weight Z5 kg) had baseline BMI (29.971.8 vs 28.071.4; P ¼ NS) and body composition in terms of fat mass (FM%) and fat-free mass (FFM kg) comparable to those of the subjects (11 m, 9 f) whose body weight remained stable. Baseline RMR was significantly lower in subjects who gained weight than in those who did not (10872.1 vs 12273.1 kJ/kg-FFM 24 h; Po0.001), although it did not differ significantly between the two groups (11972 vs 12172 kJ/kg-FFM 24 h; P ¼ NS) 10-12 y later. Baseline RMR was inversely correlated to both change in body weight (r ¼ À0.57; Po0.001) and FM (r ¼ À0.50; Po0.001). CONCLUSION: A low RMR normalized for FFM appears to be associated with body weight gain in the long run in adult Caucasian Italians.

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Section: Discussionmentioning

confidence: 99%

Low relative resting metabolic rate and body weight gain in adult Caucasian Italians

et al. 2005

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“…A redistribution of skeletal muscle mass may occur with weight cycling. Byrne et al [32] found a preferential regain of lean soft tissue DXA at the limbs compared with the trunk in weight regaining obese African-American and white women and concluded that this might reflect a lower regain in high metabolically active organ mass (located at the trunk). Using whole body MRI, we could, however, show that it was the reconstitution of skeletal muscle at the trunk (not organ mass) that lagged behind the regain of the extremities [9 & ].…”

Section: Methodological Requirements Ii: Normalizing Changes In Fat Amentioning

confidence: 99%

Measuring the impact of weight cycling on body composition

Bosy‐Westphal

Müller

2014

Current Opinion in Clinical Nutrition and Metabolic Care

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“…In underweight women, the lower organ mass explained the lower REE adjusted for FFM compared with that in normal-weight subjects (23). Weight regain after weight loss may further reduce the specific metabolic rate of FFM, because trunk lean mass decreased with weight loss, but contrary to leg lean mass, it was not regained during weight regain (53). This may reflect a reduction in organ mass with weight cycling.…”

Section: Effect Of Weight Loss-associated Changes In Ffm Compositionmentioning

confidence: 95%

Contribution of individual organ mass loss to weight loss–associated decline in resting energy expenditure

Bosy‐Westphal

Kossel

Goele

et al. 2009

The American Journal of Clinical Nutrition

154

163

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Background: Weight loss leads to reduced resting energy expenditure (REE) independent of fat-free mass (FFM) and fat mass (FM) loss, but the effect of changes in FFM composition is unclear. Objective: We hypothesized that a decrease in REE adjusted for FFM with weight loss would be partly explained by a disproportionate loss in the high metabolic activity component of FFM. Design: Forty-five overweight and obese women [body mass index (in kg/m 2 ): 28.7-46.8] aged 22-46 y followed a low-calorie diet for 12.7 6 2.2 wk. Body composition was measured by magnetic resonance imaging, dual-energy X-ray absorptiometry, and a 4-compartment model. REE measured by indirect calorimetry (REEm) was compared with REE calculated from detailed body-composition analysis (REEc) by using specific organ metabolic rates (ie, organ REE/mass). Results: Weight loss was 9.5 6 3.4 kg (8.0 6 2.9 kg FM and 1.5 6 3.1 kg FFM). Decreases in REE (28%), free triiodothyronine concentrations (28%), muscle (23%), heart (25%), liver (24%), and kidney mass (26%) were observed (all P , 0.05). Relative loss in organ mass was significantly higher (P , 0.01) than was the change in low metabolically active FFM components (muscle, bone, and residual mass). After weight loss, REEm 2 REEc decreased from 0.24 6 0.58 to 0.01 6 0.44 MJ/d (P = 0.01) and correlated with the decrease in free triiodothyronine concentrations (r = 0.33, P , 0.05). Women with high adaptive thermogenesis (defined as REEm 2 REEc , 20.17 MJ/d) had less weight loss and conserved FFM, liver, and kidney mass. Conclusions: After weight loss, almost 50% of the decrease in REEm was explained by losses in FFM and FM. The variability in REEm explained by body composition increased to 60% by also considering the weight of individual organs.Am J Clin Nutr 2009;90:993-1001.

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Influence of distribution of lean body mass on resting metabolic rate after weight loss and weight regain: comparison of responses in white and black women

Abstract: In both races, trunk LBM decreased with weight loss and remained lower, despite significant weight regain, which potentially reflected decreased organ mass. Regional LBM distribution explained the racial difference in RMR.

Cited by 56 publications

References 36 publications

Low relative resting metabolic rate and body weight gain in adult Caucasian Italians

Low relative resting metabolic rate and body weight gain in adult Caucasian Italians

Measuring the impact of weight cycling on body composition

Contribution of individual organ mass loss to weight loss–associated decline in resting energy expenditure

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