Influence of diurnal phase on behavioral tests of sensorimotor performance, anxiety, learning and memory in mice

Tsao, Chi-Hui; Flint, Jonathan; Huang, Guo-Jen

doi:10.1038/s41598-021-03155-5

Cited by 24 publications

(8 citation statements)

References 26 publications

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“…Indeed, open field video-tracking revealed that distance traveled over time was elevated when 48 hr cycling animals were tested on days when they slept little (active days) compared to the alternating days of long sleep (inactive days) (Figures 2F-I). In contrast, no difference was found in Meth-naïve animals, when tested during their corresponding active (ZT12-18) and inactive (ZT0-6) phases in line with previous findings 20 (Figures 2K and 2L). Notably, distance traveled on active days in 48 hr cyclers was also greater when compared to Meth-naïve mice (Figure 2M), while there was no difference between inactive days and Meth-naïve animals (Figure 2N).…”

Section: Resultssupporting

confidence: 92%

The neurons that drive infradian sleep-wake and mania-like behavioral rhythms

Markam,

Bourguignon,

Zhu

et al. 2023

Preprint

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SummaryInfradian mood and sleep-wake rhythms with periods of 48 hr and beyond have been observed in bipolar disorder (BD) subjects that even persist in time isolation, indicating an endogenous origin. Here we show that mice exposed to methamphetamine (Meth) in drinking water develop infradian locomotor rhythms with periods of 48 hr and beyond which extend to sleep length and mania-like behaviors in support of a model for cycling in BD. This cycling capacity is abrogated upon genetic disruption of DA production in DA neurons of the ventral tegmental area (VTA) or ablation of nucleus accumbens (NAc) projecting, dopamine (DA) neurons. Chemogenetic activation of NAc-projecting DA neurons leads to locomotor period lengthening in clock deficient mice, while cytosolic calcium in DA processes of the NAc was found fluctuating synchronously with locomotor behavior. Together, our findings argue that BD cycling relies on infradian rhythm generation that depends on NAc-projecting DA neurons.

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Section: Resultssupporting

confidence: 92%

The neurons that drive infradian sleep-wake and mania-like behavioral rhythms

Markam,

Bourguignon,

Zhu

et al. 2023

Preprint

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“…The estrous stage, however, did not affect anxiety-like behavior in females assessed during the light period. Even though studies revealed mixed outcomes on the effect of daytime on anxiety-like behaviors ( Richetto et al, 2018 ; Meseguer Henarejos et al, 2020 ; Tsao et al, 2022 ), our results strongly support the view that time of day is a major factor in the regulation of anxiety-like behavior, and the deletion of clock genes in the striatum appears to attenuate this effect.…”

Section: Discussionsupporting

confidence: 81%

Characterization of Affective Behaviors and Motor Functions in Mice With a Striatal-Specific Deletion of Bmal1 and Per2

Schöttner

Alonso²,

Button³

et al. 2022

Front. Physiol.

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The expression of circadian clock genes, either centrally or in the periphery, has been shown to play an integral role in the control of behavior. Brain region-specific downregulation of clock genes revealed behavioral phenotypes associated with neuropsychiatric disorders and neurodegenerative disease. The specific function of the clock genes as well as the underlying mechanisms that contribute to the observed phenotypes, however, are not yet fully understood. We assessed anxiety- and depressive-like behavior and motor functions in male and female mice with a conditional ablation of Bmal1 or Per2 from medium spiny neurons (MSNs) of the striatum as well as mice lacking one copy of Gpr88. Whereas the conditional knockout of Bmal1 and Per2 had mild effects on affective behaviors, a pronounced effect on motor functions was found in Bmal1 knockout mice. Subsequent investigation revealed an attenuated response of Bmal1 knockout mice to dopamine receptor type 1 agonist treatment, independently of the expression of targets of the dopamine signaling pathway or mitochondrial respiration in MSNs. The study thus suggests a potential interaction of Bmal1 within the direct dopamine signaling pathway, which may provide the link to a shared, MSN-dependent mechanism regulating affective behavior and motor function in mice.

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“…In mice kept in LD, the number of correct alternations in the Y-maze, which is dependent on hippocampal plasticity and related to exploratory activity [37], was significantly lower in the light phase than in the dark phase. This is consistent with the suppressive effect of light on activity in nocturnal animals [4], differences in effects of light and dark phase testing on behavioral readouts [42,43], and inhibition of behavioral and cognitive performance in the light phase [44] in mice. In contrast, when the mice were kept in DD to unmask circadian rhythms, there was no difference in the number of correct alternations in the Y-maze, although rhythmic spontaneous locomotor activity persisted.…”

Section: Effect Of Light/dark Cyclesupporting

confidence: 84%

Effects of the Light/Dark Phase and Constant Light on Spatial Working Memory and Spine Plasticity in the Mouse Hippocampus

Schröder,

Abdel-Hafiz,

Ali

et al. 2023

Cells

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Circadian rhythms in behavior and physiology such as rest/activity and hormones are driven by an internal clock and persist in the absence of rhythmic environmental cues. However, the period and phase of the internal clock are entrained by the environmental light/dark cycle. Consequently, aberrant lighting conditions, which are increasing in modern society, have a strong impact on rhythmic body and brain functions. Mice were exposed to three different lighting conditions, 12 h light/12 h dark cycle (LD), constant darkness (DD), and constant light (LL), to study the effects of the light/dark cycle and aberrant lighting on the hippocampus, a critical structure for temporal and spatial memory formation and navigation. Locomotor activity and plasma corticosterone levels were analyzed as readouts for circadian rhythms. Spatial working memory via Y-maze, spine morphology of Golgi–Cox-stained hippocampi, and plasticity of excitatory synapses, measured by number and size of synaptopodin and GluR1-immunreactive clusters, were analyzed. Our results indicate that the light/dark cycle drives diurnal differences in synaptic plasticity in hippocampus. Moreover, spatial working memory, spine density, and size and number of synaptopodin and GluR1 clusters were reduced in LL, while corticosterone levels were increased. This indicates that acute constant light affects hippocampal function and synaptic plasticity.

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Influence of diurnal phase on behavioral tests of sensorimotor performance, anxiety, learning and memory in mice

Cited by 24 publications

References 26 publications

The neurons that drive infradian sleep-wake and mania-like behavioral rhythms

The neurons that drive infradian sleep-wake and mania-like behavioral rhythms

Characterization of Affective Behaviors and Motor Functions in Mice With a Striatal-Specific Deletion of Bmal1 and Per2

Effects of the Light/Dark Phase and Constant Light on Spatial Working Memory and Spine Plasticity in the Mouse Hippocampus

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