Influence of Donor Age on Renal Graft Function in First Seven Post Transplant Days

Abstract

Increasing gap between demand and availability of human kidneys for transplantation has forced a re-evaluation of the limits on donor age acceptability. e present study included  patients who underwent kidney transplantation in University Clinical Centre Tuzla. In an observational cohort study we assessed impact of donor age on post transplant renal function by analyzing following parameters:  hour urine output, creatinine clearance (Cr Cl) and glomerular fi ltration rate (GFR). Depending on donor age recipients were allocated in to two groups. Group I included patients who received renal graft from donors age up to  years, and Group II encountered recipients who received renal graft from donors older than  years. Our goal was to determine whether donor age over  years signifi cantly diminishes renal graft function in fi rst seven post transplant days. No statistically signifi cant diff erence was found between Group I and II regarding  hour urine output. From second to fi fth postoperative day creatinine clearance values were higher in the group of patients who received kidney from donors older than  years (±,  vs. , ±, ). On the fi fth, sixth and seventh post operative day GFR was signifi cantly higher in patients who received renal graft from donors age up to  years (p<, ). Our data showed no signifi cant diff erence in observed variables between the two groups, thus indicating that utilization of renal grafts from donors' age >  years is acceptable and may considerably expand the donor pool.

Factors associated with long‐term graft survival in pediatric kidney transplant recipients

“…Results from previous studies, which have found that patients who receive kidneys from older donors carry a higher risk for graft failure, were not replicated in this study, which showed that grafts from older donors had a similar rate of survival as those from younger donors 22,23 …”

“…Results from previous studies, which have found that patients who receive kidneys from older donors carry a higher risk for graft failure, were not replicated in this study, which showed that grafts from older donors had a similar rate of survival as those from younger donors. 22,23 This study found that a recipient weight between 10 and 20 kg was protective for graft survival. No past studies explicitly describe the effects of recipient weight on graft survival in pediatric recipients, possibly because it may be collinear with age.…”

Terlipressin reduces the incidence of delayed graft function in kidney transplant recipients

“…Helanterä et al con rmed recently that donor age is an independent risk factor for DGF [31]. In contrast, Imamovic et al showed that donor age had no effect on allograft function in the rst seven days after transplantation [32]. Our results show that the donor age was negatively correlated with allograft function 30 days after transplantation.…”

Böbrek Nakli Olan Hastalarda Nakil Sonrasında Oluşan Anti-HLA Antikorlarının Saptanması ve Çeşitli Parametrelerle İlişkisinin Değerlendirilmesi

“…Imamovic et al reported that the association between GFR, age, creatinine, and creatinine clearance was also statistically significant. Mean creatinine levels of patients transplanted from alive and deceased donor were compared (13). Although the results were not significant due to our limited number of patients (p>0.05), creatinine levels of patients transplanted from deceased donor were higher than the others.…”