Influence of donor base deficit status on recipient outcomes in liver transplantation

delaTorre, Andrew; Kuo, Paul C.; Plotkin, Jeffrey S.; Ridge, Linda; Howell, Charles D.; Bartlett, S. T.; Johnson, Lynt B.

doi:10.1016/s0041-1345(96)00627-6

Cited by 12 publications

(4 citation statements)

References 4 publications

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“…Hemodynamic compromise often is the result of severe cerebral edema or brain death. Donor hypotension has been associated with reduced liver allograft function and increased recipient length of stay in retrospective analyses (283)(284)(285), so the mean arterial blood pressure should be kept at or above 60 -70 mm Hg (286). Pressors are commonly used in potential organ donors.…”

Section: Recommendationmentioning

confidence: 99%

Management of the Potential Organ Donor in the ICU

Kotloff

Blosser

Fulda

et al. 2015

Critical Care Medicine

279

150

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This document was developed through the collaborative efforts of the Society of Critical Care Medicine, the American College of Chest Physicians, and the Association of Organ Procurement Organizations. Under the auspices of these societies, a multidisciplinary, multi-institutional task force was convened, incorporating expertise in critical care medicine, organ donor management, and transplantation. Members of the task force were divided into 13 subcommittees, each focused on one of the following general or organ-specific areas: death determination using neurologic criteria, donation after circulatory death determination, authorization process, general contraindications to donation, hemodynamic management, endocrine dysfunction and hormone replacement therapy, pediatric donor management, cardiac donation, lung donation, liver donation, kidney donation, small bowel donation, and pancreas donation. Subcommittees were charged with generating a series of management-related questions related to their topic. For each question, subcommittees provided a summary of relevant literature and specific recommendations. The specific recommendations were approved by all members of the task force and then assembled into a complete document. Because the available literature was overwhelmingly comprised of observational studies and case series, representing low-quality evidence, a decision was made that the document would assume the form of a consensus statement rather than a formally graded guideline. The goal of this document is to provide critical care practitioners with essential information and practical recommendations related to management of the potential organ donor, based on the available literature and expert consensus.

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Section: Recommendationmentioning

confidence: 99%

Management of the Potential Organ Donor in the ICU

Kotloff

Blosser

Fulda

et al. 2015

Critical Care Medicine

279

150

View full text Add to dashboard Cite

show abstract

“…Maring et al 2 Greig et al 6 Mimeault et al 8 Ploeg et al 9 Figueras et al 10 Briceno et al 12 Yersiz et al 13 Busquets et al 14 Kizilisik et al 15 Lee et al 16 Jonas et al 17 Gonzalez et al 18 Retrospective 19 Briceno et al 20 Verran et al 21 Oh et al 22 Gruenberger et al 23 Totsuka et al 24 Makowka et al 26 delaTorre et al 27 Retrospective, consecutive Table 2 Continued Abbreviations: BP, hypotension (criteria vary among studies); CIT, cold ischemia time; CPR, cardiopulmonary resuscitation; DS, vasoactive drug(s) support (criteria vary among studies); DX, cause of donor death; EC, Euro-Collins solution; fat, liver steatosis; ICH, intracerebral hemorrhage; IPF, initial poor function; LFT, liver function tests (includes hepatocellular enzymes, bilirubin, prothrombin time, fibrinogen, bile production); LOS, length of stay; Na, sodium or hypernatremia; PNF, primary nonfunction; TBI, traumatic brain injury; UW, University of Wisconsin solution; WIT, warm ischemia time; +correl, the listed factor is associated with a worsening in some outcome measure.…”

Section: Pownermentioning

confidence: 99%

Factors during Donor Care That May Affect Liver Transplantation Outcome

Powner

2004

Prog Transpl

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Publications are reviewed that identify factors during donor care and characteristics of the donor liver that may be associated with outcome following liver transplantation. The procurement coordinator has the opportunity to influence cold ischemia time, blood pressure, the serum sodium concentration and, perhaps, liver glycogen reserves. These variables may significantly affect postimplantation graft performance and graft or recipient survival. Summaries of those publications comprising this database are presented, and several limitations in their interpretation are discussed.

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“…Los períodos de hipotensión en el donante con muerte cerebral se han asociado con reducción de la función del injerto hepático y aumento de la estancia hospitalaria del receptor, en estudios retrospectivos 74,75 . Además, el uso de altas dosis de vasopresores en el potencial donante hepático predisponen a lesión hepática isquémica; no obstante, su administración no contraindica el uso del órgano para trasplante 18,76,77 .…”

Section: Cambios Hepáticosunclassified