1970
DOI: 10.1161/01.res.27.2.213
|View full text |Cite
|
Sign up to set email alerts
|

Influence of Duration of Cholesterol Feeding on Esterification of Fatty Acids by Cell-Free Preparation of Pigeon Aorta

Abstract: Influence of duration of cholesterol feeding on esterification of fatty acids and hydrolysis of cholesteryl esters was studied in cell-free preparations of aorta from White Cameau pigeons. Esterification of fatty acids required ATP and CoA; greater than 80* of the esterifying activity was located in the particulate fraction obtained by centrifugation at 105,000 X g (after a preliminary centrifugarion at 1000 X g). Fatty acids were incorporated most efficiently into phospholipid, primarily (82%) lecithin. Great… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
6
0

Year Published

1977
1977
2010
2010

Publication Types

Select...
4
2
1

Relationship

0
7

Authors

Journals

citations
Cited by 110 publications
(6 citation statements)
references
References 25 publications
0
6
0
Order By: Relevance
“…The development of atherosclerosis is the result of changes in arterial walls. Cholesteryl ester (CE) concentration is a strong indicator of the development of atherosclerosis because it is one of the first metabolic compounds to occur at the intima in diseased arteries (St. Clair and others 1970). The CE concentration can increase as much as seventy times in atherosclerotic arteries compared to healthy arteries (St. Clair and others 1970; Day and Proudlock 1974).…”
Section: Introductionmentioning
confidence: 99%
“…The development of atherosclerosis is the result of changes in arterial walls. Cholesteryl ester (CE) concentration is a strong indicator of the development of atherosclerosis because it is one of the first metabolic compounds to occur at the intima in diseased arteries (St. Clair and others 1970). The CE concentration can increase as much as seventy times in atherosclerotic arteries compared to healthy arteries (St. Clair and others 1970; Day and Proudlock 1974).…”
Section: Introductionmentioning
confidence: 99%
“…27 Atherosclerotic arterial tissue, however, accumulates cholesteryl esters rich in oleic acid, 28 suggestive of newly esterified cholesterol. 3 - 29 Thus, in the atherosclerotic artery, the binding and degradation of plasma lipoproteins by arterial smooth muscle cells appears to proceed normally, as does the stimulation of cholesterol esterification. The removal of these newly synthesized cholesteryl esters, however, appears to proceed at a rate insufficient to handle those that are being synthesized.…”
Section: Discussionmentioning
confidence: 99%
“…This suggests that an alteration of cholesteryl ester metabolism may play a role in the initial events in the pathogenesis of atherosclerosis. 3 Consistent with this hypothesis is the fact that a stimulation of cholesterol esterification can be demonstrated in arterial tissue prior to the appearance of grossly visible atherosclerotic lesions. 3 ' 4 These changes in cholesterol esterification correlate well with changes in the cholesteryl ester content of the atherosclerotic artery.…”
mentioning
confidence: 82%
See 2 more Smart Citations