Influence of Duration of Diabetes Mellitus, Glycemic Control, and Traditional Cardiovascular Risk Factors on Abdominal Aortic Diameter in Older Adults with Type 2 Diabetes Mellitus

Amer, Moatassem S.; Rahman, Tomader Taha Abdel; Omar, Omar; Reda, Randa; Ali, D.

doi:10.1111/j.1532-5415.2011.03459.x

Cited by 1 publication

(1 citation statement)

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“…We were unable to detect abnormalities in aortic diameter or carotid stiffness or diameter, suggesting that the decrease in TAC seen in type 2 diabetes is purely the result of aortic wall stiffening. Although we only assessed the aortic root, other studies have similarly failed to show smaller distal aortic segments in type 2 diabetes (21,27,28). …”

Section: Discussionmentioning

confidence: 99%

Central Pulse Pressure and Its Hemodynamic Determinants in Middle-Aged Adults With Impaired Fasting Glucose and Diabetes

et al. 2013

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OBJECTIVEPulse pressure (PP), a strong predictor of cardiovascular events in type 2 diabetes, is a composite measure affected by several hemodynamic factors. Little is known about the hemodynamic determinants of central PP in type 2 diabetes or whether abnormalities in central pulsatile hemodynamics are already present in individuals with impaired fasting glucose (IFG). In a population-based study, we aimed to compare central PP and its hemodynamic determinants among adults with normal fasting glucose (n = 1654), IFG (n = 240), and type 2 diabetes (n = 33).RESEARCH DESIGN AND METHODSWe measured carotid pressure, left ventricular outflow, aortic root diameter, carotid artery flow, and distension in order to measure various structural and hemodynamic arterial parameters.RESULTSIFG was associated with a greater mean arterial pressure (MAP) but was not associated with intrinsic aortic stiffening or abnormal aortic pulsatile indices after adjustment for MAP. After adjustment for age, sex, and MAP, type 2 diabetes was associated with a higher aortic root characteristic impedance (Zc), aortic root elastance-thickness product (Eh), and aortic root pulse wave velocity (but not aortic root diameter), a greater carotid-femoral pulse wave velocity, and lower total arterial compliance and wave reflection magnitude. Carotid size, Zc, distensibility, or Eh did not significantly differ between the groups.CONCLUSIONSType 2 diabetes, but not IFG, is associated with greater large artery stiffness, without abnormalities in aortic root diameter or carotid stiffness. Subjects with type 2 diabetes demonstrate a decreased reflection magnitude, which may indicate an increased penetration of pulsatile energy to distal vascular beds.

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Section: Discussionmentioning

confidence: 99%