Influence of Dyslipidemia and Diabetes Mellitus on Chronic Periodontal Disease

Abdo, Juliane Almeida; Cirano, Fabiano Ribeiro; Casati, Márcio Zaffalon; Ribeiro, Fernanda Vieira; Giampaoli, Viviana; Casarin, Renato Corrêa Viana; Pimentel, Suzana Peres

doi:10.1902/jop.2012.120366

Cited by 29 publications

(20 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies have reported incidence and progression of periodontal disease in patients with DMt2 in Brazil; 18–20 however, none of them evaluated the effects of chronic periodontal disease progression on DM outcomes. It is deemed important to evaluate patients from a specific geographic area with low socioeconomic and educational status who receive medical treatment from the public health care system, in which the majority of patients with DM and those presenting periodontal disease seek treatment 21 .…”

mentioning

confidence: 99%

Influence of Periodontal Disease on Changes of Glycated Hemoglobin Levels in Patients With Type 2 Diabetes Mellitus: A Retrospective Cohort Study

Costa

Taboza

Angelino

et al. 2017

Journal of Periodontology

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

Influence of Periodontal Disease on Changes of Glycated Hemoglobin Levels in Patients With Type 2 Diabetes Mellitus: A Retrospective Cohort Study

Costa

Taboza

Angelino

et al. 2017

Journal of Periodontology

View full text Add to dashboard Cite

show abstract

“…[9] showed that TC was significantly increased in patients with Type II DM; however, periodontal disease did not show any significant correlation. The results of this study are contrary to the findings of our study regarding periodontal diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown that Type II DM is positively correlated with hyperlipidemia and periodontitis does not show a definite association;[9] however, other studies have shown a positive association between periodontitis and hyperlipidemia. [1011]…”

Section: Introductionmentioning

confidence: 99%

Comparative evaluation of the lipid profile in the serum of patients with type II diabetes mellitus and healthy individuals with periodontitis

et al. 2017

View full text Add to dashboard Cite

Context:Periodontal disease is an immuno-inflammatory disease that is initiated by the interaction between microbial plaque and the periodontal tissues. The data available on the association of periodontal diseases with the lipid profile are conflicting. Therefore, a need for a study in this area was felt.Aims:To evaluate the lipid profile in the serum of patients with chronic periodontitis and chronic periodontitis with Type II diabetes mellitus (DM) patients and to compare it with healthy controls, to see whether they can serve as potential markers for chronic periodontitis and also to assess whether periodontitis can have systemic effects.Settings and Design:This study is a cross-sectional study.Subjects and Methods:This cross-sectional study was conducted involving 300 participants in the age group of 30–60 years from October 2010 to May 2015. Five milliliters of venous blood was collected from each of the study participants, from the antecubital vein. Lipid profile was assessed using the ERBA commercially available kit.Statistical Analysis:Statistical analysis was carried out using SPSS software version 17. Multigroup comparison was carried out using ANOVA. The honest significant difference Tukey's test was used in conjunction with ANOVA to find means which are significantly different from each other.Results:When the lipid profile was estimated, total cholesterol (TC) levels were seen to be significantly higher (P < 0.001) in the DM with periodontitis group. High-density lipoprotein (HDL) levels were seen to be significantly higher (P < 0.001) in the control group. Mean serum low-density lipoprotein (LDL) and very LDL (VLDL) levels were seen to be significantly higher (P < 0.001) in the DM with periodontitis group. The triglyceride (TGL) values were also significantly higher (P < 0.001) in the DM with periodontitis group. The HDL and LDL levels were seen to be nonsignificant between chronic periodontitis and chronic periodontitis with diabetic group.Conclusions:The findings of the study showed that the lipid profile was significantly altered in patients with chronic periodontitis as compared to healthy controls. There was a potentiated difference in the values for TC, VLDL cholesterol, and TGL in patients with chronic periodontitis when compared to patients with Type II DM. HDL cholesterol and LDL cholesterol did not show a significant difference.

show abstract

“…STZ has highly selective toxic effects on islet cells in experimental animals, which leads to direct destruction of pancreatic β cells of the islet tissue or causes an immune response and decreases the insulin secretion of islets, which leads to diabetes (14,15). This model has advantages, including a simple preparation method, low dosage, low toxicity and specific islet cell damage, and it has become the preferred method of establishing a rat model of diabetes (16).…”

Section: Discussionmentioning

confidence: 99%

Effect of β-anhydroicaritin on the expression levels of tumor necrosis factor-α and matrix metalloproteinase-3 in periodontal tissue of diabetic rats

Wang

2015

Molecular Medicine Reports

View full text Add to dashboard Cite

The present study aimed to investigate the effect of β-anhydroicaritin on the expression levels of tumor necrosis factor (TNF)-α and matrix metalloproteinase (MMP)-3, and the pathological changes in the periodontal tissue of diabetic rats. Male Wistar rats (n=40; three months old) were randomly divided into four groups: Normal control group, diabetes group, diabetes + β-anhydroicaritin group and diabetes + urate group, (n=10 in each group). Following an overnight fast, diabetes was induced by intraperitoneal injection of streptozocin. The rats were maintained for 12 weeks and the blood sugar, urine sugar and body weight were assessed in week 12. Histological changes of the periodontal tissues were observed by hematoxylin and eosin staining, and the expression levels of TNF-α and MMP-3 were observed by immunohistochemistry. Following 12 weeks, the TNF-α grey value in the diabetes group was significantly lower compared with that in the control group (P<0.05), while no significant difference was observed between TNF-α levels in the diabetes + β-anhydroicaritin group, diabetes + urate group and the control group (P>0.05). However, TNF-α levels in the diabetes + β-anhdroicaritin group and diabetes + urate group were significantly higher compared with those in the diabetes group (P<0.05), and those in the diabetes + β-anhydroicaritin group were lower compared with those in the diabetes + urate group (P<0.05). The MMP-3 grey value in the diabetes group was significantly lower compared with that in the control group (P<0.05), while no significant difference was observed between MMP-3 levels in the diabetes + β-anhydroicaritin group, diabetes + urate group and the control group (P>0.05). However, MMP-3 levels the diabetes + β-anhydroicaritin group and diabetes + urate group were significantly higher compared with those in the diabetes group (P<0.05), and those in the diabetes + β-anhydroicaritin group were lower compared with those in the diabetes + urate group (P<0.01). β-anhydroicaritin normalized the expression levels of TNF-α and MMP-3 in the periodontal tissue of diabetic rats and led to the recovery of the changes in the morphological structure of the periodontal tissue.

show abstract

Influence of Dyslipidemia and Diabetes Mellitus on Chronic Periodontal Disease

Abstract: It could be concluded that dyslipidemia did not influence periodontal conditions in participants with normal health or those with DM2. However, age, smoking habits, and especially DM2 were significantly associated with loss of CAL.

Cited by 29 publications

References 44 publications

Influence of Periodontal Disease on Changes of Glycated Hemoglobin Levels in Patients With Type 2 Diabetes Mellitus: A Retrospective Cohort Study

Influence of Periodontal Disease on Changes of Glycated Hemoglobin Levels in Patients With Type 2 Diabetes Mellitus: A Retrospective Cohort Study

Comparative evaluation of the lipid profile in the serum of patients with type II diabetes mellitus and healthy individuals with periodontitis

Effect of β-anhydroicaritin on the expression levels of tumor necrosis factor-α and matrix metalloproteinase-3 in periodontal tissue of diabetic rats

Contact Info

Product

Resources

About