Influence of early neonatal experience on nociceptive responses and analgesic effects in rats

Dickinson, Amy L; Leach, Matthew C.; Flecknell, P. A.

doi:10.1258/la.2007.007078

Cited by 26 publications

(13 citation statements)

References 27 publications

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“…There is accumulated evidence that stressful early life experiences can affect brain development and subsequent adult behaviour (Aisa et al, 2009; Dickinson, Leach, & Flecknell, 2009; Grunau et al, 2009; Luecken, Kraft, Appelhans, & Enders, 2009). Although the underlying mechanisms for these effects are still poorly understood, it seems clear that in humans similar environmentally‐induced changes could be core factors in the aetiology of psychiatric disorders (McEwen, 2008).…”

Section: Discussionmentioning

confidence: 99%

Irritant‐drinking behaviour can be modified by gravity‐stress loaded in developing but not in adult rats

2011

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It is generally accepted that taste and taste‐related trigeminal chemical sensation bring up emotions that are essential for animal living and for a good quality of life, and that stress may modify sensory systems related to emotionality. The purpose of this study was to clarify (1) the effects of stress on taste and trigeminal irritant sensations, (2) effects of stress at a developing stage on these sensations. Male Wistar albino rats received 1G, 2G or 3G stimulation. Hyper‐gravity was applied with a centrifugal apparatus. The two‐bottle preference test was performed to measure chemical sensation. Adult rats received 1G (control), 2G (moderate) or 3G (strong) gravity loading every 10 min/day during 32 days. Developing rats received 3G gravity loading every 10 min/day during 45 days and were compared with 1G controls. As test solutions, taste solutions (sucrose, saccharin, citric acid, NaCl, monosodium glutamate, quinine and caffeine) and a trigeminal irritant solution (capsaicin) were used. In developing rats, but not in adult rats, hyper‐gravity stimulation increased the intake volume of sucrose, saccharin, NaCl, quinine and capsaicin, and the preference ratio for quinine, caffeine and capsaicin. It is suggested that the life stage where stress is loaded is critical for determining changes in emotionality as well as in emotion‐related sensory systems. Copyright © 2010 John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 99%

Irritant‐drinking behaviour can be modified by gravity‐stress loaded in developing but not in adult rats

2011

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“…Of particular relevance to the developmental theory of SP are studies which demonstrate that early maternal separation in rats changes nociception and analgesia (59-61), decreases the number of brain opioid receptors (61) and reduces opioid effects during pain (62); increases susceptibility to infection (63), to stress-related gastric ulcers (64) and to high blood pressure (65); increases reactivity to stress (66, 67), reduces GABA-A receptor levels in the medial prefrontal cortex and in noradrenergic cell body regions of the locus coeruleus and the nucleus tractus solitarius (68), and decreases growth hormone factor (69). Studies show that maternal separation causes acute changes in an infant rat's physiology and behavior which are not simply expressions of an infant's stress response but rather reflect the loss of specific physiological and behavioral mother-infant regulatory interactions.…”

Section: Multidisciplinary Research Findingsmentioning

confidence: 99%

Somatoform Pain

Landa

Peterson

Fallon

2012

Psychosomatic Medicine

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Somatoform pain is a highly prevalent, debilitating condition and a tremendous public health problem. Effective treatments for somatoform pain are urgently needed. The etiology of this condition is, however, still unknown. On the basis of a review of recent basic and clinical research, we propose one potential mechanisms of symptom formation in somatoform pain and a developmental theory of its pathogenesis. The emerging evidence from animal and human studies in developmental neurobiology, cognitive-affective neuroscience, psychoneuroimmunology, genetics, epigenetics, and clinical and treatment studies of somatoform pain all point to the existence of a shared physical and social pain neural system. Research findings also show that non-optimal early experiences interact with genetic predispositions to influence the development of this shared system and ability to regulate it in an effective way. Interpersonal affect regulation between infant and caregiver is crucial for the optimal development of these brain circuits. The aberrant development of this shared neural system during infancy, childhood and adolescence, therefore, may ultimately lead to an increased sensitivity to physical and social pain and to problems with their regulation in adulthood. The authors critically review translational research findings that support this theory and discuss its clinical and research implications. Specifically, the proposed theory and reviewed research suggest that psychotherapeutic and/or pharmacologic interventions that foster the development of affect regulation capacities in an interpersonal context will also serve to more effectively modulate aberrantly activated neural pain circuits and thus be of particular benefit in the treatment of somatoform pain.

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“…Also, in rats changes in nociception and emotional behaviour have been reported after fostering pups to a different dam (Malkesman et al . 2008; Dickinson et al . 2009).…”

Section: Introductionmentioning

confidence: 99%

Fostering in mice induces cardiovascular and metabolic dysfunction in adulthood

Matthews

Samuelsson

Seed

et al. 2011

The Journal of Physiology

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Non-technical summary Cross-fostering of newborn pups to different dams is a method widely used in rodent studies of developmental 'programming' to determine whether pregnancy or the suckling period is more important in determining adult characteristics following changes to the maternal environment. We have investigated whether the process of fostering per se influences cardiovascular and metabolic development in mice. Compared with mice reared by their biological mother, fostered mice showed increased appetite, body weight, abdominal fatness and altered blood sugar metabolism. A marked increase in blood pressure was also apparent. This study demonstrates that the process of fostering can lead to profound effects in cardiovascular and metabolic function in otherwise normal mice. The findings have implications both for the interpretation of previous cross-fostering studies in mice and for studies investigating the hypothesis of developmental programming, in which early postnatal manipulation of litters is common practice.Abstract Cross-fostering is widely used in developmental programming studies to determine the relative contribution of the in utero and suckling periods in establishing the adult offspring phenotype in response to an environmental challenge. We have investigated whether the process of fostering per se influences cardiovascular and metabolic function in adult offspring of C57BL/6J mice in comparison with animals suckled by their biological dams. Cross-fostered (CF) mice demonstrated juvenile onset hyperphagia and significantly higher body weight (from weaning to 12 weeks: male control (CON) vs. CF: P < 0.01, female CON vs. CF: P < 0.001; RM ANOVA) accompanied by increased abdominal adiposity in males only (white adipose tissue mass (mg): CON 280.5 ± 13.4 [mean ± SEM] (n = 7) vs. CF, 549.8 ± 99.3 (n = 8), P < 0.01). Both male and female CF mice demonstrated significantly enhanced glucose tolerance. A marked increase in systolic blood pressure (SBP) was observed in male CF mice (SBP (mmHg), day: CON 100.5 ± 1.4 (n = 6) vs. CF 114.3 ± 0.7 (n = 6), P < 0.001; night: CON 108.0 ± 2.0 (n = 6) vs. CF 123.2 ± 1.1 (n = 6), P < 0.001). Endothelium-dependent relaxation was enhanced in male CF mice, and renal noradrenaline was increased in female CF mice. Concentration of serum triglycerides, cholesterol, insulin and leptin were increased in CF vs. CON. The process of cross-fostering profoundly affects cardiovascular and metabolic phenotype in mice. The findings have implications for the inclusion of appropriate controls in the design of future studies and in the interpretation of previous cross-fostering studies in mice.

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Influence of early neonatal experience on nociceptive responses and analgesic effects in rats

Cited by 26 publications

References 27 publications

Irritant‐drinking behaviour can be modified by gravity‐stress loaded in developing but not in adult rats

Irritant‐drinking behaviour can be modified by gravity‐stress loaded in developing but not in adult rats

Somatoform Pain

Fostering in mice induces cardiovascular and metabolic dysfunction in adulthood

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