Influence of Ectromelia virus (ECTV-Mos) infection on mRNA transcript levels of selected genes encoding antiviral proteins in a macrophage cell line RAW 264.7 (in vitro studies).
Abstract:Poxviruses have evolved a number of mechanisms to avoid immune response by the infected host. We investigated the impact of poxvirus infection on the level of mRNA transcripts of selected genes encoding antiviral proteins in the macrophage cell line (RAW 264.7). We observed reduction of mRNA transcript level in four groups of signalling pathways (Toll-like receptor signalling, NOD-like receptor signalling, RIG-I-like receptor signalling, and Type I interferon signalling) involved in innate immune response. Sev… Show more
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