Influence of ejaculatory abstinence period on semen quality of 5165 normozoospermic and oligozoospermic Nigerian men: A retrospective study

Akhigbe, R.E.; Hamed, Moses Agbomhere; Dutta, Sulagna; Sengupta, Pallav

doi:10.1002/hsr2.722

Cited by 8 publications

(6 citation statements)

References 35 publications

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“…The observed decline in sperm quality has wider implications beyond male fertility. Studies have linked low semen quality with socio-economic challenges ( 3 , 14 ) and overall morbidity and mortality. Thus the observed decline in semen quality may exert ripple effects across the male lifespan.…”

Section: Discussionmentioning

confidence: 99%

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Impact of organophosphate pesticides exposure on human semen parameters and testosterone: a systematic review and meta-analysis

Hamed,

Akhigbe,

Adeogun

et al. 2023

Front. Endocrinol.

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BackgroundOrganophosphate (OP) pesticides have been associated with a decline in semen quality, although there are still considerable arguments about the magnitude of the association.ObjectiveThis study provides a systematic review and meta-analysis of the impacts of OP pesticides on semen quality and male reproductive hormones.MethodsThis study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocols. Strategic search was conducted using combined text words as search terms. The eligibility criteria were developed based on Population, Exposure, Comparator, Outcome, and Study designs (PECOS) framework. Relevant data were extracted, risk of bias was evaluated by The Office of Health Assessment and Translation (OHAT) tool, and certainty of evidence was assessed by the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group guidelines. Quantitative meta-analysis was performed by using Review Manager.ResultsA total of 766 male subjects (349 exposed to OP pesticides and 417 unexposed controls) were included in the meta-analysis. There was no significant difference in the ejaculate volume, seminal fluid volume, sperm multiple anomaly index, sperm, and leukocytes levels of the OP-exposed subjects compared to the control. In addition, OP pesticides exposure did not significantly affect serum concentrations of FSH, LH, and testosterone in subjects who were exposed to OP pesticides compared to their unexposed counterparts. However, we found a significant reduction in the sperm count, sperm concentration, progressive sperm motility, total sperm motility, and normal sperm morphology of OP pesticides-exposed subjects compared to the unexposed subjects. However, after subtype and sensitivity analyses, exposure to OP pesticides did not reduce sperm count. Also, after sensitivity analysis, OP pesticides exposure did not alter progressive sperm motility.ConclusionThis study demonstrates that OP pesticides exposure reduced sperm count, concentration, total and progressive motility, and normal sperm morphology, possibly via a testosterone-independent mechanism.

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Section: Discussionmentioning

confidence: 99%

“…An estimate of about one in six (approximately, 15%) couples are affected by infertility globally, and about 50% of this is due to male factor only and in combination with female factor (1)(2)(3). This has been associated with the global decline in sperm quality (4,5), which occurs in concert with hormonal disruption (4).…”

Section: Introductionmentioning

confidence: 99%

Impact of organophosphate pesticides exposure on human semen parameters and testosterone: a systematic review and meta-analysis

Hamed,

Akhigbe,

Adeogun

et al. 2023

Front. Endocrinol.

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“…Semen samples were collected through masturbation into a clean and sterile wide-mouthed plastic universal sample bottle at our hospital with 2–7-days intervals of sexual abstinence ( 18 ). Semen analyses were performed pretreatment and 3 months after medication based partly on the World Health Organization 2010 report, using the Sperm Motility Analyzing System (SMAS™: DITECT Corp., Tokyo, Japan) after 30 min of liquefaction at room temperature ( 19 ).…”

Section: Methodsmentioning

confidence: 99%

Add-on effects of oral tocopherol supplementation to surgical varicocelectomy on the outcome of assisted reproductive technology: a single-center pilot study report

Takeshima,

Mihara,

Tomita

et al. 2024

Front. Reprod. Health

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IntroductionVaricocelectomy is well known to improve the pregnancy outcome of patients with clinical varicoceles in assisted reproductive technologies as well as spontaneous conception. Therefore, this study aimed to evaluate the additional effects of oral antioxidant therapy after varicocelectomy on the pregnancy outcome in the assisted reproductive technology setting.MethodsThis study was a retrospective cohort study. The subjects were couples among whom the male partner had undergone varicocelectomy and was scheduled for subsequent assisted reproductive technology. Pregnancy outcomes were followed retrospectively in 62 couples with male partners who received tocopherol (antioxidant group) and 37 couples who did not (control group). The tocopherol and control groups were assigned dependent on the decision of the physician in charge and the patient's request. The clinical pregnancy rates per couple and embryo transfer, time to pregnancy, and the number of cycles during transfer to pregnancy were evaluated.ResultsNo significant differences were observed in the pregnancy rate per couple (antioxidant group 70.9% vs. control group 64.9%, P = 0.55) and per embryo transfer (50.4% vs. 39.6%, P = 0.22). Regarding the time to event analyzed by adjusted restricted mean survival time, the mean time to pregnancy was significantly shorter in the antioxidant (tocopherol) group (14.2 vs. 17.4 months, P = 0.025). No significant difference was observed in the embryo transfer cycle to pregnancy (mean embryo transfer cycles: 2.6 vs. 3.0, P = 0.238).ConclusionsAdditional oral tocopherol nicotinate as antioxidant therapy after varicocelectomy was shown to shorten the time to pregnancy. It is recommended that add-on effects be tested in more well-designed randomized controlled trials to examine whether it improves assisted reproductive outcomes.

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“…Several factors such as age [3]- [8] and ejaculatory abstinence period [9] [10] [11] can influence semen quality and/or reproductive hormones.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Age and Ejaculatory Abstinence on Semen Quality and Reproductive Hormones in Africa and the Middle East

Moungala,

Makoyo

2024

ARSci

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Influence of ejaculatory abstinence period on semen quality of 5165 normozoospermic and oligozoospermic Nigerian men: A retrospective study

Cited by 8 publications

References 35 publications

Impact of organophosphate pesticides exposure on human semen parameters and testosterone: a systematic review and meta-analysis

Impact of organophosphate pesticides exposure on human semen parameters and testosterone: a systematic review and meta-analysis

Add-on effects of oral tocopherol supplementation to surgical varicocelectomy on the outcome of assisted reproductive technology: a single-center pilot study report

The Effects of Age and Ejaculatory Abstinence on Semen Quality and Reproductive Hormones in Africa and the Middle East

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