Influence of Electric Foot Shock on Pharmacokinetics of Isosorbide Dinitrate Subcutaneously Administered to Rats

GOMITA, Yutaka; FURUNO, Katsushi; Araki, Yasunori

doi:10.1016/s0021-5198(19)40147-9

Cited by 1 publication

(1 citation statement)

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“…19,20 The electric foot shock model has been employed for inducing acute stress of variable degrees in rodents including mice. 21 The MWM test employed in the present study is one of the most widely accepted models to evaluate learning and memory of animals, particularly spatial memory. 18 The significant decrease in ELT from day 1 to day 4 in mice subjected to mild stress during the acquisition trials denotes an enhancement in acquisition of learning.…”

Section: Discussionmentioning

confidence: 99%

Investigations into mild electric foot shock stress-induced cognitive enhancement: possible role of angiotensin neuropeptides

Bali

Singh

Jaggi

2012

J Renin Angiotensin Aldosterone Syst

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This study was designed to investigate the role of angiotensin neuropeptides in mild electric foot shock stress-induced cognitive enhancement in mice. Mild stress was induced by applying mild electric foot shocks of 0.15 mA intensity for 0.5 s. The stress-induced alteration in cognition was assessed using a Morris water maze test. The animals were subjected to mild electric foot shocks 5 min before we recorded escape latency time (ELT), an index of learning, during the first 4 days of a 5-day trial in the Morris water maze. The time spent in target quadrant (TSTQ), an index of retrieval, was noted on the fifth day without prior administration of electric foot shock. The angiotensin-converting enzyme inhibitor lisinopril (5, 10 and 20 mg/kg), and telmisartan (1, 2 and 5 mg/kg), an angiotensin II receptor blocker, were employed to assess the role of angiotensin neuropeptides. The application of mild electric shocks significantly decreased ELT and increased TSTQ, indicating enhancement in stress-induced learning and memory. However, administration of lisinopril and telmisartan significantly attenuated the stress-induced decrease in ELT and increase in TSTQ. It may be concluded that mild electric foot shock-induced stress triggers the release of angiotensin neuropeptides that may be responsible for memory enhancement.

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