Friedel-Crafts polyetherketones were prepared from o-chlorophenol, 1,4-phenylenedioxy diacetylchloride (1,4-PDC), chloroacetyl chloride (CAC), 1,2-dichloroethane (DCE), and dichloromethane (DCM) using anhydrous aluminium chloride (AlCl 3 ) as catalyst and carbon disulfide (CS 2 ) as solvent. These resins were characterized by IR spectroscopy and gel permeation chromatography. Carius method was employed to obtain the percentage of chlorine content in the resins. The kinetic parameters for the thermal behavior of the resins were evaluated from thermogravimetry (TG) using Broido method. Differential scanning calorimetry (DSC) thermograms of these resins were also obtained. All the polyetherketones were tested for their antimicrobial properties against bacteria, fungi, and yeast. It was observed that most of the polyetherketones synthesized could be used as antibacterial and antifungal agents.