Excessive fruit drop (i.e., June drop) can limit orchard profitability of certain pecan [Carya illinoinensis (Wangenh.) K. Koch] cultivars. The present study examines efficacy of aminoethoxyvinylglycine (AVG; formulated as ReTain®; Valent BioSciences, Libertyville, IL), a natural ethylene inhibitor, for increasing nutmeat yield in a commercial ‘Desirable’ pecan orchard over a 2-year period. The 30-ha experiment consisted of two treatments (nontreated versus ReTain) in the first year, an “off” year in the orchard's alternate bearing cycle. The second year's study, an “on” year, consisted of four treatments (i.e., “08 nontreated + 09 nontreated,” “08ReTain + 09 nontreated,” “08 nontreated + 09 ReTain,” and “08ReTain + 09 ReTain”). AVG, as ReTain [132 mg·L−1 a.i. (11.7 oz/acre)], was applied as two post-pollination canopy sprays (937 L·ha−1) 2 weeks apart in both years. During the “off” year, ReTain increased nut yield parameters with ReTain increasing kernel yield by 36% (704 kg·ha−1 versus 516 kg·ha−1) over that of nontreated trees. In the subsequent “on” crop year, the trees exhibiting a ReTain-associated previous year yield increase of ≈36% exhibited a reduction in yield of ≈25%, thus largely negating the previous season's yield increase over a 2-year alternate bearing cycle. Additionally, ReTain-treated trees during the “on” year failed to exhibit an increase in yield parameters over that of the nontreated control. As a result of a lag effect on subsequent year yield parameters, ReTain offers potential as a crop-load management tool for ‘Desirable’ orchards in “off” years such as a year of relatively high nutmeat price followed by a year of relatively low price. There appears to be no positive effect on yield when used in a heavy crop-load “on” year of an alternate bearing cycle. Thus, ReTain might have benefit for stabilizing alternate bearing in ‘Desirable’ pecan orchards. Kernel quality (defined as percentage of nut weight as kernel) of individual nuts from “on” year trees was not as sensitive to units of yield increase as for individual nuts of “off” year trees, thus implying that the rate of assimilate partitioning to individual reproductive structures in “off”-year trees is not as great as that in “on”-year trees.