Influence of endothelial nitric oxide synthase polymorphisms in psoriasis risk

Abstract

Abstract:Nitric oxide (NO) is a potent regulator of keratinocyte growth and differentiation that has been implicated in the pathogenesis of psoriasis (Ps). The NOS3 -786 T/C (SNP id rs2070744; www.ensembl.org ), intron 4 variable number tandem repeat (VNTR), and Glu298Asp (SNP id rs1799983) polymorphisms, have been associated with differences in NO plasma concentrations and with the risk of hypertension (HT) and ischemic cardiac disease (IC). The aim of this study was to determine whether the above mentioned NOS3 variants contributed to the risk of Ps, and were associated with the risk for HT and CAD in these patients. A total of 368 patients with chronic plaque Ps and 400 healthy controls were genotyped for the NOS3 -786 T/C, intron 4 VNTR, and Glu298Asp polymorphisms. Carriers of the -786 C allele were significantly more frequent among the patients (p<0.001). Carriers of the 4-repeats allele (45+44 genotypes) were also more frequent a (p<0.001). No significant difference was found for the Glu298Asp polymorphism. None of the NOS3 variants was associated with Ht and CAD in our population. In conclusion, NOS3 gene polymorphism would be risk factors for developing Ps.

Long-term Western diet intake leads to dysregulated bile acid signaling and dermatitis with Th2 and Th17 pathway features in mice

“…Our data suggest that WD specifically activated TGR5 signaling in dermatitic lesions. Activated TGR5 in the dermatitis mice increased Nos3 expression, which likely leads to increased production of nitric oxide, a potent regulator for the growth and differentiation of keratinocytes and is implicated in the pathogenesis of and risk for developing psoriasis [42,43]. TGR5 activation in dermatitic lesions was also demonstrated by the induction of Trpa1 and Trpv1, which are the downstream mediators of many pruritogenic pathways.…”

Psoriasis and hypertension: a case‐control study

“…Endothelin-1 levels were correlated with psoriasis activity, and oxidative stress may play a role by destructive effects of reactive oxygen species, damaging endothelium-dependent vasodilatation. 7,16,17 OR, odds ratio. The main factors associated with psoriasis and hypertension in men are diabetes and obesity, whereas in women they are smoking and obesity (Table 2).…”

The Immunogenetics of Psoriasis and Implications for Drug Repositioning

“…As mentioned earlier, recent studies have also found interleukin 1β ( IL-1β ), tumor necrosis factor ( TNF ) [ 47 ], vitamin D receptor ( VDR ) [ 48 ], nitric oxide synthase 3 ( NOS3 ) [ 49 ], and other genes to be overexpressed in psoriasis patients (GOF). Therefore, we used inhibitors for these targets and in turn designed drug repositioning strategies for psoriasis.…”