Influence of environmental and nutritional factors on salivary gland tumorigenesis with a special reference to dietary lipids

Actis, A. B.; Eynard, A.R.

doi:10.1038/sj.ejcn.1601077

Cited by 20 publications

(9 citation statements)

References 34 publications

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“…The factors reported to be associated with cancer of salivary glands are prior childhood radiation of head and neck (Katz and Preston-Martin 1984), wood dust (Klitenberg et al, 1984), silica (Zheng et al, 1996), nitrosamines in rubber workers (Straif et al, 1999) and smoking (implicated in case of Warthin's tumour (Pinkston and Cole 1996)). Dietary analysis revealed a possible protective effect for a diet high in polyunsaturated fatty acids (Actis and Eynard 2000). Women with increased risk for salivary gland cancer have shown to reveal a history of early menarche and nulliparity, possibly depicting a hormonal effect (Horn-Ross et al, 1999).…”

Section: Cancer Nose and Paranasal Sinusmentioning

confidence: 99%

Head and Neck Cancer: Global Burden and Regional Trends in India

Mishra

Meherotra²

2014

Asian Pacific Journal of Cancer Prevention

158

100

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Section: Cancer Nose and Paranasal Sinusmentioning

confidence: 99%

Head and Neck Cancer: Global Burden and Regional Trends in India

Mishra

Meherotra²

2014

Asian Pacific Journal of Cancer Prevention

158

100

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“…In particular, n-3 fatty acids comparatively diminished the hyperproliferative effect linked to DMBA administration. The beneficial effects of n-3 rich food should be emphasized in the prevention of oral neoplastic lesions, as previously proposed [1,2]. …”

Section: Discussionmentioning

confidence: 94%

Untitled

et al. 2002

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BackgroundThe lack of certain essential polyunsaturated fatty acids (PUFAs) induces perturbation in cell proliferation, apoptosis and dedifferentiation that could be linked to an increased protumorigenic trend. Contrarily, n-3 essential fatty acids (EFAs) arrest cell proliferation in several tumor models. According to the concept of field cancerization, multiple patches of abnormal epithelial proliferation may coexist in the vicinity of oropharyngeal neoplasms.The purpose of the present study is to determine whether certain dietary PUFAs differentially modulate the patterns of cell proliferation and apoptosis at non-tumoral sites of the oral mucosa in mice bearing DMBA induced salivary tumors.After weaning, BALB/c mice were assigned to four diets: Control (C), Corn Oil (CO), Fish (FO) and Olein (O). Two weeks later, DMBA was injected into the submandibular area. The animals were sacrificed between 94 and 184 days at 4–6 PM. Fixed samples of lip, tongue and palate were stained using H-E and a silver technique. A quantification of AgNORs in the basal (BS) and suprabasal stratum (SBS) of the covering squamous epithelia as well as of mitosis and apoptosis was performed.ResultsAnalysis of Variance showed greater proliferation in tongue than in palate or lip. According to the diet, a significant difference was found in the Fish Oil, in which palate exhibited fewer AgNOR particles than that of the control group, both for BS and SBS (p < 0.05 and 0.152, respectively), indicating a reduced cell proliferation.ConclusionsThese results corroborate and reaffirm that the patterns of cell proliferation, apoptosis and differentiation of the oral stratified squamous epithelium may be differentially modulated by dietary lipids, and arrested by n-3 fatty acids, as shown in several other cell populations.

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“…Study results suggest that increased consumption of fruits and vegetables and lower cholesterol are associated with lower salivary gland cancer risk [11]. Further research is needed to assess the role of nutritional factors in salivary gland tumorigenesis [15]. Tumor 2 cm or less in greatest dimension without extraparenchymal extension * T2…”

Section: Treatmentmentioning

confidence: 98%

Salivary gland neoplasms

Day

Deveikis²,

Gillespie³

et al. 2004

Curr. Treat. Options in Oncol.

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Treatment and cure of salivary gland neoplasms requires surgical intervention in most cases. For parotid neoplasms, the most common surgical procedure performed is the superficial parotidectomy with facial nerve preservation. Postoperative radiation therapy is indicated in high-grade salivary gland malignancies and malignancies with increased risk of locoregional recurrence. Primary radiation, including neutron beam techniques, may play a role in certain histologic types or nonoperative candidates. Chemotherapy has yet to result in improvements in survival or quality of life in the treatment of salivary gland malignancy. Advances in radiation therapy techniques, including intensity-modulated radiation therapy, provide opportunities for reduced morbidity.

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Influence of environmental and nutritional factors on salivary gland tumorigenesis with a special reference to dietary lipids

Cited by 20 publications

References 34 publications

Head and Neck Cancer: Global Burden and Regional Trends in India

Head and Neck Cancer: Global Burden and Regional Trends in India

Untitled

Salivary gland neoplasms

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