Influence of Environmental Factors on Porphyrin Metabolism

Metabolism and biochemical toxicity of PCBs and PBBs

“…Sinclair and Granick (30) showed that cultured liver cells respond rapidly to PCBs in accumulation of uroporphyrin. Simon et al (31) suggested that porphyria may be due to the destruction of the phospholipid structure of cell membrane, resulting in increased permeability of the substrate. Hirayama et al (32), observed hypobilirubinemia in Yusho patients and suggested that the induction of bilirubin UDP-glucuronyltransferase may be responsible for the low plasma bilirubin content.…”