Addressing the challenges of data scarcity and privacy, synthetic data generation offers an innovative solution that advances manufacturing assembly operations and data analytics. Serving as a viable alternative, it enables manufacturers to leverage a broader and more diverse range of machine learning models by incorporating the creation of artificial data points for training and evaluation. Current methods lack generalizable framework for researchers to follow and solve these issues. The development of synthetic data sets, however, can make up for missing samples and enable researchers to understand existing issues within the manufacturing process and create data-driven tools for reducing manufacturing costs. This paper systematically reviews both discrete and continuous manufacturing process data types with their applicable synthetic generation techniques. The proposed framework entails four main stages: Data collection, pre-processing, synthetic data generation, and evaluation. To validate the framework’s efficacy, a case study leveraging synthetic data enabled an exploration of complex defect classification challenges in the packaging process. The results show enhanced prediction accuracy and provide a detailed comparative analysis of various synthetic data strategies. This paper concludes by highlighting our framework’s transformative potential for researchers, educators, and practitioners and provides scalable guidance to solve the data challenges in the current manufacturing sector.