Influence of epidermal growth factor on growth of bovine mammary tissue in athymic nude mice

ERBB Receptors and Their Ligands in the Developing Mammary Glands of Different Species: Fifteen Characters in Search of an Author

“…The positive effect of EGF on ruminant mammary epithelium was confirmed by transplantation of mammary tissue from mid-pregnant heifers into ovariectomized-sialoadenectomized athymic mice. In this model, EGF had almost no effect on epithelial proliferation, whereas it synergized with the combination of E and P to restore the level of DNA synthesis back to that in ovary-intact, steroid-treated mice [ 146 ]. These findings raise the prospect that additional interactions between ligand-stimulated proliferation and ovarian hormones, as well as perhaps the nature of the stroma, create a stage- and tissue-specific growth-modulating environment for the mammary epithelium.…”

“…Furthermore, several ERBB1-ligands are essential during this developmental stage when deletion of Areg leads to impaired lobuloalveolar development, which is exacerbated by the additional deletion of Egf and Tgfa [ 40 ]. More specifically, TGFα was more effective than EGF for inducing lobuloalveolar growth [ 146 , 147 ]. Unlike ERBB1 and ERBB2, an indispensable role exists for ERBB3 during gestation, as evidenced by the fact that Erbb3 -null mice have defective lobuloalveolar expansion, decreased epithelial proliferation and enhanced apoptosis of luminal epithelial cells, together with impaired activation of AKT and STAT5.…”

Impact of lean growth genotype, dietary amino acid regimen and level of chronic immune system activation on sow lactational performance

“…Epidermal growth factor (EGF) has been shown to induce manunary tissue growth in vitro (Tonelli and Soroff, 1980;Taketani and Oka, 1983) and local administration of EGF via intramanmiary implant has been reported to increase lobular/alveolar development in both mature (Vonderhaar, 1987) and immature mouse mammary glands (Coleman et al, 1988). It was suggested by Sheffield and Yuh (1988b) that EGF may act synergistically with estrogen and progesterone. Transforming growth factors (TGF-a and TGF-61) are structuraily similar to EGF and may possess similar function (Plaut, 1993).…”