Influence of epileptic activity during sleep on cognitive performance in benign childhood epilepsy with centrotemporal spikes

Nissenkorn, Andreea; Pappo, A; Feldmann, Yael; Heimer, Gali; Bar‐Yosef, Omer; Tzadok, Michal; Polack, Orli; Bord, Ayelet; Levav, Miriam; Ben‐Zeev, Bruria

doi:10.1016/j.ejpn.2017.07.001

Cited by 19 publications

(9 citation statements)

References 22 publications

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“…These results are similar to those recently reported in a similarly sized retrospective study. 20 The absence of general intelligence impairments and the presence of normal memory, including verbal memory, match the majority tendency of the literature regarding cognition and BECTS. 4 The same holds true for mild behavioral problems, as reported by the CBCL.…”

Section: Discussionsupporting

confidence: 56%

Benign epilepsy with centrotemporal spikes: Correlating spike frequency and neuropsychology

et al. 2018

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Section: Discussionsupporting

confidence: 56%

Benign epilepsy with centrotemporal spikes: Correlating spike frequency and neuropsychology

et al. 2018

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“…Previous studies ( 10 , 44 ) suggest that children with SeLECTS (SWI ≥ 50%) have an earlier age of onset, longer disease duration, and more seizures than children with SeLECTS (SWI < 50%). However, we found no such patterns in our sample.…”

Section: Discussionmentioning

confidence: 91%

“…This is tentatively consistent with our hypothesis that frequent discharges during sleep would alter normal brain magnetic source activity and thus affect cognitive function. To the best of our knowledge, this is the first MEG study of unmedicated SeLECTS (SWI < 50%), unmedicated SeLECTS (SWI ≥ 50%), and HC subjects, as previous studies have mainly used fMRI and focused on relevant functional networks of the brain ( 42 – 44 ).…”

Section: Discussionmentioning

confidence: 99%

Relationship between brain activity, cognitive function, and sleep spiking activation in new-onset self-limited epilepsy with centrotemporal spikes

Sun

et al. 2022

Front. Neurol.

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ObjectiveThis study aimed to investigate the relationship between cognitive function sleep spiking activation and brain activity in self-limited epilepsy with centrotemporal spikes (SeLECTS).MethodsWe used spike-wave index (SWI), which means the percentage of the spike and slow wave duration to the total non-REM (NREM) sleep time, as the grouping standard. A total of 14 children with SeLECTS (SWI ≥ 50%), 21 children with SeLECTS (SWI < 50%), and 20 healthy control children were recruited for this study. Cognitive function was evaluated using the Wechsler Intelligence Scale for Children, Fourth Edition (Chinese version) (WISC-IV). Magnetic source activity was assessed using magnetoencephalography calculated for each frequency band using the accumulated source imaging (ASI) technique.ResultsChildren with SeLECTS (SWI ≥ 50%) had the lowest cognitive function scores, followed by those with SeLECTS (SWI < 50%) and then healthy controls. There were significant differences in the localization of magnetic source activity between the three groups: in the alpha (8–12 Hz) frequency band, children with SeLECTS (SWI ≥ 50%) showed deactivation of the medial frontal cortex (MFC) region; in the beta (12–30 Hz) frequency band, children with SeLECTS (SWI ≥ 50%) showed deactivation of the posterior cingulate cortex (PCC) segment; and in the gamma (30–80 Hz) frequency band, children in the healthy group showed activation of the PCC region.ConclusionThis study revealed significant decreases in cognitive function in children with SeLECTS (SWI ≥ 50%) compared to children with SeLECTS (SWI < 50%) and healthy children, as well as significant differences in magnetic source activity between the three groups. The findings suggest that deactivation of magnetic source activity in the PCC and MFC regions is the main cause of cognitive function decline in SeLECTS patients with some frequency dependence.

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“…The resulted continuous regressor expresses the frequency (i.e., density) of ED for time window along the entire fMRI session at singlesubject level. The rationale behind this approach is not trivial as abundance of ED is recognized as a prognostic factor of the neurocognitive outcome in CECTS (16,31) and often influences the clinicians' decision tree including treatment (32,33). Second, our analyses provide a significant contribution within the "puzzle" of evidences that try to explain the complex relationship between epilepsy and cognition in CECTS.…”

Section: Discussionmentioning

confidence: 99%

Mapping the Effect of Interictal Epileptic Activity Density During Wakefulness on Brain Functioning in Focal Childhood Epilepsies With Centrotemporal Spikes

et al. 2019

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Childhood epilepsy with centrotemporal spikes (CECTS) is the most common type of "self-limited focal epilepsies." In its typical presentation, CECTS is a condition reflecting non-lesional cortical hyperexcitability of rolandic regions. The benign evolution of this disorder is challenged by the frequent observation of associated neuropsychological deficits and behavioral impairment. The abundance (or frequency) of interictal centrotemporal spikes (CTS) in CECTS is considered a risk factor for deficits in cognition. Herein, we captured the hemodynamic changes triggered by the CTS density measure (i.e., the number of CTS for time bin) obtained in a cohort of CECTS, studied by means of video electroencephalophy/functional MRI during quite wakefulness. We aim to demonstrate a direct influence of the diurnal CTS frequency on epileptogenic and cognitive networks of children with CECTS. A total number of 8,950 CTS (range between 27 and 801) were recorded in 23 CECTS (21 male), with a mean number of 255 CTS/patient and a mean density of CTS/30 s equal to 10,866 ± 11.46. Two independent general linear model models were created for each patient based on the effect of interest: "individual CTS" in model 1 and "CTS density" in model 2. Hemodynamic correlates of CTS density revealed the involvement of a widespread cortical-subcortical network encompassing the sensory-motor cortex, the Broca's area, the premotor cortex, the thalamus, the putamen, and red nucleus, while in the CTS event-related model, changes were limited to blood-oxygen-level-dependent (BOLD) signal increases in the sensory-motor cortices. A linear relationship was observed between the CTS density Vaudano et al. Hemodynamic Effects of CTS Density hemodynamic changes and both disease duration (positive correlation) and age (negative correlation) within the language network and the bilateral insular cortices. Our results strongly support the critical role of the CTS frequency, even during wakefulness, to interfere with the normal functioning of language brain networks.

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Influence of epileptic activity during sleep on cognitive performance in benign childhood epilepsy with centrotemporal spikes

Cited by 19 publications

References 22 publications

Benign epilepsy with centrotemporal spikes: Correlating spike frequency and neuropsychology

Benign epilepsy with centrotemporal spikes: Correlating spike frequency and neuropsychology

Relationship between brain activity, cognitive function, and sleep spiking activation in new-onset self-limited epilepsy with centrotemporal spikes

Mapping the Effect of Interictal Epileptic Activity Density During Wakefulness on Brain Functioning in Focal Childhood Epilepsies With Centrotemporal Spikes

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