Influence of ethanol on gastric absorption and metabolism of albendazole and mebendazole

Justel, Antonio León; Alvarez, Ana I.; Alonso, M.L.; Estal, J.L. del; Villaverde, C.; Barrio, J.P.; Prieto, Josefa González

doi:10.1016/0376-8716(94)90009-4

Cited by 5 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Review by Dayan gave valuable information on nonclinical toxicity of 2 and 218 . Influence of ethanol on gastric absorption and metabolism of albendazole 2 and mebendazole 218 was investigated . It was reported that the administration of ethanol did not affect the kinetic mechanism of the absorption process but the absorption rate decreased in all treatments except in 5% acute ethanol .…”

Section: Pharmacokinetics/pharmacodynamics Of Benzimdazolementioning

confidence: 86%

“…Influence of ethanol on gastric absorption and metabolism of albendazole 2 and mebendazole 218 was investigated . It was reported that the administration of ethanol did not affect the kinetic mechanism of the absorption process but the absorption rate decreased in all treatments except in 5% acute ethanol . Dose‐depended apoptosis induced by B‐norcholesteryl benzimidazole 221 was reported .…”

Section: Pharmacokinetics/pharmacodynamics Of Benzimdazolementioning

confidence: 93%

See 1 more Smart Citation

Functionalized Benzimidazole Scaffolds: Privileged Heterocycle for Drug Design in Therapeutic Medicine

Ajani

Aderohunmu

Ikpo

et al. 2016

Archiv der Pharmazie

View full text Add to dashboard Cite

Benzimidazole derivatives are crucial structural scaffolds found in diverse libraries of biologically active compounds which are therapeutically useful agents in drug discovery and medicinal research. They are structural isosteres of naturally occurring nucleotides, which allows them to interact with the biopolymers of living systems. Hence, there is a need to couple the latest information with the earlier documentations to understand the current status of the benzimidazole nucleus in medicinal chemistry research. This present work unveils the benzimidazole core as a multifunctional nucleus that serves as a resourceful tool of information for synthetic modifications of old existing candidates in order to tackle drug resistance bottlenecks in therapeutic medicine. This manuscript deals with the recent advances in the synthesis of benzimidazole derivatives, the widespread biological activities as well as pharmacokinetic reports. These present them as a toolbox for fighting infectious diseases and also make them excellent candidates for future drug design.

show abstract

Section: Pharmacokinetics/pharmacodynamics Of Benzimdazolementioning

confidence: 86%

Section: Pharmacokinetics/pharmacodynamics Of Benzimdazolementioning

confidence: 93%