Influence of excitation pulse duration of dielectric barrier discharges on biomedical applications

Hirschberg, J.H.K.K.; Omairi, Tarek; Mertens, Nina; Helmke, Andreas; Emmert, Steffen; Viöl, Wolfgang

doi:10.1088/0022-3727/46/16/165201

Cited by 25 publications

(16 citation statements)

References 31 publications

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“…Both rotational and electron temperature were ascertained higher for the CP 100. The presence of lower rotational and electron temperatures, respectively, for ns plasma sources is also depicted in refs . The effect of lower gas temperature is described in reduced gas heating due to short pulses and strong excitation of the gas because of high energy electrons alternatively.…”

Section: Resultsmentioning

confidence: 93%

Inactivation of Microorganisms Using Cold Atmospheric Pressure Plasma with Different Temporal Discharge Characteristics

Mertens¹,

Mahmoodzada²,

Helmke

et al. 2014

Plasma Process. Polym.

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The effect of CAP on the dermatologic relevant bacteria E. coli, P. aeruginosa and the yeast C. albicans is studied in vitro. Two dielectric barrier discharge plasma devices with different temporal pulse characteristics are compared concerning their efficacy of germ inactivation. The study includes analyses of temperature, ozone concentration and UV radiation in the discharge gap as well as the influence on the growth medium in terms of temperature, pH value, NnormalO2−, NnormalO3−, and H2O2. The investigations are concluded by tests of growth inhibition, the morphological structure, and DNA damages of the microorganisms. The results demonstrate, that both devices are able to inactivate the germs, although the nanosecond pulsed plasma source has a higher efficacy based on a higher chemical discharge productivity.

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Section: Resultsmentioning

confidence: 93%

Inactivation of Microorganisms Using Cold Atmospheric Pressure Plasma with Different Temporal Discharge Characteristics

Mertens¹,

Mahmoodzada²,

Helmke

et al. 2014

Plasma Process. Polym.

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“…The overvoltage that produces SOPs also contributes to more diffuse and extended filaments in DBDs. The correlation between diffusive-appearing DBDs and the rate of voltage rise has recently been noted by Hirschberg et al [20], Yang et al [21] and Liu et al [22]. For example, Liu et al [22] quantified the transition from a filamentary to a diffuse mode in DBDs sustained in air when applying a larger overvoltage.…”

Section: Sops Produced By a Single Plasma Filamentmentioning

confidence: 84%

Self-organization of single filaments and diffusive plasmas during a single pulse in dielectric-barrier discharges

Babaeva

Kushner

2014

Plasma Sources Sci. Technol.

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Self-organization of filaments in dielectric-barrier discharges (DBDs) probably has many origins. However, the dominant cause is proposed to be the accumulation of charge on the surfaces of the bounding dielectrics that reinforces successive discharge pulses to occur at the same locations. A secondary cause is the electrostatic repulsion of individual plasma filaments. Self-organization typically develops over many discharge pulses. In this paper, we discuss the results of a computational investigation of plasma filaments in overvoltage DBDs that, under select conditions, display self-organized patterns (SOPs) of plasma density during a single discharge pulse. (Overvoltage refers to the rapid application of a voltage in excess of the quasi-dc breakdown voltage.) The origin of the SOPs is a synergistic relationship between the speed of the surface-ionization waves that propagate along each dielectric and the rate at which avalanche occurs across the gap. For our test conditions, SOPs were not observed at lower voltages and gradually formed at higher voltages. The same conditions that result in SOPs, i.e. the application of an overvoltage, also produce more diffuse discharges. A transition from a single narrow filament to a more diffuse structure was observed as overvoltage was approached. The sensitivity of SOPs to the orientation and permittivity of the bounding dielectrics is discussed.

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“…Therefore, a high‐resolution Echelle spectrometer (Aryelle‐Butterfly 400; LTB Lasertechnik Berlin GmbH, Berlin, Germany) was used, which allows a resolution of <80 pm. A more detailed description of the optical setup can be found in . To avoid a wavelength shift, the setup was first calibrated with a mercury vapor lamp (DH 2000; Ocean Optics, Inc., Dunedin, USA).…”

Section: Methodsmentioning

confidence: 99%

A μs‐Pulsed Dielectric Barrier Discharge Source: Physical Characterization and Biological Effects on Human Skin Fibroblasts

Tiede

Hirschberg

Viöl

et al. 2016

Plasma Processes & Polymers

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As the field of plasma medicine eventually develops, safety aspects of biocompatible plasma sources are becoming ever more important for a safe usage of plasma devices as medical instruments. In this study physical and biological safety parameters of an atmospheric pressure dielectric barrier discharge (DBD) source with a phosphate buffered saline-electrode (PBS-electrode) were analyzed. For a general characterization of this DBD device the dissipated power, rotational and electron energies, and reactive species were investigated. Cell vitality tests of human skin fibroblasts treated with the device directly and indirectly were performed using an MTS assay. Additionally, applying a host cell reactivation (HCR) assay fibroblasts' DNA repair capacity for plasma-induced damages was examined. Our risk assessments indicate that this DBD device can be used safely in therapeutic applications.A ms-pulsed dielectric barrier discharge source . . . Plasma Process. Polym. 2016, 13, 775-787 ß

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Influence of excitation pulse duration of dielectric barrier discharges on biomedical applications

Cited by 25 publications

References 31 publications

Inactivation of Microorganisms Using Cold Atmospheric Pressure Plasma with Different Temporal Discharge Characteristics

Inactivation of Microorganisms Using Cold Atmospheric Pressure Plasma with Different Temporal Discharge Characteristics

Self-organization of single filaments and diffusive plasmas during a single pulse in dielectric-barrier discharges

A μs‐Pulsed Dielectric Barrier Discharge Source: Physical Characterization and Biological Effects on Human Skin Fibroblasts

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