Influence of exercise amount and intensity on long-term weight loss maintenance and skeletal muscle mitochondrial ROS production in humans

Larsen, Steen; Dandanell, Sune; Kristensen, Kasper Birch; Jørgensen, Sofie Drevsholt; Dela, Flemming; Helge, Jørn Wulff

doi:10.1139/apnm-2018-0577

Cited by 5 publications

(5 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our meta-analysis showed that LVEF was significantly improved in patients with VHD after the exercise intervention, which would have an integral role in improving their clinical prognosis after surgery. In addition, the improved prognosis of patients with VHD after surgery due to increased LVEF may be associated with enhanced body metabolism from increased stroke volume and oxygen content [ 67 ].…”

Section: Discussionmentioning

confidence: 99%

“…Incorporating strategies such as early mobilisation and respiratory-based exercises may provide some benefits in preventing postoperative pulmonary complications [ 71 ]. Our meta-analysis showed that exercise improved cardiopulmonary function and quality of life in patients with VHD, which may be related to the fact that moderate exercise may reduce CVD risk by increasing myocardial blood flow reserve, improving vascular endothelial cell function, improving skeletal muscle oxygen uptake and utilisation, and reducing mitochondrial damage in cardiomyocytes, thereby promoting body metabolism [ 67 , 72 ]. In addition, a study indicated that exercise after TAVI improved functional capacity, even exceeding the effects of the TAVI surgery [ 73 ], consistent with our results.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Exercise as the Key to Improve Cardiopulmonary Function in Patients with Valvular Heart Disease: A Systematic Review and Meta-Analysis

Zeng,

Pi,

Zhang

et al. 2023

Rev. Cardiovasc. Med.

View full text Add to dashboard Cite

Background: Valvular heart disease (VHD) is a type of cardiovascular disease with abnormal heart valve structure and/or function and a rapidly growing cause of global cardiovascular morbidity and mortality. Physical inactivity is a problem for patients with VHD, especially after surgery. However, there is no data on the effects of exercise on VHD from large multicentre randomised controlled trials (RCTs). Therefore, we conducted a systematic review and meta-analysis to provide a comprehensive analysis of small RCTs to evaluate the effects of exercise on cardiopulmonary function in patients with VHD and provide an evidence-based medicine basis for developing and guiding the clinical application of exercise in patients with VHD. Methods: We conducted a systematic review and meta-analysis of RCTs. We systematically searched electronic databases (PubMed, Web of Science, Embase, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure [CNKI], China Science and Technology Journal Database [VIP], WanFang Database, and SinoMed [CBM]) for all studies on exercise and VHD from their inception to January 2023. The quality of included studies was assessed using the Cochrane risk-of-bias tool. The primary outcomes were the six-minute walk test distance (6MWD), left ventricular ejection fraction (LVEF), and short-form 36-item health survey (SF-36). Results: This systematic review included 22 RCTs with 1520 subjects (869 men and 651 women). The meta-analysis results showed that exercise significantly improved exercise capacity measured by the 6MWD (mean difference [MD] = 25.54, 95% confidence interval [CI] = 19.98–31.11, = 0%, p 0.00001), LVEF (MD = 6.20, 95% CI = 4.76–7.65, = 66%, p 0.00001), and quality of life measured by the SF-36 (physical function: MD = 3.42, 95% CI = 2.12–4.72, = 12%, p 0.00001; mental health: MD = 3.86, 95% CI = 0.52–7.20, = 68%, p = 0.020; social function: MD = 2.30, 95% CI = 0.64–3.97, = 45%, p = 0.007; bodily pain: MD = 2.60, 95% CI = 0.83–4.37, = 22%, p = 0.004) in patients with VHD compared to healthy controls. Conclusions: This study suggests that exercise can significantly improve cardiopulmonary function, enhance physical and social function, reduce bodily pain, and potentially improve mental health in patients with VHD, providing an evidence-based basis for better recovery in patients with VHD.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Exercise as the Key to Improve Cardiopulmonary Function in Patients with Valvular Heart Disease: A Systematic Review and Meta-Analysis

Zeng,

Pi,

Zhang

et al. 2023

Rev. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…Analysis of mitochondrial function was performed in permeabilized skeletal muscle fibers. Mitochondrial respiratory capacity was determined as previously described ( Dohlmann et al, 2018 ) using high-resolution respirometry (Oxygraph-2k, Oroboros Instruments, Innsbruck, Austria), and reactive oxygen species (ROS) production was measured fluorometrically (Xenius XC, SAFAS, Monaco) as previously described ( Larsen et al, 2019 ) using the amplex red probe. See Supplementary Material for the detailed protocols.…”

Section: Methodsmentioning

confidence: 99%

Metabolic effects of alternate-day fasting in males with obesity with or without type 2 diabetes

et al. 2022

Self Cite

View full text Add to dashboard Cite

Alternate-day fasting induces oscillations in energy stores. We hypothesized that repeated oscillations increases insulin secretion and sensitivity, and improve metabolic health in patients with obesity with or without type 2 diabetes (T2DM). Twenty-three male patients fasted every other day for 30 h for 6 weeks. Experiments included resting energy expenditure, continuous glucose monitoring, intravenous glucose tolerance test, euglycemic hyperinsulinemic clamp, body composition, hepatic triglyceride content, muscle biopsies which were performed at baseline, during 3 weeks without allowed weight loss, and after additional 3 weeks with weight loss. Bodyweight decreased ∼1% and further ∼3% during weeks one to three and four to six, respectively (p < 0.05). Only minor changes in fat mass occurred in weeks 1–3. With weight loss, visceral fat content decreased by 13 ± 3% and 12 ± 2% from baseline in patients with and without T2DM, respectively (p < 0.05). Hepatic triglyceride content decreased by 17 ± 9% and 36 ± 9% (with diabetes) and 27 ± 8% and 40 ± 8% (without diabetes) from baseline to week 3 and week 6, respectively (all p < 0.05). Muscle lipid and glycogen content oscillated with the intervention. Glucose homeostasis, insulin secretion and sensitivity was impaired in patients with T2DM and did not change without weight loss, but improved (p < 0.05) when alternate day fasting was combined with weight loss. In conclusion, alternate-day fasting is feasible in patients with obesity and T2DM, and decreases visceral fat and liver fat deposits. Energy store oscillations by alternate-day fasting do not improve insulin secretion or sensitivity per se.Clinical Trial registration: (ClinicalTrials.gov), (ID NCT02420054).

show abstract

“…However, recent reviews have shown the beneficial effects of participation in sports, including competitive sports, on overall PA levels [112]. There is also evidence of a dose-response effect between the number of sports sessions per week and the quantified beneficial health outcomes [113]. Therefore, while some have questioned the direct impact of sports participation on PA levels [114], it seems that playing sports can favor a broad spectrum of development for overall physical fitness, along with motor competence, that has been shown to predict overall PA levels [115].…”

Section: School Sportsmentioning

confidence: 99%

Active Schools in Europe—A Review of Empirical Findings

Bailey

Ríes

Scheuer³

2023

Sustainability

View full text Add to dashboard Cite

Physical activity is an important part of children’s and young people’s healthy functioning, but evidence suggests many students are inactive to the extent that they are compromising their well-being. Traditionally, schools have played a minor role in contributing to physical activity, but it has held relatively low prestige. Some commentators have called for Whole-School or Active School approaches. Physical activity, in these models, is integrated into all aspects of school life. This article reports on a review of the most-cited elements of school-based physical activity promotion, assesses evidence of actual and potential contributions, and provides a tentative weight of evidence judgement for each component. A rapid reviewing methodology was followed, and the searches used a range of specialist academic databases (PsycARTICLES, PsycINFO, SPORTdiscus, CINAHL Complete), Google Scholar, ResearchGate, and Academia.edu, restricted to 2010–2021. Six settings were found to have the potential to add physical activity time, although none suffices alone: Active Breaks; Active Homework; Active Learning; Active Recess; Active Transport; and School Sports. Active Schools offer a plausible solution to the problem of physical inactivity by adding moments of movement and integrating physical activity in all aspects of school life, underlining the need for school-level change, the consideration of stakeholder groups, and the social and physical environments of school.

show abstract

Influence of exercise amount and intensity on long-term weight loss maintenance and skeletal muscle mitochondrial ROS production in humans

Cited by 5 publications

References 38 publications

Exercise as the Key to Improve Cardiopulmonary Function in Patients with Valvular Heart Disease: A Systematic Review and Meta-Analysis

Exercise as the Key to Improve Cardiopulmonary Function in Patients with Valvular Heart Disease: A Systematic Review and Meta-Analysis

Metabolic effects of alternate-day fasting in males with obesity with or without type 2 diabetes

Active Schools in Europe—A Review of Empirical Findings

Contact Info

Product

Resources

About