Influence of Experience Acquired by a Liver Transplantation Center on Extension of Donor Acceptance Criteria

Kurek, Adam; Pawlicki, Jacek; Lekstan, Andrzej; Sekta, Sylwia; Ziaja, Jacek; Cierpka, Lech; Król, Robert

doi:10.1016/j.transproceed.2018.02.154

Transplantation Proceedings

2018

DOI: 10.1016/j.transproceed.2018.02.154

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Influence of Experience Acquired by a Liver Transplantation Center on Extension of Donor Acceptance Criteria

Adam Kurek

Jacek Pawlicki

Andrzej Lekstan

et al.

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2020

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“…Liver transplantation (LT) has achieved great advances because of the development of immunosuppression and surgical techniques. ( 1 ) It is of great importance to accurately assess the viability of a liver graft before implantation into a recipient. In conventional LT, the evaluation of graft viability is based on clinical data, laboratory data, histological data, and organ appearance.…”

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Association of Perfusion Characteristics and Posttransplant Liver Function in Ischemia‐Free Liver Transplantation

et al. 2020

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It has been shown that normothermic machine perfusion (NMP), a novel preservation method, is able to assess and resuscitate liver grafts with risk factors. However, there is no consistent criteria for the assessment of liver grafts with NMP. Ischemia-free liver transplantation (IFLT) includes innovative surgical techniques and NMP, which can protect liver grafts from ischemia throughout organ procurement, preservation, and implantation. In our center, 28 human livers from donation after brain death donors were subjected to IFLT between July 2017 and October 2018. The correlation between posttransplant liver function tests with the perfusion parameters, blood gas analysis of perfusate, and bile biochemistry were analyzed. During the preservation phase, the vascular flow was stable, and the lactate level decreased rapidly. The transaminase release in the perfusate was low but stable, whereas the glucose level remained high. The perfusate lactate and aspartate aminotransferase (AST) levels at 1 hour of perfusion were correlated with the posttransplant peak AST level. There were negative correlations between the portal vein and hepatic artery flows at the end of perfusion and the peak transaminase levels within 7 days after transplantation. In conclusion, during IFLT, NMP is able to bridge the liver grafts from donors to recipients and can allow the assessment of liver function by perfusion characteristics.

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confidence: 99%

Association of Perfusion Characteristics and Posttransplant Liver Function in Ischemia‐Free Liver Transplantation

et al. 2020

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Influence of Experience Acquired by a Liver Transplantation Center on Extension of Donor Acceptance Criteria

Cited by 1 publication

References 17 publications

Association of Perfusion Characteristics and Posttransplant Liver Function in Ischemia‐Free Liver Transplantation

Association of Perfusion Characteristics and Posttransplant Liver Function in Ischemia‐Free Liver Transplantation

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