Introduction This case report is designed to present changes in masticatory muscle activity after surgical correction of mandibular prognathism during maximum voluntary clenching (MVC), mealtimes and sleep in routine daily life.Patient and methods The patient, a Japanese female 18 years and 11 months old, exhibited mandibular prognathism and anterior open bite. Using a portable electromyogram (EMG) recording system masseter and anterior temporal muscle activities were recorded during maximum voluntary clenching (MVC), mealtimes and sleep at home as follows: T0 pre-treatment, T1 6 months after surgery and T2 12 months after surgery.Results Considerable changes in masseter muscle activity during MVC were not found throughout the treatment although masseter muscle activity during mealtimes at T1 and T2 increased to almost double compared to T0 values. Temporal muscle activity during MVC and mealtimes at T1 increased considerably and then the absolute integrated values seemed to decrease slightly. Muscle activities during sleep were very low and indicated almost 0.2% of muscle activity during MVC in both muscles.Conclusion The results of this case show that correction of mandibular prognathism by mandibular setback surgery produces considerable improvement of masticatory muscle activity during mealtimes. Therefore, special attention should be paid to muscle activity during mealtimes, as well as to strong activity during MVC.