To simulate the launching process of missile complex flow, movement, and constraint states, a multifield coupling model is put forward based on a computational fluid dynamics (CFD) method. In this coupled model, a CFD method is used to solve the three-dimensional compressible transient flow, and the six-degree motion of the launching platform is considered, and the virtual contact method is used to deal with the constraint states of the guideway and the slider. The active force and moment are applied to the launching platform to simulate its rolling, pitching, and heaving motions under the 5-level waves. Collision detection is carried out through the minimum clearance distance between the slider and the guideway, and the contact force is handled by a modified Herz collision model. In the problem of launching a missile from the water surface, the change characteristics of the flow field, the load response characteristics, and the relative motion laws of the missile and the launching platform during the catapulting process are investigated. The results show that the motion laws of the projectile and the launch tube in the constrained direction are the same, and the established coupling model is able to simulate the launch separation process of the missile in the constrained state. In addition, the effect of wind load on the missile ejection process is analyzed using the coupled model.