Influence of eye tilt on corneal densitometry

Consejo, Alejandra; Jiménez‐García, Marta; Rozema, J.; Abass, Ahmed

doi:10.1111/opo.13020

Cited by 7 publications

(3 citation statements)

References 48 publications

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“…In the same line of work, Consejo et al investigated whether corneal tilt might be a confounding factor affecting corneal densitometry readings [27]. They found a minor but statistically significant effect of corneal tilt on corneal densitometry readings [27]. The lack of perfect symmetry in Figure 1 might be a consequence of this effect.…”

Section: Discussionmentioning

confidence: 96%

“…Their work ponders whether the commonly accepted correlation of corneal densitometry with age is an artifact caused by intrinsic age-related biometry changes in anterior chamber depth or pupil size [19]. In the same line of work, Consejo et al investigated whether corneal tilt might be a confounding factor affecting corneal densitometry readings [27]. They found a minor but statistically significant effect of corneal tilt on corneal densitometry readings [27].…”

Section: Discussionmentioning

confidence: 99%

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Corneal Densitometry with Galilei Dual Scheimpflug Analyzer

2023

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This study aims to apply the densitometry distribution analysis (DDA) method to study corneal densitometry depending on age and corneal region from Galilei Dual Scheimpflug Analyzer tomography. A total of 83 healthy participants aged 39.02 ± 18.34 years (range 9–81 years) were screened using a Ziemer Galilei G2. Images were analysed using the DDA, and two parameters, α (corneal transparency) and β (corneal homogeneity), were estimated. A two-way ANOVA analysis was performed to investigate whether α and β are influenced by age, corneal región (four concentric areas were considered), and their interaction. The parameters α and β statistically change with age and corneal region. A statistically significant interaction effect of 13% (α) and 11% (β) exists between age and corneal region. However, the corneal region plays a more significant role than aging in corneal densitometry; 31% (α) and 51% (β) of the variance can be attributed to the corneal region, while 28% (α) and 5% (β) can be attributed solely to aging. Corneal densitometry can be objectively assessed from Galilei G2 images using the DDA method. The corneal region plays a more significant role than aging in corneal densitometry. Consequently, general results on corneal densitometry and aging should be taken cautiously.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Corneal Densitometry with Galilei Dual Scheimpflug Analyzer

2023

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“…These artefacts can arise from relatively manageable issues such as eye movement, poor fixation, scatter from light in the measurement room, and out-of-date instrument calibration. More significantly, they can also be caused by subject-related factors such as tear film instability and eye tilt [7] or, in the case of OCT densitometry, epithelial speckle [8].…”

Section: Introductionmentioning

confidence: 99%

Investigation of How Corneal Densitometry Artefacts Affect the Imaging of Normal and Keratoconic Corneas

Alanazi,

Esporcatte,

White

et al. 2024

Bioengineering

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Purpose: To investigate corneal densitometry artefacts found in Pentacam Scheimpflug scans and their potential effect on assessing keratoconic (KC) corneas compared to normal (N) corneas. Methods: The current study utilises Pentacam data of 458 N eyes, aged 35.6 ± 15.8 (range 10–87), referred to as the “N group”, and 314 KC eyes, aged 31.6 ± 10.8 (range 10–72), referred to as the “KC group”, where densitometry data were extracted and analysed via a custom-built MATLAB code. Radial summations of the densitometry were calculated at diameters ranging from 0.5 mm to 5.0 mm. The minimum normalised radial summation of densitometry (NRSD) value and angle were determined at each diameter and then linked. KC cone locations and areas of pathology were determined, and a comparison between N and KC groups was carried out both within the averaged area of pathology and over the corneal surface. Results: Joining minimum NRSD trajectory points marked a clear distortion line pointing to the nasal-superior direction at 65° from the nasal meridian. The findings were found to be independent of eye laterality or ocular condition. Consistency was detected in the right and left eyes among both the N and KC groups. The location of the KC cone centre and the area of pathology were determined, and the densitometry output was compared both within the area of pathology and over the whole cornea. When the average densitometry was compared between N and KC eyes within the KC area of pathology, the N group recorded a 16.37 ± 3.15 normalised grey-scale unit (NGSU), and the KC group recorded 17.74 ± 3.4 NGSU (p = 0.0001). However, when the whole cornea was considered, the N group recorded 16.71 ± 5.5 NGSU, and the KC group recorded 15.72 ± 3.98 NGSU (p = 0.0467). A weak correlation was found between the Bad D index and NGSU when the whole measured cornea was considered (R = −0.01); however, a better correlation was recorded within the KC area of pathology (R = 0.21). Conclusions: Nasal-superior artefacts are observed in the densitometry Pentacam maps, and analysis shows no significant differences in their appearance between N or KC corneas. When analysing KC corneas, it was found that the cone positions are mostly on the temporal-inferior side of the cornea, opposite to the densitometry artefact NRSD trajectory. The analysis suggests that the corneal densitometry artefacts do not interfere with the KC area of pathology as it reaches its extreme in the opposite direction; therefore, weighting the densitometry map to increase the contribution of the inferior-temporal cornea and decreasing that of the superior-nasal area would improve the classification or identification of KC if densitometry is to be used as a KC metric.

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Corneal densitometry: A new evaluation indicator for corneal diseases

Yang,

Ju,

2025

Survey of Ophthalmology

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Influence of eye tilt on corneal densitometry

Cited by 7 publications

References 48 publications

Corneal Densitometry with Galilei Dual Scheimpflug Analyzer

Corneal Densitometry with Galilei Dual Scheimpflug Analyzer

Investigation of How Corneal Densitometry Artefacts Affect the Imaging of Normal and Keratoconic Corneas

Corneal densitometry: A new evaluation indicator for corneal diseases

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