Influence of factors on mammographic density in premenopausal Chinese women

Yang, Yaping; Liu, Jieqiong; Gu, Ran; Hu, Yue; Liu, Fengtao; Yun, Miaomiao; Xiao, Qing; Wu, Mei; Liu, Qiang; Su, Fengxi

doi:10.1097/cej.0000000000000177

Cited by 23 publications

(43 citation statements)

References 29 publications

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“…There was also variability between studies in the questions used to assess alcohol intake, and in the units in which alcohol intake was measured. Several studies (19,24,26,(28)(29)(30)33) noted that alcohol consumption was low within the study population, which may have influenced the results, and there were six studies (20-23, 36, 40) with less than 300 participants. These uncontrolled sources of variation are reflected in the tests of heterogeneity that were statistically significant in all three groups of studies and remained significant in the sensitivity analyses.…”

Section: Discussionmentioning

confidence: 99%

“…All studies in groups 1 and 2 adjusted coefficients for body mass index (BMI) or weight, and only two studies, both in group 3, did not adjust for BMI or weight (33,36).…”

Section: Discussionmentioning

confidence: 99%

“…The definition of "no alcohol use" varied between studies, but in general meant that the individual did not consume alcohol at the time of the study (18,(31)(32)(33). No study used a category of "never used alcohol," and the "no alcohol use" category may thus have included former users, which is likely to attenuate associations of BD with alcohol use.…”

Section: Measurement Of Alcohol Consumptionmentioning

confidence: 99%

“…Other forms of dietary assessment included in-person dietary history interviews (20,24,29,30,33,37,38), dietary history questionnaires (17-19, 22, 23, 26, 28, 34), and a 7-day food diary (32).…”

Section: Measurement Of Alcohol Consumptionmentioning

confidence: 99%

“…[31][32][33][34][35][36]. Three studies (32,35,36) used Wolfe's classification of parenchymal patterns and three (31,33,34) used the BIRADS classification of PBD. Three of the six studies reported positive statistically significant associations between alcohol consumption and PBD.…”

Section: Group 3: Meta-analysis Of Studies Using Qualitative Measuresmentioning

confidence: 99%

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The Association between Alcohol Consumption and Breast Density: A Systematic Review and Meta-analysis

Ziembicki

Zhu

Tse

et al. 2017

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Percent breast density (PBD) is a strong risk factor for breast cancer that is influenced by several other risk factors for the disease. Alcohol consumption is associated with an increased risk of breast cancer with an uncertain association with PBD. We have carried out a systematic review and metaanalysis to examine the association of alcohol consumption with PBD.Methods: We searched nine databases to identify all relevant studies on the association between alcohol intake and breast density. Two independent investigators evaluated and selected 20 studies that were included in our analyses. We divided the studies into three groups according to the methods used to measure and analyze the association of breast density with alcohol consumption.

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Section: Discussionmentioning

confidence: 99%

“…All studies in groups 1 and 2 adjusted coefficients for body mass index (BMI) or weight, and only two studies, both in group 3, did not adjust for BMI or weight (33,36).…”

Section: Discussionmentioning

confidence: 99%

Section: Measurement Of Alcohol Consumptionmentioning

confidence: 99%

Section: Measurement Of Alcohol Consumptionmentioning

confidence: 99%

Section: Group 3: Meta-analysis Of Studies Using Qualitative Measuresmentioning

confidence: 99%

See 3 more Smart Citations

The Association between Alcohol Consumption and Breast Density: A Systematic Review and Meta-analysis

Ziembicki

Zhu

Tse

et al. 2017

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Family History of Breast Cancer and Mammographic Breast Density in Premenopausal Women

et al. 2022

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IMPORTANCE Family history of breast cancer (FHBC) and mammographic breast density are independent risk factors for breast cancer, but the association of FHBC and mammographic breast density in premenopausal women is not well understood.OBJECTIVES To investigate the association of FHBC and mammographic breast density in premenopausal women using both quantitative and qualitative measurements. DESIGN, SETTING, AND PARTICIPANTSThis single-center cohort study examined 2 retrospective cohorts: a discovery set of 375 premenopausal women and a validation set of 14 040 premenopausal women. Data from women in the discovery set was collected between December 2015 and October 2016, whereas data from women in the validation set was collected between June 2010 and December 2015. Data analysis was performed between June 2018 and June 2020. EXPOSURES Family history of breast cancer (FHBC). MAIN OUTCOMES AND MEASURESThe primary outcomes were mammographic breast density measured quantitatively as volumetric percent density using Volpara (discovery set) and qualitatively using BI-RADS (Breast Imaging Reporting and Data System) breast density (validation set).Multivariable regressions were performed using a log-transformed normal distribution for the discovery set and a logistic distribution for the validation set. RESULTSOf 14 415 premenopausal women included in the study, the discovery set and validation set had similar characteristics (discovery set with FHBC: mean [SD] age, 47.1 [5.6] years; 15 [17.2%] were Black or African American women and 64 [73.6%] were non-Hispanic White women; discovery set with no FHBC: mean [SD] age, 47.7 [4.5] years; 87 [31.6%] were Black or African American women and 178 [64.7%] were non-Hispanic White women; validation set with FHBC: mean [SD] age, 46.8 [7.3] years; 720 [33.4%] were Black or African American women and 1378 [64.0%] were non-Hispanic White women]; validation set with no FHBC: mean [SD] age, 47.5 [6.1] years; 4572 [38.5%] were Black or African American women and 6632 [55.8%] were non-Hispanic White women]). In the discovery set, participants who had FHBC were more likely to have a higher mean volumetric percent density compared with participants with no FHBC (11.1% vs 9.0%). In the multivariable-adjusted model, volumetric percent density was 25% higher (odds ratio [OR], 1.25 ;95% CI, 1.12-1.41) in women with FHBC compared with women without FHBC; and 24% higher (OR, 1.24; 95% CI, 1.10-1.40) in women who had 1 affected relative, but not significantly higher in women who had at least 2 affected relatives (OR, 1.40; 95% CI, 0.95-2.07) compared with women with no relatives affected. In the validation set, women with a positive FHBC were more likely to have dense breasts (BI-RADS 3-4) compared with women with no FHBC (BI-RADS 3: 41.1% vs 38.8%; BI-RADS 4: 10.5% vs 7.7%). In the multivariable-adjusted model, the odds of having dense breasts (BI-RADS 3-4) were 30% higher (OR, 1.30; 95% CI, 1.17-1.45) in women with FHBC compared with women (continued) Key Points Question Is family history of b...

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Association of Breast Cancer Family History With Breast Density Over Time in Korean Women

et al. 2023

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ImportanceEvidence suggests that women with a family history of breast cancer (FHBC) in first-degree relatives have a higher level of breast density; however, studies of premenopausal women remain limited.ObjectiveTo investigate the association between FHBC and mammographic breast density and breast density changes among premenopausal women.Design, Setting, and ParticipantsThis retrospective cohort study used population-based data obtained from the National Health Insurance Service–National Health Information Database of Korea. We included premenopausal women aged 40 to 55 years who underwent mammography for breast cancer screening once between January 1, 2015, and December 31, 2016 (n = 1 174 214), and women who underwent mammography twice (first in 2015-2016 and again between January 1, 2017 and December 31, 2018) (n = 838 855).ExposuresFamily history of breast cancer was assessed using a self-reported questionnaire, which included information on FHBC in the mother and/or sister.Main Outcomes and MeasuresBreast density, based on the Breast Imaging Reporting and Data System, was categorized as dense (heterogeneously or extremely dense) and nondense (almost entirely fat or scattered fibroglandular areas). Multivariate logistic regression was used to assess the association among FHBC, breast density, and changes in breast density from the first to second screening. Data analysis was performed from June 1 to September 31, 2022.ResultsOf the 1 174 214 premenopausal women, 34 003 (2.4%; mean [SD] age, 46.3 [3.2] years) reported having FHBC among their first-degree relatives, and 1 140 211 (97.1%; mean [SD] age, 46.3 [3.2] years) reported no FHBC. Odds of having dense breasts was 22% higher (adjusted odds ratio [aOR], 1.22; 95% CI, 1.19-1.26) in women with FHBC than in women without FHBC, and the association varied by affected relatives: mother alone (aOR, 1.15; 95% CI, 1.10-1.21), sister alone (aOR, 1.26; 95% CI, 1.22-1.31), and both mother and sister (aOR, 1.64; 95% CI, 1.20-2.25). Among women with fatty breasts at baseline, the odds of developing dense breasts was higher in women with FHBC than in those without FHBC (aOR, 1.19; 95% CI, 1.11-1.26), whereas among women with dense breasts, higher odds of having persistently dense breasts were observed in women with FHBC (aOR, 1.11; 95% CI, 1.05-1.16) than in those without FHBC.Conclusions and RelevanceIn this cohort study of premenopausal Korean women, FHBC was positively associated with an increased incidence of having increased or persistently dense breasts over time. These findings suggest the need for a tailored breast cancer risk assessment for women with FHBC.

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Influence of factors on mammographic density in premenopausal Chinese women

Cited by 23 publications

References 29 publications

The Association between Alcohol Consumption and Breast Density: A Systematic Review and Meta-analysis

The Association between Alcohol Consumption and Breast Density: A Systematic Review and Meta-analysis

Family History of Breast Cancer and Mammographic Breast Density in Premenopausal Women

Association of Breast Cancer Family History With Breast Density Over Time in Korean Women

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