Influence of fasting on glycogen depletion in rats during exercise

Dohm, G. Lynis; Tapscott, Edward B.; Barakat, Heba; Kasperek, George J.

doi:10.1152/jappl.1983.55.3.830

Cited by 69 publications

(47 citation statements)

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“…Exercise caused less, if any, glycogen depletion in red muscles of 48 h-starved rats than it did in fed controls, in keeping with the findings of others (Dohm et al, 1983). Pre-exercise glycogen contents were lower in the starved group, however.…”

supporting

confidence: 90%

Effects of starvation and exercise on concentrations of citrate, hexose phosphates and glycogen in skeletal muscle and heart. Evidence for selective operation of the glucose-fatty acid cycle

Zorzano¹,

Balon²,

Brady³

et al. 1985

Biochemical Journal

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1. Concentrations of citrate, hexose phosphates and glycogen were measured in skeletal muscle and heart under conditions in which plasma non-esterified fatty acids and ketone bodies were physiologically increased. The aim was to determine under what conditions the glucose-fatty acid cycle might be operative in skeletal muscle in vivo. 2. In keeping with the findings of others, starvation increased the concentrations of glycogen, citrate and the fructose 6-phosphate/fructose 1,6-bisphosphate ratio in heart, indicating that the cycle was operative. In contrast, it decreased glycogen and had no effect on the concentration of citrate or the fructose 6-phosphate/fructose 1,6-bisphosphate ratio in the soleus, a slow-twitch red muscle in which the glucose-fatty acid cycle has been demonstrated in vitro. 3. In fed rats, exercise of moderate intensity caused glycogen depletion in the soleus and red portion of gastrocnemius muscle, but not in heart. In starved rats the same exercise had no effect on the already diminished glycogen contents in skeletal muscle, but it decreased cardiac glycogen by 2530% . 4. After exercise, citrate and the fructose 6-phosphate/fructose 1,6-bisphosphate ratio were increased in the soleus of the starved rat. Significant changes were not observed in fed rats. 5. The data suggest that in the resting state the glucose-fatty acid cycle operates in the heart, but not in the soleus muscle, of a starved rat. In contrast, the metabolite profile in the soleus was consistent with activation of the glucose-fatty acid cycle in the starved rat during the recovery period after exercise. Whether the cycle operates during exercise itself is unclear.

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supporting

confidence: 90%

Effects of starvation and exercise on concentrations of citrate, hexose phosphates and glycogen in skeletal muscle and heart. Evidence for selective operation of the glucose-fatty acid cycle

Zorzano¹,

Balon²,

Brady³

et al. 1985

Biochemical Journal

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“…Wilber (1959) reported that severe depletion of liver glycogen was noted in all guinea pigs that swam to exhaustion. Liver glycogen depletion might be an important factor in the development of fatigue because as liver glycogen is depleted during exercise there is an inability to maintain blood glucose level, and the ensuing hypoglycemia could result in impaired nervous function (Dohm et al, 1983). Dohm et al (1983) also demonstrated the importance of muscle glycogen levels in endurance exercise and suggested that depletion of muscle glycogen was a factor in fatigue and exhaustion (Jung et al, 2004).…”

Section: Resultsmentioning

confidence: 99%

Glabridin from Chinese herb licorice inhibits fatigue in mice

Shang¹,

Cao²,

Wang³

et al. 2010

Afr. J. Trad. Compl. Alt. Med.

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The inhibiting effect of glabridin from Chinese herb Licorice on fatigue was investigated in male BALB/c mice. Mice were divided into the following 4 experimental groups: control group (CG), low dose group (LG), middle dose group (MG) and high dose group (HG,). The control group was given 0.5% Tween 80 solution and the treatment groups (LG, MG, HG) were given various doses of glabridin (5, 10, 20 mg/kg) for 28 consecutive days. Body mass, blood lactic acid (BLA), serum blood urea nitrogen (BUN), liver glycogen and muscle glycogen concentrations in mice were determined. Results showed that glabridin significantly inhibited fatigue, which extended the exhaustive exercise time of mice, effectively delayed the elevation of blood lactic acid and increase in the storage of liver and muscle glycogen.

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“…Liver glycogen and muscle glycogen levels depletion might be an important factor in the development of fatigue because as glycogen is depleted during high-intensity exercise, then there is an inability to maintain blood glucose level, which result in fatigue and exhaustion. 22) Results from this study showed that mice in 1-BCP groups significantly increased their liver glycogen and muscle glycogen levels, compared with control group, indicating 1-BCP enhance the exercise endurance may owing to increased the storage of liver glycogen. Moreover, there is a dose-dependent effect between 1-BCP-H and 1-BCP-L (p<0.05), which is another confirmation that 1-BCP has the anti-fatigue effects.…”

Section: )mentioning

confidence: 60%

1-(1,3-Benzodioxol-5-yl-carbo-nyl) Piperidine, a Modulator of α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid Receptor, Ameliorates Exercise-Induced Fatigue in Mice

Pan

et al. 2014

Biological & Pharmaceutical Bulletin

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The current study was designed to investigate the effects of 1-(1,3-benzodioxol-5-yl-carbonyl) piperidine (1-BCP) on swimming endurance capacity which as one indicator of fatigue in the weight-loaded forced swimming mice. Mice were given either vehicle or 1-BCP (0.1, or 0.2 mmol/kg body weight daily) by intraperitoneal injection once daily for 2 weeks. The 1-BCP groups showed a significant increase in swimming time to exhaustion compared with the control group. 1-BCP increased the liver glycogen (LG) and muscle glycogen (MG) contents significantly, while decreased the lactic acid (LA) and blood urea nitrogen (BUN) levels notably compared with control group. Besides, 1-BCP treatment also significantly improved the endogenous cellular antioxidant enzymes in mice by increasing the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px). Therefore, this study demonstrated for the first time that the supplementation of 1-BCP, as a positive allosteric modulator of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor, could enhance the endurance capacity of mice and facilitated them recovery from fatigue. Thus, we provide a new effective therapeutic strategy for fatigue.Key words 1-(1,3-benzodioxol-5-yl-carbonyl) piperidine; fatigue; endurance capacity; weight-loaded forced swimming; α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor modulator Fatigue is best defined as the difficulties in initiating or sustaining voluntary activities, and can be classified into mental and physical subcategories. Fatigue is usually accompanied by deterioration in performance, which is resulted from several stress and hard physical or mental work.1,2) It is one of the most frequent symptoms and most disabling nonmotor problems in the modern society and would generate severe negative consequences on cognition, physical performance function, and quality of life in patients with the Parkinson's disease.3) Unfortunately, there have not been few medications to treat fatigue, and the current therapeutic stategies for relieving fatigue have not been effective enough.3)Persons at risk for impaired performance and health-related issues resulting from fatigue would benefit from agents capable of reducing these detrimental effects during they are fatigue. These agents could produce anti-fatigue effects by supplying energy substances, accelerating the elimination of metabolic products, adjusting the internal environment, enhancing body immunity or directly stimulating the nervous system. 4) A series of alertness-enhancing compounds that have been utilized to combat the fatigue, including methamphetamine, amphetamine, caffeine, and modafinil. However, a number of literatures reported their side effects, such as the potential to addiction and potent stimulant actions, which can distort cognitive and sensory processes at doses required to counteract the effects of fatigue. 5,6) In addition, selective serotonin reuptake inhibitors have been utilized to treat chronic fatigue syndrome. The...

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Influence of fasting on glycogen depletion in rats during exercise

Cited by 69 publications

References 0 publications

Effects of starvation and exercise on concentrations of citrate, hexose phosphates and glycogen in skeletal muscle and heart. Evidence for selective operation of the glucose-fatty acid cycle

Effects of starvation and exercise on concentrations of citrate, hexose phosphates and glycogen in skeletal muscle and heart. Evidence for selective operation of the glucose-fatty acid cycle

Glabridin from Chinese herb licorice inhibits fatigue in mice

1-(1,3-Benzodioxol-5-yl-carbo-nyl) Piperidine, a Modulator of α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid Receptor, Ameliorates Exercise-Induced Fatigue in Mice

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