Influence of fatty acid ethanolamides and Δ9-tetrahydrocannabinol on cytokine and arachidonate release by mononuclear cells

Berdyshev, E.V.; Boichot, Elisabeth; Germain, Nicolas; Allain, Nathalie; Anger, Jean-Pierre; Lagente, Vincent

doi:10.1016/s0014-2999(97)01007-8

Cited by 162 publications

(109 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Indeed, it is the precursor of the class of bioactive molecules consisting of the proinflammatory eicosanoids. Anandamide stimulates AA release in monocytes (Berdyshev et al, 1997). Anandamide induces AA release from J774 mouse macrophages, and this is blocked by pertussis toxin, an inhibitor of G i/o proteins .…”

Section: Aa Releasementioning

confidence: 94%

See 1 more Smart Citation

Cannabinoids and neuroinflammation

Walter

Stella

2004

British J Pharmacology

305

215

View full text Add to dashboard Cite

Growing evidence suggests that a major physiological function of the cannabinoid signaling system is to modulate neuroinflammation. This review discusses the anti-inflammatory properties of cannabinoid compounds at molecular, cellular and whole animal levels, first by examining the evidence for anti-inflammatory effects of cannabinoids obtained using in vivo animal models of clinical neuroinflammatory conditions, specifically rodent models of multiple sclerosis, and second by describing the endogenous cannabinoid (endocannabinoid) system components in immune cells. Our aim is to identify immune functions modulated by cannabinoids that could account for their antiinflammatory effects in these animal models.

show abstract

Section: Aa Releasementioning

confidence: 94%

“…Anandamide inhibits proinflammatory TNFa production, inhibits cytokine soluble receptors, and inhibits IL-6 and IL-8 in LPS-stimulated monocytes (Berdyshev et al, 1997). 2-AG inhibits TNFa production from mouse macrophages (Gallily et al, 2000).…”

Section: Proliferation and Chemotaxismentioning

confidence: 99%

Cannabinoids and neuroinflammation

Walter

Stella

2004

British J Pharmacology

305

215

View full text Add to dashboard Cite

show abstract

“…Unlabeled ethanolamine and calcium ionophore A23187 were from Sigma (St. Louis, MO, USA). [1,[2][3][4][5][6][7][8][9][10][11][12][13][14] C]Ethanolamine (speci¢c activity, 2.5 mCi/ mmol) was from NEN Life Science Products (USA). L-Glutamine and all other chemicals used in the incubation experiments were analytical grade from Wako Pure Chemical Industries (Osaka, Japan).…”

Section: Methodsmentioning

confidence: 99%

Biosynthesis and turnover of anandamide and other N‐acylethanolamines in peritoneal macrophages

et al. 1999

View full text Add to dashboard Cite

Polyunsaturated N-acylethanolamines (NAEs), including anandamide (20 :4n3 36 NAE), elicit a variety of biological effects through cannabinoid receptors, whereas saturated and monounsaturated NAEs are inactive. Arachidonic acid mobilization induced by treatment of intact mouse peritoneal macrophages with Ca 2+ ionophore A23187 had no effect on the production of NAE or its precursor N-acylphosphatidylethanolamine (N-acyl PE). Addition of exogenous ethanolamine resulted in enhanced NAE synthesis by its Nacylation with endogenous fatty acids, but this pathway was not selective for arachidonic acid. Incorporation of 18 O from H 2 18 O-containing media into the amide carbonyls of both NAE and N-acyl PE demonstrated a rapid, constitutive turnover of both lipids.z 1999 Federation of European Biochemical Societies.

show abstract

“…N-Palmitoylethanolamine has anti-inflammatory (13)(14)(15), anti-nociceptive (16,17), immunosuppressive (18), neuroprotective (19), and antioxidant (20) effects. Recently, it was shown that the anti-inflammatory action of N-palmitoylethanolamine could be mediated by the activation of peroxisome proliferator-activated receptor-␣ (PPAR-␣) (21).…”

mentioning

confidence: 99%

Molecular Characterization of N-Acylethanolamine-hydrolyzing Acid Amidase, a Novel Member of the Choloylglycine Hydrolase Family with Structural and Functional Similarity to Acid Ceramidase

Tsuboi

Sun

Okamoto

et al. 2005

Journal of Biological Chemistry

298

287

View full text Add to dashboard Cite

Bioactive N-acylethanolamines, including anandamide (an endocannabinoid) and N-palmitoylethanolamine (an anti-inflammatory and neuroprotective substance), are hydrolyzed to fatty acids and ethanolamine by fatty acid amide hydrolase. Moreover, we found another amidohydrolase catalyzing the same reaction only at acidic pH, and we purified it from rat lung (Ueda, N., Yamanaka, K., and Yamamoto, S. (2001) J. Biol. Chem. 276, 35552-35557). Here we report complementary DNA cloning and functional expression of the enzyme termed "N-acylethanolamine-hydrolyzing acid amidase (NAAA)" from human, rat, and mouse. The deduced primary structures revealed that NAAA had no homology to fatty acid amide hydrolase but belonged to the choloylglycine hydrolase family. Human NAAA was essentially identical to a gene product that had been noted to resemble acid ceramidase but lacked ceramide hydrolyzing activity. The recombinant human NAAA overexpressed in HEK293 cells hydrolyzed various N-acylethanolamines with N-palmitoylethanolamine as the most reactive substrate. Most interestingly, a very low ceramide hydrolyzing activity was also detected with NAAA, and N-lauroylethanolamine hydrolyzing activity was observed with acid ceramidase. By the use of tunicamycin and endoglycosidase, NAAA was found to be a glycoprotein. Furthermore, the enzyme was proteolytically processed to a shorter form at pH 4.5 but not at pH 7.4. Expression analysis of a green fluorescent protein-NAAA fusion protein showed a lysosome-like distribution in HEK293 cells. The organ distribution of the messenger RNA in rats revealed its wide distribution with the highest expression in lung. These results demonstrated that NAAA is a novel N-acylethanolamine-hydrolyzing enzyme that shows structural and functional similarity to acid ceramidase.

show abstract

Influence of fatty acid ethanolamides and Δ9-tetrahydrocannabinol on cytokine and arachidonate release by mononuclear cells

Cited by 162 publications

References 45 publications

Cannabinoids and neuroinflammation

Cannabinoids and neuroinflammation

Biosynthesis and turnover of anandamide and other N‐acylethanolamines in peritoneal macrophages

Molecular Characterization of N-Acylethanolamine-hydrolyzing Acid Amidase, a Novel Member of the Choloylglycine Hydrolase Family with Structural and Functional Similarity to Acid Ceramidase

Contact Info

Product

Resources

About