Influence of Fe3O4 Nanoparticles in Hydroxyapatite Scaffolds on Proliferation of Primary Human Fibroblast Cells

Maleki-Ghaleh, H.; Aghaie, Ermia; Nadernezhad, Ali; Zargarzadeh, Mehrzad; Khakzad, A.; Shakeri, Mohammad Sadegh; Khosrowshahi, Younes Beygi; Siadati, M. H.

doi:10.1007/s11665-016-2086-4

Cited by 24 publications

(18 citation statements)

References 37 publications

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“…According to the method, reagents and variables adopted, it is possible to obtain materials based on CaP with different phases, which results in materials with diverse characteristics and properties, such as crystalline defects, high surface area, organic material affinity found in physiological medium and so on [46]. HAp can be synthesized by a variety of techniques that can be broadly grouped into six sets of methods: i) dry methods: involve solid state and mechanochemical reactions [63][64][65][66][67]; ii) wet methods: based on low-temperature chemical precipitation [68], co-precipitation [66,69,70], sol-gel route [71][72][73][74][75][76] and hydrolysis [77,78]; iii) hydrothermal methods: use aqueous solutions of high temperature and high voltage, as hydrothermal [79][80][81], emulsion and microemulsion [82,83], and sonochemical [84]; iv) high temperature processes: include combustion [85,86] and pyrolysis [87,88]; v) synthesis based on biogenic sources: can be extracted from fish bones [89], shells [90], eggshells [91,92], bovine bones [93,94], in the presence of biomolecules [95][96][97] or biomembranes [98]; and vi) combination of the aforementioned methods. All methods used for synthesizing HAp particles have different processing characteristics and can result ...…”

Section: Synthesis Of Hydroxyapatitementioning

confidence: 99%

“…In vitro biocompatibility studies using osteoblasts (MG63) and fibroblast cells (NIH 3T3) indicated the non-toxic nature of the obtained HAp powder. HAp can be extracted from bovine cortical bone by performing heat treatment at high temperature in order to synthesize HAp powder, followed by milling to obtain particles in the desired size [93,94].…”

Section: Synthesis By Biogenic Sourcesmentioning

confidence: 99%

“…) [241], as well as extra components like silver nanoparticles [242], carbon nanotubes [243][244][245][246], graphene and graphene oxide [247,248], or magnetic nanoparticles (Fe 3 O 4 ) [93,94,249]. The presence of these dopants in HAp structure significantly contributes to the biostructure and biochemistry, similar to a natural bone [250].…”

Section: -mentioning

confidence: 99%

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A brief review on hydroxyapatite production and use in biomedicine

et al. 2019

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Hydroxyapatite (HAp) is a bioceramic widely studied due to its chemical similarity with the mineral component of bones. Besides, it is biocompatible, bioactive and thermodynamically stable in the body fluid what poses it as an attractive material for a wide range of applications in the biomedical field. Several efforts have been focused on the synthesis of particles of this material aiming to the precise control of size and morphology, porosity and surface area. HAp is widely used as an implant for bone tissue regeneration, as a coating for metallic implants and in a drug-controlled release. In this sense, the objective of this review is to gather information related to HAp, providing readers with information about synthesis methods, material characteristics and their applications.

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Section: Synthesis Of Hydroxyapatitementioning

confidence: 99%

Section: Synthesis By Biogenic Sourcesmentioning

confidence: 99%

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A brief review on hydroxyapatite production and use in biomedicine

et al. 2019

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“…When the particle size is less than 30 nm in diameter, the thermal fluctuation energy is equivalent to the magnetocrystalline anisotropy energy, which is enough to cause the whole crystallite to rotate freely, thereby exhibiting superparamagnetism [ 21 , 22 ]. Even if no external magnetic field is applied, the superparamagnetic Fe 3 O 4 nanoparticle can be regarded as a single magnetic domain without a domain wall, providing a micro-magnetic source for the nano-scale magnetic field [ 23 , 24 ]. In addition, Fe 3 O 4 nanoparticles approved by the Food and Drug Administration (FDA) of United States of America for clinical use, have excellent biocompatibility and safety, and are widely used in bone tissue engineering [ 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Micro Magnetic Field Produced by Fe3O4 Nanoparticles in Bone Scaffold for Enhancing Cellular Activity

et al. 2020

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The low cellular activity of poly-l-lactic acid (PLLA) limits its application in bone scaffold, although PLLA has advantages in terms of good biocompatibility and easy processing. In this study, superparamagnetic Fe3O4 nanoparticles were incorporated into the PLLA bone scaffold prepared by selective laser sintering (SLS) for continuously and steadily enhancing cellular activity. In the scaffold, each Fe3O4 nanoparticle was a single magnetic domain without a domain wall, providing a micro-magnetic source to generate a tiny magnetic field, thereby continuously and steadily generating magnetic stimulation to cells. The results showed that the magnetic scaffold exhibited superparamagnetism and its saturation magnetization reached a maximum value of 6.1 emu/g. It promoted the attachment, diffusion, and interaction of MG63 cells, and increased the activity of alkaline phosphatase, thus promoting the cell proliferation and differentiation. Meanwhile, the scaffold with 7% Fe3O4 presented increased compressive strength, modulus, and Vickers hardness by 63.4%, 78.9%, and 19.1% compared with the PLLA scaffold, respectively, due to the addition of Fe3O4 nanoparticles, which act as a nanoscale reinforcement in the polymer matrix. All these positive results suggested that the PLLA/Fe3O4 scaffold with good magnetic properties is of great potential for bone tissue engineering applications.

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“…The connection of the cells with the surface leads to creating communication and signaling between the cell and the HA coating, which can increase cell proliferation . By increasing the cell proliferation at the interface between the surface of the HA and the culture medium, cell proliferation of the medium will be enhanced by the effect of the increased cells at the culture medium‐coating interface due to the intercellular signals . The presence of the TiO 2 , CaTiO 3 , and Ca 3 (PO 4 ) 2 phases and MWCNTs particles in the HA coating increased the amount of ions absorbed from the culture medium, which is due to the difference in the value of the PZC of these phases compared with the HA .…”

Section: Resultsmentioning

confidence: 99%

Effect of hydroxyapatite‐titanium‐MWCNTs composite coating fabricated by electrophoretic deposition on corrosion and cellular behavior of NiTi alloy

Maleki-Ghaleh

Khalil‐Allafi

2019

Materials & Corrosion

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In this study, the hydroxyapatite (HA)‐titanium (Ti, 20 wt.%) multiwalled carbon nanotubes (MWCNTs, 1 wt.%) composite coating was applied on the NiTi alloy by using the electrophoretic deposition (EPD) technique. The morphologies and the phase structures of the coatings were investigated by the FESEM and XRD analysis, respectively. The corrosion behaviors of the coated NiTi samples were investigated using the polarization and electrochemical impedance spectroscopy tests in a simulated body fluid (SBF). The amounts of the released Ni ions from the coated NiTi were studied in the SBF. The results of the electrochemical tests revealed the corrosion resistance of the NiTi coated with HA was further improved by the addition of the Ti and MWCNTs to the HA coating. The current density and corrosion resistance of the NiTi alloy changed from 2.52 μA.cm−2 and 24.13 kΩ to 0.91 nA.cm−2 and 5.92 MΩ after coated with the HA‐Ti‐MWCNTs composite coating. Also, the number of nickel ions released from the surface of the NiTi alloy to the SBF medium suppressed from 11.8 to 0.08 μgr.L−1, after coating with HA‐Ti‐MWCNTs. Also, the cellular proliferation in the culture medium consisting of the NiTi alloy coated with the HA‐Ti‐MWCNTs improved significantly (compared with that of the NiTi alloy) as shown no toxicity in the cell culture medium.

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Influence of Fe3O4 Nanoparticles in Hydroxyapatite Scaffolds on Proliferation of Primary Human Fibroblast Cells

Cited by 24 publications

References 37 publications

A brief review on hydroxyapatite production and use in biomedicine

A brief review on hydroxyapatite production and use in biomedicine

Micro Magnetic Field Produced by Fe3O4 Nanoparticles in Bone Scaffold for Enhancing Cellular Activity

Effect of hydroxyapatite‐titanium‐MWCNTs composite coating fabricated by electrophoretic deposition on corrosion and cellular behavior of NiTi alloy

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