Influence of Female Sex Hormones in Different Stages of Women on Periodontium

Boyapati, Ramanarayana; Cherukuri, SaiAbhishiktha; Bodduru, Ruparani; Kiranmaye, Ambati

doi:10.4103/jmh.jmh_142_21

Cited by 16 publications

(14 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These findings agree with these studies Mohammed et al (24) , Al-dhaher et al (25) . The reason behind that because female was more prone to incipience and advancement of gingivitis and periodontal diseases that their sex hormones causes alteration in bacterial flora (26) . Descriptive statistics of clinical parameter (PI) findings agree with other studies (27,28) .…”

Section: Discussionmentioning

confidence: 99%

Association between The Cytokine IL-23 in Saliva with Periodontal Health and Disease

Kamil¹,

Ali²

2023

The Egyptian Journal of Hospital Medicine

View full text Add to dashboard Cite

Background: In the term of the prevalence of chronic inflammatory conditions manipulating human beings, periodontal diseases were the predominant. Cytokines are proteins of low molecular weight responsible for the inception of inflammatory response and further stages of it in which they coordinate the extent and the duration of the response. IL-23 is a member of a heterodimeric IL-12 cytokine family, generated from macrophages and dendritic cells after the exposure to bacterial pathogens. Saliva is a hypotonic solution formed by the salivary glands, gingival crevicular fluid, and oral mucosal exudate.Objective: this study aimed to find the association of salivary concentration of IL-23 with periodontal health and disease by examining its' level in individuals with healthy periodontium, with dental biofilm-induced gingivitis and periodontitis (localized and generalized). Patient and method: Saliva were collected from 90 participants with age ranged from 20-60 years. All of them were systemically healthy. 25 cases enrolled under the dental biofilm-induced gingivitis group, 25 cases under the localized periodontitis group and 25 cases under the generalized periodontitis group, with 15 subjects under healthy periodontium (control) group. Detection of IL-23 in saliva was done by Enzyme Linked Immunosorbent Assay (ELISA). Results: Our data revealed that the salivary IL-23 level was significantly (P<0.05) reduced in disease groups in comparison to healthy (control) group with a significant difference between dental biofilm-induced gingivitis and localized periodontitis groups. Conclusion: Salivary IL-23 has a significant and negative relationship with all disease groups as compared to healthy subjects.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between The Cytokine IL-23 in Saliva with Periodontal Health and Disease

Kamil¹,

Ali²

2023

The Egyptian Journal of Hospital Medicine

View full text Add to dashboard Cite

show abstract

“…Erythema, edema, hyperplasia and increasing bleeding are the manifestations of pregnancy gingivitis, the same as those for conventional gingivitis 1,2 . There is a variation from mild to severe inflammation which can progress to serious enlargement, pain and spontaneous bleeding of gingiva.…”

mentioning

confidence: 88%

“…The changes continue to do until the 8Th month of gestation, after which some enhancement occurs in the last month of gestation. In addition, the seditious changes are confined to the gingiva and presumably don't beget endless changes in periodontal tissues more frequently than those in the non-pregnant state 2 .…”

Section: Normal Mechanism Ofmentioning

confidence: 99%

Untitled

2022

IJPSR

View full text Add to dashboard Cite

Periodontitis is a multifactorial disease. It has several associations with hormonal fluctuations; the body undergoes several physiological hormonal mechanisms. In several physiological conditions, hormonal fluctuations have been observed. One such condition is pregnancy. Several hormones are at play during pregnancy; one such hormone is PTH. Parathyroid hormone is essential to increase the maternal absorption of calcium during gestation and has been observed to have a direct effect on the Periodontium. Pregnancy confers detrimental changes to the periodontal tissues in expectant mothers. In this article, we would focus on the periodontal health seen among pregnant women and how the parathyroid hormone levels vary in pregnancy in contrast to its normal mechanism. A lacuna in the literature exists, preventing us from forming an association between the varying parathyroid levels and the periodontal health status of pregnant women observed longitudinally through their pregnancies. Through this article, we aim to bridge that gap. INTRODUCTION:The dynamics between the hormonal and periodontal changes have been seen for years. Vermeeren, in 1778, described "tooth pain in pregnant women and Pitcarin discussed gingival inflammation and enlargement during pregnancy. The first case of pregnancy gingivitis was recorded by Pitcarin in 1877. The occurrence of pregnancy gingivitis has been reported to be extremely common, occurring in the range of 30% to 100% of all pregnant women.

show abstract

“…The maturation and selection of thymocytes, cell proliferation, MHC-II expression, cell migration and cytokine generation are all immunological processes that are modulated by sex hormones ( Ortiz-Sánchez et al, 2021 ). The severity of periodontal diseases can be exacerbated by immune suppression during pregnancy, including the altered lymphocyte response, suppression of T-cell activity, decreased antibody production and depressed phagocytosis and neutrophil chemotaxis ( Boyapati et al, 2021 ).…”

Section: Pregnancy Alters the Progression Of Periodontal Diseasesmentioning

confidence: 99%

The bidirectional relationship between periodontal disease and pregnancy via the interaction of oral microorganisms, hormone and immune response

Wen

Fu²,

Zhao³

et al. 2023

Front. Microbiol.

View full text Add to dashboard Cite

Periodontal disease has been suggested to be linked to adverse pregnancy outcomes such as preterm birth, low birth weight, and preeclampsia. Adverse pregnancy outcomes are a significant public health issue with important clinical and societal repercussions. This article systematically reviews the available epidemiological studies involving the relationship between periodontal disease and adverse pregnancy outcomes over the past 15 years, and finds a weak but independent association between adverse pregnancy outcomes and periodontal disease. The bidirectional association and the potential mechanisms are then explored, focusing on three possible mechanisms: inflammatory reaction, oral microorganisms and immune response. Specifically, elevated systemic inflammation and increased periodontal pathogens with their toxic products, along with a relatively suppressed immune system may lead to the disruption of homeostasis within fetal-placental unit and thus induce adverse pregnancy outcomes. This review also explains the possible mechanisms around why women are more susceptible to periodontal disease. In conclusion, pregnant women are more likely to develop periodontal disease due to hormonal changes, and periodontal disease has also been suspected to increase the incidence of adverse pregnancy outcomes. Therefore, in order to lessen the risk of adverse pregnancy outcomes, both obstetricians and dentists should pay attention to the development of periodontal diseases among women during pregnancy.

show abstract

Influence of Female Sex Hormones in Different Stages of Women on Periodontium

Cited by 16 publications

References 22 publications

Association between The Cytokine IL-23 in Saliva with Periodontal Health and Disease

Association between The Cytokine IL-23 in Saliva with Periodontal Health and Disease

Untitled

The bidirectional relationship between periodontal disease and pregnancy via the interaction of oral microorganisms, hormone and immune response

Contact Info

Product

Resources

About