Influence of Fever on Cefazolin Pharmacokinetics

Abstract

The influence of fever on the pharmacokinetics of cefazolin was investigated in patients with acute febrile diseases. Nine patients were included in the study. Antibiotic serum concentrations were determined using high performance liquid chromatograpy (HPLC). An analog computer and the SIMULINK software package were used to identify the pharmacokinetic model and PCNONLIN software package to obtain the secondary parameters. In 6 patients a two-compartment pharmacokinetic model of cefazolin was observed during fever and after defervescence. In 2 patients a two-compartment model changed to a one-compartment after defervescence, and a one-compartment model was observed in one patient during both periods. Cefazolin-treated patients with a two-compartment model (6/9) had higher Cmax, mean steady state serum concentrations (Css), and area under the plasma concentration-time curve (AUC(0-->infinity)), smaller central compartment volume (V1), and lower clearance (Cl) during fever. The varying distribution of antibiotics during fever probably reflects different hemodynamic responses to fever.

Therapeutic use of cephazolin to prevent complications of spine surgery

“…Therefore, the entry and effectiveness of some antibiotics will be infl uenced because of mutually repellant charges between the antibiotic and the proteoglycans (Currier et al, 1994;Eismont et al, 1987;Gibson et al, 1987;Thomas et al, 1995). While there are many methods for detecting cephazolin in serum and vascular organs (Beovic et al, 1999;Galanti et al, 1996;Gupta and Stewart, 1980;How et al, 1998;Hume et al, 1983;Lanao et al, 1988;Liang et al, 1994;Low et al, 2000;Polk et al;, Walker et al, 1986Watanabe et al, 1980;Wold and Turnipseed, 1977) few methods are applicable to the avascular intervertebral disc (Boscardin et al, 1992;Riley, 1998;Fraser et al, 1989). Despite the wide array of techniques for the quantifi cation of cephazolin, the current literature lacks publications relating to high-performance liquid chromatography (HPLC) methods for detecting and measuring the concentration of cephazolin in plasma and the intervertebral disc.…”

Modelling in systems biology, neurology and pharmacy

“…One-and two-compartment models were identified from the patients' data, regarding individual characteristics of patients as well as fever and defervescence. From the obtained results the following can be concluded [30][31][32]:…”

“…Extensive 'in vivo' study [30][31][32] offered enough antibiotic concentration measurements for the model development. One-and two-compartment models were identified from the patients' data, regarding individual characteristics of patients as well as fever and defervescence.…”