Influence of fibrinogen and C-RP on progression of peripheral arterial disease in type 2 diabetes: a preliminary report

Abstract

BackgroundLimited studies have suggested that inflammatory biomarkers play a role in the initiation and progression of atherosclerosis in diabetic patients. This study assesses the effect of inflammatory biomarkers: fibrinogen and C-reactive protein (C-RP) on the progression of peripheral arterial disease (PAD) in type 2 diabetic (T2D) patients.MethodsSixty two patients with T2D and PAD (mean age 60.28 ± 27 years and diabetes duration of 8.58 ± 6.17 years) were enrolled in a cohort prospective study of 36 months. Ankle-brachial index (ABI) was measured in all patients at baseline and after 36 months. Multiple linear regression analysis was used to determine the predictivity of variables for fibrinogen, C-RP, plasma lipid fractions, fasting plasma glucose, Body Mass Index (BMI), duration of diabetes status and the age on changes in ABI value.ResultsLinear regression analysis defined F as a predictor for endpoint value of ABI (β = 0.469, p = 0.007). Value of C-RP determinates change of minimal value of ABI (β = 0.449, p = 0.037) and change of mean ABI per year (β = 0.442, p = 0.025).ConclusionOur data indicate that plasma determination of fibrinogen and C-RP might have a clinical implication in defining the process of progression of PAD in T2D population.

CRP and fibrinogen imply clinical outcome of patients with Type-2 diabetes and coronary artery disease

“…Our results show that augmented CRP increases the risk for new angina. Although numerous studies have addressed the question of typical risk factors of vascular disease in Type-2 diabetic patients, so far there is no established definitive opinion regarding 'novel' risk factors [10]. Our data supports previous studies that indicate inflammatory biomarkers, CRP, and fibrinogen, as risk factors in prognostic models for patients with Type-2 diabetes and diabetic vascular disease.…”

Association between albumin and C‐reactive protein and ankle‐brachial index in haemodialysis

“…In addition, Ridker et al and Tzoulaki et al reported that CRP was associated with incident PAOD in the general population . Other studies have suggested that serum CRP may predict the progression of peripheral atherosclerosis in patients with DM and coronary artery disease . Chen et al and Matsumae et al suggested an association between serum CRP level and the incidence of PAOD in patients with chronic kidney disease and patients undergoing haemodialysis .…”

“…17,18 Other studies have suggested that serum CRP may predict the progression of peripheral atherosclerosis in patients with DM and coronary artery disease. 19,20 Chen et al and Matsumae et al suggested an association between serum CRP level and the incidence of PAOD in patients with chronic kidney disease and patients undergoing haemodialysis. 21,22 Moreover, O'Hare et al reported that PAOD in haemodialysis patients was negatively associated with serum albumin, 13 and Kuang et al reported that serum albumin level was independently associated with PAOD in elderly patients undergoing peritoneal dialysis.…”

Vascular Function in Children with Low Birthweight and Its Relationship with Early Markers of Cardiovascular Risk

“…In adulthood, elevated hs-CRP is found in the presence of endothelial dysfunction even without elevation of other markers of inflammation [34]. hs-CRP is not only considered a marker of CVD risk [35], but its elevation also increases cardiovascular damage in several pathologies [36]. The hs-CRP values measured in our LBW children have been correlated, in the adult population, with the presence of moderate cardiovascular risk [18].…”