Influence of fish consumption and some of its individual constituents on oxidative stress in cells, animals, and humans

Gabrielsson, Britt G.; Andersson, Niklas; Undeland, Ingrid

doi:10.1002/9781118855102.ch7

Cited by 1 publication

(1 citation statement)

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“…Fish oil consists mainly of unsaturated fatty acids, which are susceptible to oxidation; hence, many fish oil supplementation studies have measured oxidative stress markers. However, the findings are inconsistent, since ω-3 fatty acids seem to both promote and reduce oxidation [ 10 , 11 ]. Moreover, oxidized LDL (ox-LDL) [ 9 , 12 ] and glutathione peroxidase (GPx) [ 13 , 14 ] remain unaffected after fish consumption.…”

Section: Introductionmentioning

confidence: 99%

Consumption of Farmed Fish, Fed with an Olive-Pomace Enriched Diet, and Its Effect on the Inflammatory, Redox, and Platelet-Activating Factor Enzyme Profile of Apparently Healthy Adults: A Double-Blind Randomized Crossover Trial

Petsini

Ntzouvani

Detopoulou

et al. 2022

Foods

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A fish-rich diet has a beneficial effect on cardiovascular health. The platelet activating factor (PAF) is involved in the development of atherosclerosis, and in vitro results support the regulating action of bioactive nutrients on PAF metabolism. The purpose of this study is to examine whether the consumption of farmed fish fed with an olive-pomace enriched diet (EF) affects PAF metabolism and the markers of inflammation and oxidative stress compared to the consumption of conventionally fed farmed fish (CF). Thirty apparently healthy adults completed a randomized double-blind crossover trial, during which they consumed both CF and EF twice a week for 8 weeks with a six-week washout period in between. The activities of PAF acetylhydrolase (PAF-AH), lysoPAF acetyltransferase (lysoPAF-AT), DTT-insensitive CDP-choline: 1-alkyl-2-acetyl-sn-glycerol-choline-phosphotransferase (PAF-CPT) in leukocytes, and lipoprotein-associated phospholipase A2 (LpPLA2) in serum were determined. The quantities of interleukin-6 (IL-6), high sensitivity C-reactive protein (hsCRP), oxidized LDL (ox-LDL), thiobarbituric acid-reactive substances (TBARS), and glutathione peroxidase (GPx), as well as the serum oxidation, were also determined. Both types of fish exerted similar effects as there were no statistically significant differences between the two interventions except for an elevated PAF-CPT and reduced arachidonic acid (AA) in the red blood cell (RBC) membrane lipids after the EF intake.

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