Influence of fixed muscle length and contractile properties on atrophy and subsequent recovery in the rat soleus and plantaris muscles

Fujita, Naoto; Arakawa, Takamitsu; Matsubara, Takako; Andō, Hiroshi; Miki, Akinori

doi:10.1679/aohc.72.151

Cited by 10 publications

(10 citation statements)

References 34 publications

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“…Skeletal muscle atrophy results from a variety of conditions such as hindlimb unloading [1, 2], joint immobilization [3, 4], denervation [5, 6], and spinal cord injury [7–9]. Generally resistance exercise training is performed as an effective therapeutic intervention to prevent muscle atrophy induced by these diverse conditions.…”

Section: Introductionmentioning

confidence: 99%

The Combined Effect of Electrical Stimulation and High‐Load Isometric Contraction on Protein Degradation Pathways in Muscle Atrophy Induced by Hindlimb Unloading

Fujita

Murakami

Fujino

2011

BioMed Research International

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High-load isometric exercise is considered an effective countermeasure against muscle atrophy, but therapeutic electrical stimulation for muscle atrophy is often performed without loading. In the present study, we investigated the combined effectiveness of electrical stimulation and high-load isometric contraction in preventing muscle atrophy induced by hindlimb unloading. Electrical stimulation without loading resulted in slight attenuation of muscle atrophy. Moreover, combining electrical stimulation with high-load isometric contraction enhanced this effect. In electrical stimulation without loading, inhibition of the overexpression of calpain 1, calpain 2, and MuRF-1 mRNA was confirmed. On the other hand, in electrical stimulation with high-load isometric contraction, inhibition of the overexpression of cathepsin L and atrogin-1 mRNA in addition to calpain 1, calpain 2, and MuRF-1 mRNA was confirmed. These findings suggest that the combination of electrical stimulation and high-load isometric contraction is effective as a countermeasure against muscle atrophy.

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Section: Introductionmentioning

confidence: 99%

The Combined Effect of Electrical Stimulation and High‐Load Isometric Contraction on Protein Degradation Pathways in Muscle Atrophy Induced by Hindlimb Unloading

Fujita

Murakami

Fujino

2011

BioMed Research International

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“…Again, this may seem like a trivial point, but it should not be overlooked. For instance, previous studies have shown that the soleus is particularly prone to hindlimb suspension-induced atrophy, yet the atrophic response can be prevented if the soleus is maintained in a lengthened position [46,47]. Thus, we would like to reiterate that, as defined in this review, disuse requires a maintenance or reduction in the mean passive tension as well as a reduction in the mean active tension generated by the muscle.…”

Section: Hindlimb Suspensionmentioning

confidence: 82%

The Structural Adaptations That Mediate Disuse-Induced Atrophy of Skeletal Muscle

Sayed,

Hibbert,

Jorgenson

et al. 2023

Cells

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The maintenance of skeletal muscle mass plays a fundamental role in health and issues associated with quality of life. Mechanical signals are one of the most potent regulators of muscle mass, with a decrease in mechanical loading leading to a decrease in muscle mass. This concept has been supported by a plethora of human- and animal-based studies over the past 100 years and has resulted in the commonly used term of ‘disuse atrophy’. These same studies have also provided a great deal of insight into the structural adaptations that mediate disuse-induced atrophy. For instance, disuse results in radial atrophy of fascicles, and this is driven, at least in part, by radial atrophy of the muscle fibers. However, the ultrastructural adaptations that mediate these changes remain far from defined. Indeed, even the most basic questions, such as whether the radial atrophy of muscle fibers is driven by the radial atrophy of myofibrils and/or myofibril hypoplasia, have yet to be answered. In this review, we thoroughly summarize what is known about the macroscopic, microscopic, and ultrastructural adaptations that mediated disuse-induced atrophy and highlight some of the major gaps in knowledge that need to be filled.

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“…Skeletal muscle atrophy in type 2 diabetes is associated with physical inactivity, reduced food intake, and peripheral neuropathy. Therefore, the defects in the skeletal muscle mass of OLETF rats may have been caused by the downregulation of protein synthesis which may occur as a result of physical inactivity [34, 35], immobilization [36, 37], denervation [38], and cachexia [39]. Hyperbaric treatment does not seem to enhance structural protein synthesis in the skeletal muscle.…”

Section: Discussionmentioning

confidence: 99%

Hyperbaric Normoxia Improved Glucose Metabolism and Decreased Inflammation in Obese Diabetic Rat

Fujita

Goto

Nakamura

et al. 2019

Journal of Diabetes Research

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Hyperbaric treatment improves hyperglycemia and hyperinsulinemia in type 2 diabetes associated with obesity. However, its mode of action is unknown. The purpose of the present study was to investigate the influences of regular hyperbaric treatment with normal air at 1.3 atmospheres absolute (ATA) on glucose tolerance in type 2 diabetes with obesity. The focus was directed on inflammatory cytokines in the adipose tissue and skeletal muscle. Otsuka Long-Evans Tokushima Fatty (OLETF) rats were used as models of type 2 diabetes with obesity and Long-Evans Tokushima Otsuka (LETO) rats served as healthy controls. The rats were randomly assigned to untreated or hyperbaric treatment groups exposed to 1.3 ATA for 8 h d−1 and 5 d wk−1 for 16 wks. Glucose levels were significantly higher in the diabetic than in the healthy control rats. Nevertheless, glucose levels at 30 and 60 min after glucose administration were significantly lower in the diabetic rats treated with 1.3 ATA than in the untreated diabetic rats. Insulin levels at fasting and 120 min after glucose administration were significantly lower in the diabetic rats treated with 1.3 ATA than in the untreated diabetic rats. Hyperbaric treatment also increased interleukin-10 (IL-10) expression in the skeletal muscle and decreased tumor necrosis factor α (TNFα) expression in adipose tissue. These results suggested that TNFα downregulation and IL-10 upregulation in diabetic rats subjected to hyperbaric treatment participate in the crosstalk between the adipose and skeletal muscle tissues and improve glucose intolerance.

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Influence of fixed muscle length and contractile properties on atrophy and subsequent recovery in the rat soleus and plantaris muscles

Abstract: and HUP groups remained at day 7 although the walking ability appeared to be normal. Accordingly, further rehabilitation therapy might be necessary even if the functional ability appears to be normal.

Cited by 10 publications

References 34 publications

The Combined Effect of Electrical Stimulation and High‐Load Isometric Contraction on Protein Degradation Pathways in Muscle Atrophy Induced by Hindlimb Unloading

The Combined Effect of Electrical Stimulation and High‐Load Isometric Contraction on Protein Degradation Pathways in Muscle Atrophy Induced by Hindlimb Unloading

The Structural Adaptations That Mediate Disuse-Induced Atrophy of Skeletal Muscle

Hyperbaric Normoxia Improved Glucose Metabolism and Decreased Inflammation in Obese Diabetic Rat

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