Influence of flavonoid extracts from celery on oxidative stress induced by dichlorvos in rats

Cao, Jie; Zhang, X; Wang, Q; Li, Jia; Zhang, Y; Zhao, Xiujuan

doi:10.1177/0960327111426585

Cited by 11 publications

(5 citation statements)

References 37 publications

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“…They possess several biological and pharmacological properties that have made them useful as therapeutic agents against chemical-induced toxicity, among others. Several studies have shown flavonoids with the potential to protect against pesticide-induced toxicities [23, 24]. Epicatechin (EC) is a flavan-3-ol, a sub-class of the flavonoids found in green tea, grape, and cocoa [25].…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress and inflammation following sub-lethal oral exposure of cypermethrin in rats: mitigating potential of epicatechin

Afolabi

Aderibigbe

Folarin

et al. 2019

Heliyon

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Cypermethrin (CYP), a synthetic pyrethroid is a common environmental toxicant owing to its wide usage as a broad-spectrum insecticide. Its exposure to non-target organisms, including man, elicits numerous adverse effects making it a major public health issue. Epicatechin (EC) has proven anti-oxidative and anti-inflammatory properties. The present study was undertaken to evaluate the protective efficacy of epicatechin with regards to altered oxidative and inflammatory parameters subsequent to CYP treatment in rats. Animals were divided into four groups. The first group served as the control, while groups 2, 3, and 4 were orally treated with EC (30 mg kg À1 body weight), CYP (25 mg kg À1 body weight), and CYP plus EC, respectively. Oral administration of CYP for 14 days increased the levels of oxidative stress markers such as malondialdehyde, lipid hydroperoxides, and advanced oxidized protein products in the liver and kidney. These were accompanied by a decrease in glutathione and total antioxidant capacity levels. The activity of the enzyme superoxide dismutase was increased while catalase and glutathione peroxidase activities were decreased in these organs. Moreover, CYP increased plasma levels of the pro-inflammatory cytokines, interleukin-6 and tumor necrosis factor alpha. The plasma content of the nitrative nucleic acid marker, 8-nitroguanine was also markedly elevated by CYP. Administration of EC to CYPexposed rats mitigated the induced oxidative and inflammatory effects. These data suggest that EC can attenuate the toxic effects induced by CYP exposure.

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Section: Introductionmentioning

confidence: 99%

Oxidative stress and inflammation following sub-lethal oral exposure of cypermethrin in rats: mitigating potential of epicatechin

Afolabi

Aderibigbe

Folarin

et al. 2019

Heliyon

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“…Mosse et al have shown that winery wastewater delayed germination and inhibited vegetative growth of several plants. We have studied and shown variations of oxidative stress in bean leaves exposed to pesticides and grape marc, measuring transcript accumulations of stress gene markers, such as superoxide dismutases, catalase, ascorbate peroxidase, ubiquitin, and hsp 70, as previously described. − Agati et al recently proposed a model in which chloroplast-located flavonoids scavenge generated ROS, thus avoiding programmed cell death. They suggested that flavonoids in conjunction with peroxidases and ascorbic acid constitute a secondary antioxidant system.…”

Section: Discussionmentioning

confidence: 99%

Toxicity of Sulcotrione and Grape Marc on Vicia faba Cells

Sta

Goujon

Ferjani

et al. 2014

J. Agric. Food Chem.

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The cell toxicity of sulcotrione, a selective triketone herbicide, was evaluated on Vicia faba. Sulcotrione, trademark Mikado, grape marc, and mixtures of sulcotrione or Mikado with grape marc induced cell death. Addition of grape marc to either sulcotrione or Mikado enhanced cell death, especially with Mikado. Addition of grape marc to herbicides, sulcotrione, or Mikado resulted in different expression of genes usually associated with cell stress. Mixtures of grape marc and herbicides enhanced transcript accumulation for ubiquitin, hsp 70, and cytosolic superoxide dismutase, but did not change ascorbate peroxidase transcript accumulation. The results thus provide evidence that sulcotrione, Mikado, and mixtures with grape marc can trigger cell death and specific gene expressions. Cocktails of products with sulcotrione, such as commercial additives and grape marc, can modify biological features of pesticide. Moreover, grape marc differently enhanced cell toxicity of sulcotrione and Mikado, suggesting a synergy between pesticide products and grape marc.

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“…Research by Qian states that the flavonoid components in plants can provide benefits in improving vascular endothelial cell function in NO bioavability disorders due to glucotoxic conditions. (11) Sulforaphane as an inductor of Nrf2 has the ability to react with sulfhydryl (-SH) and Nrf2 groups bound to sulfur compounds. SFN can prevent Ang II-induced cardiomyopathy through Nrf2-mediated activation of exogenous antioxidant defenses, and regulation and activation of Nrf2 by SFN through the Akt / GSK-3β / Fyn pathway.…”

Section: Discussionmentioning

confidence: 99%

Broccoli Effects on HIF-1 in Heart Endothelial Cells of Rats that Induces Psychological Stress

Rosyidah,

Wirjatmadi,

Purwanto

2021

Indian Journal of Forensic Medicine & Toxicology

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Psychological stress possibly caused by sleep dissoder, which can cause oxidative stress. Oxidative stress can attack the heart by endothelial dysfunction. Which is expected to be reduced by administering antioxidants from steam of broccoli juiced. Broccoli known had high antioxidant activity, beside that broccoli known as one of resource of sulforaphene. Sulforaphene is an indirect antioxidant and can be an antidepressant. The purpose of this study was to determine the benefits of broccoli in reducing the number of Hif-1α expression of heart cells in male white rats wistar strain psychological stress model. This study used the Randomized Post Test Only Group Design method and statistical analysis used One Way Anova with SPSS 23. The results showed that steamed broccoli juice had a significant effect on reducing the number of Hif-1α expression in male white rat heart cells that models of psychological stress, with a sig value of 0.000 (p <0.05). So steamed broccoli juice can help reduce the risk of endothelial dysfunction caused by psychological stress.

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Influence of flavonoid extracts from celery on oxidative stress induced by dichlorvos in rats

Cited by 11 publications

References 37 publications

Oxidative stress and inflammation following sub-lethal oral exposure of cypermethrin in rats: mitigating potential of epicatechin

Oxidative stress and inflammation following sub-lethal oral exposure of cypermethrin in rats: mitigating potential of epicatechin

Toxicity of Sulcotrione and Grape Marc on Vicia faba Cells

Broccoli Effects on HIF-1 in Heart Endothelial Cells of Rats that Induces Psychological Stress

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