Influence of Flocculating Agents and Structural Vehicles on the Physical Stability and Rheological Behavior of Nitrofurantoin Suspension

Moghimipour, Eskandar; Salimi, Anayatollah; Rezaee, Saeed; Balack, Maryam; Handali, Somayeh

doi:10.17795/jjnpp-12716

Cited by 8 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The viscosity of suspensions should not be too high to make redispersion difficult [37]. To formulate a physical stable suspension, several approaches can be employed, including controlled particle size, the use of structured vehicles, and the use of flocculating agents [38]. The particle size of suspensions is crucial and must be reduced within certain range during development stage.…”

Section: Drug Repurposing -Advances Scopes and Opportunities In Drug ...mentioning

confidence: 99%

Utilizing 505(b)(2) Regulatory Pathway for New Drug Applications: An Overview on the Advanced Formulation Approach and Challenges

Chen¹,

Zhang²,

Wang³

et al. 2023

Drug Repurposing - Advances, Scopes and Opportunities in Drug Discovery

View full text Add to dashboard Cite

More than 50% of approved drugs on the market contain poorly water-soluble APIs, which typically are associated with poor bioavailability, suboptimal drug delivery, ineffective drug efficacy, and side effects. This creates a huge opportunity in generating 505(b)(2) products, which address unmet medical needs by applying formulation technologies to overcome those difficulties. A key feature of the 505(b)(2) pathway is the 505(b)(2) sponsor can rely upon clinical data or literature produced by other companies. The 505(b)(2) pathway allows manufacturers to acquire FDA approval without performing all the work required with a traditional NDA. The 505(b)(2) strategy can be an option to improve existing drug products with a new indication, dosage form, dosing regimen, strength, combination with other products, new route of administration, elimination of food effect, switching from a prescription drugs (Rx) to an over-the-counter (OTC), non-prescription product that differs from the OTC monograph, and orphan drug indications. Both generic and brand companies are turning to more complex 505(b)(2) products to avoid the commoditized generic competition. Revitalization of older marketed drug products using innovative drug delivery technologies or platforms can provide new marketing exclusivity and new patent protection, and thus offer an effective tool for product life cycle management.

show abstract

Section: Drug Repurposing -Advances Scopes and Opportunities In Drug ...mentioning

confidence: 99%

Utilizing 505(b)(2) Regulatory Pathway for New Drug Applications: An Overview on the Advanced Formulation Approach and Challenges

Chen¹,

Zhang²,

Wang³

et al. 2023

Drug Repurposing - Advances, Scopes and Opportunities in Drug Discovery

View full text Add to dashboard Cite

show abstract

“…The number of rotations (N) needed for complete redispersion was recorded. Redispersion was evaluated by visual observation [19].…”

Section: Degree Of Flocculation β = F / F∞mentioning

confidence: 99%

Evaluation of Antacid Potential of Ayurvedic Poly-Herbal Formulation for Functional Dyspepsia

Kulkarni¹,

Pandit²,

Walke³

et al. 2021

JOCAMR

View full text Add to dashboard Cite

Aim: Ayurveda describes herbal or polyherbal or herbo-mineral medicines such as Avipattikar churna for treatment of Amlapitta, ajirna for centuries. Ayurvedic medicines are associated with limitations namely, palatability, stability and accuracy of dose. Ayurvedic medicines lack in adequate safety and efficacy evidence data. The aim of the study was to develop a stable and palatable Avipattikar suspension using recent formulation and analytical techniques. The study was also aimed at determination of acid neutralizing capacity of Avipattikar suspension and predicting its efficacy for treatment of Functional Dyspepsia and Gastroesophageal Reflux Disorder. Methods: Flocculated Avipattikar suspension was prepared using sodium carboxymethylcellulose (CMC) as the suspending agent, sodium citrate as the flocculating agent, mannitol as a taste masking agent. Sodium carboxymethylcellulose, sodium citrate, Tween 80®, glycerin and mannitol were not used in Deflocculated Avipattikar suspension. The sedimentation volume, degree of flocculation, redispersibility and pH of the suspension was evaluated. The acid neutralization capacity of Avipattikar suspension was determined by Unite States Pharmacopoeia method. Results: The present study successfully demonstrated formulation of stable Avipattikar suspension from Avipattikar churna. The suspendability of sediment was retained for 15 days in presence of CMC. The results indicated that the acid neutralizing capacity of Avipattikar suspension (2.80 mMol of H+/ gm) was similar to that of the marketed antacid suspension (2.756 mMol of H+/ gm). The unpleasant taste of herbal drugs was masked satisfactorily. Conclusion: Avipattikar suspension may be a cheaper, safer and effective alternative for current antacids for the treatment of functional dyspepsia.

show abstract

“…Flocculation is a physical and chemical process used for the removal of the visible sediments and material from water which makes it a colloidal solution. This can be achieved through agitation or by the addition of flocculating agents [8]. Chemical flocculants include clarifying agents such as Iron (II) sulphate, Aluminium sulphate, and Iron (II) chloride in water treatment which results in the formation of colloids [9].…”

Section: Introductionmentioning

confidence: 99%

Comparative Effects of Conventional and Non-Conventional Flocculants and Disinfectants on Microbial Contaminants in Water Purification

Omiyale

Ekundayo

2019

JAMB

View full text Add to dashboard Cite

This work compares the effect of alum, a conventional flocculant to the bioflocculant isolated from Bacillus subtilis and Moringa oleifera seed powder (non conventional bioflocculants) and chlorine as disinfectant on microbial contaminants in water purification. Bioflocculant was purified from the sand sediments of Onyearugbulem market, jar test method was used in bioflocculating activity and dosage. Bioflocculant purified from Bacillus subtilis isolated from the sediments of Onyearugbulem market stream inhibited the growth of coliform for well, stream and abattoir waste water samples. On the other hand, alum sulfate when compared with bioflocculant at a dosage level of 200 mg for well and stream waters and 800 mg for abattoir waste water yielded flocculating activities of 87.33%, 78.42% and 24.60%. This indicates that purified bioflocculant was more effective than alum sulphate. Bioflocculant produced from Bacillus subtilis should be exploited in water treatment. Moringa oleifera seed powder exhibited both flocculating and disinfecting potentials in water treatment but not effective in the treatment of abattoir waste water.

show abstract

Influence of Flocculating Agents and Structural Vehicles on the Physical Stability and Rheological Behavior of Nitrofurantoin Suspension

Cited by 8 publications

References 14 publications

Utilizing 505(b)(2) Regulatory Pathway for New Drug Applications: An Overview on the Advanced Formulation Approach and Challenges

Utilizing 505(b)(2) Regulatory Pathway for New Drug Applications: An Overview on the Advanced Formulation Approach and Challenges

Evaluation of Antacid Potential of Ayurvedic Poly-Herbal Formulation for Functional Dyspepsia

Comparative Effects of Conventional and Non-Conventional Flocculants and Disinfectants on Microbial Contaminants in Water Purification

Contact Info

Product

Resources

About