Influence of flumequine and oxytetracycline on the resistance of the European eel against the parasitic swimbladder nematode Anguillicola crassus

Heijden, M.H.T. van der; Helders, G.M.; Booms, G.H.R.; Huisman, E.A.; Rombout, J.H.W.M.; Boon, J.H.

doi:10.1016/0165-2427(95)05532-0

Cited by 7 publications

(4 citation statements)

References 16 publications

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“…Lymphocytosis was also reported in A. anguilla treated with CAP (Kreutzmann, 1977). Antibiotics-induced lymphocytosis was found in rainbow trout, O. mykiss given oral administration of florfenicol (Lundén et al, 1999) and in A. anguilla treated with flumequine ( Van der Heijden et al, 1996). On the contrary, lymphocytopenia was observed in O. mykiss and in C. carpio treated with OTC and AO (Lundén et al, 1998;Rijkers et al, 1980).…”

Section: Discussionmentioning

confidence: 76%

“…OTC and oxonilic acid (AO) suppress total WBC in Oncorhynchus mykiss (Lundén et al, 1998). Similarly, flunequine had a mitogenic effect in eel, Anguilla anguilla ( Van der Heijden et al, 1996). Kreutzmann (1977) observed that CAP and OTC administration resulted in erythropoietic perturbation in eel A. anguilla, through decreased number of erythroblasts and dysfunctional erythrocyte metabolism.…”

Section: Introductionmentioning

confidence: 91%

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Changes in behavior and hematological parameters of freshwater African catfishClarias gariepinus(Burchell 1822) following sublethal exposure to chloramphenicol

Nwani

Mkpadobi

Onyishi

et al. 2013

Drug and Chemical Toxicology

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The present study was aimed at evaluating the effects of different concentrations of the most commonly used fish antimicrobial drug, chloramphenicol (CAP), on the behavior and hematological parameters of Clarias gariepinus. Fish specimens were exposed to three (2.5, 5.0 and 10.0 mg L(-1)) sublethal concentrations of CAP and a control. Abnormal behavioral changes were observed in fish exposed to higher concentration of CAP. Blood erythrocytes were sampled on days 1, 5, 10 and 15 postexposure to evaluate hematological parameters. Results showed concentration- and time-dependent significant increase in packed cell volume after day 5 of exposure (p < 0.05). Hemoglobin values also significantly decreased from day 5, whereas values of mean cellular volume significantly decreased throughout the experimental period (p < 0.05). A mixed trend was observed in the mean values of red blood cells, white blood cells, mean cellular hemoglobin and mean cellular hemoglobin concentration as well as neutrophils. Activities of lymphocytes were significantly increased in all CAP-treated fish during the exposure period, whereas no significant differences were observed in values of monocytes, eosinophils and basophils among the treatment groups and control. Consequently, precautions must be taken, especially when high concentrations of CAP are used in long-term treatments of C. gariepinus in aquaculture.

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Section: Discussionmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 91%

Changes in behavior and hematological parameters of freshwater African catfishClarias gariepinus(Burchell 1822) following sublethal exposure to chloramphenicol

Nwani

Mkpadobi

Onyishi

et al. 2013

Drug and Chemical Toxicology

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“…found that splenic enlargement in wild European eels correlated with the number of A. crassus in the swimbladder lumen and with the severity of swimbladder damage, suggesting an increased synthesis of immune cells. From haematological studies performed with naturally infected and experimentally infected European eels, it appeared that A. crassus infection causes an increasing granulocyte number (Boon et al, 1990b;Hö glund et al, 1992a;Van der Heijden et al, 1996), giving evidence for cellular immune reactions. However, this result could not be confirmed by Boon et al (1990a) and Palíková & Navrátil (2001).…”

Section: Cellular Immune Responsementioning

confidence: 99%

The swimbladder nematode Anguillicola crassus in the European eel Anguilla anguilla and the Japanese eel Anguilla japonica: differences in susceptibility and immunity between a recently colonized host and the original host

Knopf

2006

J. Helminthol.

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The swimbladder nematode Anguillicola crassus originates from Asia where it is a parasite of the Japanese eel Anguilla japonica. After its introduction to Europe about 25 years ago, the parasite spread rapidly within the indigenous populations of the European eel Anguilla anguilla and subsequently the prevalence and mean intensity appeared to stabilize. Under experimental and aquaculture conditions the naïve new host appears to be more susceptible to A. crassus compared to the original host. Both eel species develop a immune response against A. crassus. The antibody response is well characterized for the European eel, but poorly characterized for the Japanese eel. It remains unclear if antibodies have any protective function against A. crassus. Encapsulation of larvae of A. crassus can be observed in naturally infected European eels. However, encapsulation of larvae following experimental infection has not been detected in European eels, but only in Japanese eels. Reinfection experiments and intraperitoneal injection of A. crassus homogenates failed to demonstrate the development of acquired immunity in European eels. Immunization with irradiated third stage larvae provided preliminary evidence for acquired immunity against A. crassus in the Japanese eel, but not in the European eel.

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“…LPS significantly raised the mean proportion of sIg + cells (B-like lymphocytes), while the effect of Con A could not be demonstrated. On the other hand, results suggested a mitogenic effect of flumequine on sIg ) lymphocytes (T-like lymphocytes), which could be involved in protecting eels against infections with the swimbladder parasite Anguillicola crassus (van der Heijden, Helders, Booms, Huisman, Rombout & Boon 1996).…”

Section: Systemic Immunitymentioning

confidence: 99%

The eel immune system: present knowledge and the need for research

Nielsen

Esteve-Gassent

2006

Journal of Fish Diseases

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The European eel, Anguilla anguilla, is one of the most important warm water fish species cultured in southern Europe and the Mediterranean as well as in northern countries including Germany, the Netherlands and Denmark. The Japanese eel, A. japonica, is an important cultured fish in several Asiatic countries including Japan, China and Taiwan. During recent decades, research has been performed to elucidate the immune response of these species against different pathogens (viruses, bacteria or parasites). Nevertheless, there is very limited information in terms of both cellular and humoral immune responses. This review summarizes the present knowledge relating to the eel immune system and includes new data.

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Influence of flumequine and oxytetracycline on the resistance of the European eel against the parasitic swimbladder nematode Anguillicola crassus

Cited by 7 publications

References 16 publications

Changes in behavior and hematological parameters of freshwater African catfishClarias gariepinus(Burchell 1822) following sublethal exposure to chloramphenicol

Changes in behavior and hematological parameters of freshwater African catfishClarias gariepinus(Burchell 1822) following sublethal exposure to chloramphenicol

The swimbladder nematode Anguillicola crassus in the European eel Anguilla anguilla and the Japanese eel Anguilla japonica: differences in susceptibility and immunity between a recently colonized host and the original host

The eel immune system: present knowledge and the need for research

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