2019
DOI: 10.7717/peerj.7049
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Influence of foetal inflammation on the development of meconium aspiration syndrome in term neonates with meconium-stained amniotic fluid

Abstract: Background Meconium-stained amniotic fluid is observed in approximately 10–15% of all deliveries; however, only 5% of neonates with meconium-stained amniotic fluid develop meconium aspiration syndrome (MAS). Although foetal distress and subsequent sympathetic stimulation have been considered as the primary upstream events of MAS, this clinical complication sometimes occurs due to other pathologies, such as intraamniotic inflammation. The aim of this study was to investigate whether the incidence of MAS is asso… Show more

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Cited by 11 publications
(19 citation statements)
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“…An alternative standard classification scale, or the Amsterdam Placental Workshop Group Consensus State, provides relatively more detailed information regarding the severity and extent of intrauterine inflammation, which may allow the assessment of relationships between the spatial pattern and severity of funisitis and MAS development 40 . In the multivariate model of our study, together with known independent variables for MAS development, such as gestational age, cord blood pH, and mode of delivery [7][8][9][10] , sex was additionally incorporated as one of the covariates based on our preliminary findings, which suggested the dependence of MAS development on sex 16 ; however, this relationship was not observed in the current analysis. Considering that our multivariate model does not fully explain the development of MAS, exploration for key independent variables of MAS should be continued.…”
Section: Discussionmentioning
confidence: 98%
“…An alternative standard classification scale, or the Amsterdam Placental Workshop Group Consensus State, provides relatively more detailed information regarding the severity and extent of intrauterine inflammation, which may allow the assessment of relationships between the spatial pattern and severity of funisitis and MAS development 40 . In the multivariate model of our study, together with known independent variables for MAS development, such as gestational age, cord blood pH, and mode of delivery [7][8][9][10] , sex was additionally incorporated as one of the covariates based on our preliminary findings, which suggested the dependence of MAS development on sex 16 ; however, this relationship was not observed in the current analysis. Considering that our multivariate model does not fully explain the development of MAS, exploration for key independent variables of MAS should be continued.…”
Section: Discussionmentioning
confidence: 98%
“…За даними різних авторів, наявність меконію в навколоплідних водах спостерігається у 10-24 % всіх пологів [1,2,3,4,5,6]. Частота виявлення меконію у навколоплідних водах у 6 разів вища серед жінок з терміном вагітності 42 тижнів або більше порівняно з терміном 37 тижнів.…”
Section: вступunclassified
“…Однак не можна стверджувати однозначно, що гестаційний вік більше 41 тижні слугує незаперечним чинником ризику САМ, адже за результатами дослідження Yokoi K., Iwata O. et al (2019 р. ), гестаційний вік не відрізнявся у новонароджених, в яких розвинувся та не розвинувся САМ [5]. Новонародженим з масою при народженні від 2500 г до 2999 г властива на 33% менша ймовірність вод, забруднених меконієм під час пологів, і вона є ще меншою -7,9% для новонароджених з масою тіла менше 2500 г. Дослідження, проведені Mazor M., Furman B, 1995 р.…”
Section: вступunclassified
“…Adverse conditions could lead to abortion, stillbirth, foetal distress, neonatal respiratory distress, neonatal sepsis, and even death after birth. 5 , 6 , 7 Therefore, as a disease with rapid progress and high mortality, it is critical to predict the possibility of neonatal ARDS using perinatal factors prior to delivery. However, thus far, there remain few reports on the correlation between perinatal factors and neonatal ARDS, and no risk prediction model of perinatal factors has been established to predict the occurrence of neonatal ARDS.…”
Section: Introductionmentioning
confidence: 99%