Influence of Foot Ulceration on All-Cause and Cardiovascular Mortality in Diabetic Patients

Abstract

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Patients' Perceptions of Reasons Contributing to Delay in Seeking Help at the Onset of a Diabetic Foot Ulcer

“…While individuals with regulated DM can expect to live as long as a person without the condition, persons with poorly controlled diabetes may experience life-threatening complications such as diabetic foot ulcers (DFUs), decreased productivity, reduced health-related quality of life, and premature death 2,3. In addition, a recent retrospective case-control study reported that individuals with DFU have high risk for all-cause of and cardiac-related deaths than a match group of individuals with DM alone 4…”

Global mortality of diabetic foot ulcer: A systematic review and meta‐analysis of observational studies

“…The result of assessment of risk of bias is presented in Table S2. Twenty‐three studies 9‐31 had a low risk of bias, and five studies 32‐36 had a moderate risk of bias. Six studies were identified as having a serious risk of bias.…”

“…Kaplan–Meier was used to describe the survival of DFU in 28 of the included studies 9,10,12‐21,23‐25,27,29‐38,40,41 . Of these studies, the number at risk and survival proportions could be estimated in 27 studies 9,10,12‐21,23‐25,27,29‐31,33‐38,40,41 .…”

“…10,21,[23][24][25]29,30,34,39,42,43 Of the 1637 deaths, cardiovascular diseases, including cerebrovascular diseases, accounted for nearly half (46.6%, 95% CI 33.5%-59.7%) (Figure 4A). 10,21,[23][24][25]29,30,34,39,42,43 Infection was the second most common cause of death, with a pooled proportion of 24.8% (95% CI 16.0%-33.5%) (Figure 4B). 10, [23][24][25]30,34,42,43 The reported infections included sepsis, respiratory infection and foot infection.…”

“…Kaplan-Meier was used to describe the survival of DFU in 28 of the included studies. 9,10,[12][13][14][15][16][17][18][19][20][21][23][24][25]27,[29][30][31][32][33][34][35][36][37][38]40,41 Of these studies, the number at risk and survival proportions could be estimated in 27 studies. 9,10,[12][13][14][15][16][17][18][19][20][21][23][24][25]27,[29][30][31][33][34][35][36][37]…”