Documented 6-way (Groups 2, 4, 5, 9, 14, and 27) and 5-way (Groups 2, 5, 9, 14, and 27) multiple-herbicide-resistant (MHR) waterhemp have been confirmed in the US and Canada, respectively causing corn and soybean yield losses > 70%. The objective of this study was to determine the effect of acetochlor application timing and rate on non-emerged MHR waterhemp control in corn and soybean. Acetochlor is not yet registered in Canada, but it could be useful component of an integrated MHR waterhemp control program. Two studies, one in corn and one in soybean, were conducted in southwestern Ontario, Canada from 2020 to 2022. Three rates of acetochlor were applied preplant (PP), preemergence (PRE) and postemergence (POST) to non-emerged waterhemp. In corn, acetochlor [Emulsifiable Concentrate (EC)] applied at 1,225, 2,100 and 2,950 g ai ha-1 controlled MHR waterhemp 81, 85, and 90%, respectively, at 8 weeks after POST application (WAC). Acetochlor EC applied POST or PRE provided better control than when applied PP at 4, 8, and 12 WAC. In soybean, acetochlor [Capsule suspension (CS)] applied at 1,050, 1,375, and 1,700 g ai ha-1 controlled MHR waterhemp 63, 70, and 74%, respectively, at 8 WAC. The timing of acetochlor CS application did not affect MHR waterhemp control. Acetochlor applied at the low, medium, and high rate reduced waterhemp density by 87, 89, and 92% in corn, and by 82, 84, and 87% in soybean, respectively. The high rate of acetochlor provides acceptable control of MHR waterhemp in corn; control in soybean was inadequate.