Influence of four commercial porcine circovirus type 2 (PCV2) vaccines on the improvement of production parameters in pigs with maternally derived antibodies

Villa-Mancera, Abel; Hernández-Guzmán, Karina; Olivares-Pérez, Jaime; Molina-Mendoza, Pedro

doi:10.1016/j.livsci.2016.05.013

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…From these papers, 10 were excluded based on in-/exclusion criteria. Accordingly, 13 articles [ 4 , 5 , 7 , 8 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ] were finally considered for data collection ( Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

Do High Levels of Maternally Derived Antibodies Interfere with the Vaccination of Piglets against Porcine Circovirus Type 2? A Literature Review and Data Analysis

et al. 2021

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Vaccination against porcine circovirus type 2 (PCV2) is commonly performed in piglets worldwide, and increasingly also in sows. We conducted a literature search and review to assess the potential interference of maternally derived antibodies (MDA) in piglets with vaccination against PCV2. The effectiveness of vaccination was compared to no vaccination in the presence of high levels of MDA (≥8 log2 IPMA titer), as reported in field studies. In total, 13 papers fulfilled the predefined inclusion criteria, allowing up to 24 comparisons per parameter. In the presence of high levels of MDA, vaccinated pigs had, on average, a 20 g/d higher mean daily weight gain and a 34% lower mortality compared to non-vaccinates. The maximum percentage of viremic pigs was reduced by 63% and the maximum viral load in serum was 0.72 log10 PCV2 DNA copies lower. Vaccination at 3 weeks of age was associated with the highest improvements in production parameters and reductions in viremia. Our findings suggest that the vaccination of piglets is effective with respect to production parameters and viremia even in the presence of high MDA, with an age of 3 weeks at vaccination being most beneficial.

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Section: Resultsmentioning

confidence: 99%

Do High Levels of Maternally Derived Antibodies Interfere with the Vaccination of Piglets against Porcine Circovirus Type 2? A Literature Review and Data Analysis

et al. 2021

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“…A meta-analysis was published in 2011 comparing the efficacy of PCV2 vaccines at reducing postweaning mortality, which found that vaccination results in an absolute reduction of nursery-finish mortality of 5.4% and reduction of finish mortality of 4.4% ( Kristensen et al, 2011 ). Across field studies identified in this review, the magnitude of impact on absolute mortality associated with PCV2 vaccination ranged from 0% to 24% or up to 75% relative reduction ( Cline et al, 2008 ; Fachinger et al, 2008 ; Horlen et al, 2008 ; Kixmoller et al, 2008 ; Desrosiers et al, 2009 ; Neumann et al, 2009 ; Segales et al, 2009 ; Pejsak et al, 2010 ; Takahagi et al, 2010 ; Jacela et al, 2011 ; Venegas-Vargas et al, 2011 ; Young et al, 2011 ; Fraile et al, 2012 ; Lee et al, 2012 ; Potter et al, 2012 ; Han et al, 2013 ; Heibenberger et al, 2013 ; Sidler et al, 2012 ; Potter et al, 2014 ; Jeong et al, 2015 ; Martelli et al, 2016 ; Villa-Mancera et al, 2016 ; Czyzewska-Dors et al, 2018 ). Herds with high PCV2 antibody titers have been associated with reduced grow-finish performance (combined ADG, G:F, mortality, and carcass weight) compared to herds with lower PCV2 titers ( Fablet et al, 2018 ).…”

Section: Resultsmentioning

confidence: 99%

Postweaning mortality in commercial swine production II: review of infectious contributing factors

Gebhardt

Tokach

Dritz

et al. 2020

Translational Animal Science

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Postweaning mortality is extremely complex with a multitude of noninfectious and infectious contributing factors. In the current review, our objective is to describe the current state of knowledge regarding infectious causes of postweaning mortality, focusing on estimates of frequency and magnitude of effect where available. While infectious mortality is often categorized by physiologic body system affected, we believe the complex multifactorial nature is better understood by an alternative stratification dependent on intervention type. This category method subjectively combines disease pathogenesis knowledge, epidemiology, and economic consequences. These intervention categories included depopulation of affected cohorts of animals, elimination protocols using knowledge of immunity and epidemiology, or less aggressive interventions. The most aggressive approach to control infectious etiologies is through herd depopulation and repopulation. Historically, these protocols were successful for Actinobacillus pleuropneumoniae and swine dysentery among others. Additionally, this aggressive measure likely would be used to minimize disease spread if either a foreign animal disease was introduced or pseudorabies virus was reintroduced into domestic swine populations. Elimination practices have been successful for Mycoplasma hyopneumoniae, porcine reproductive and respiratory syndrome virus, coronaviruses, including transmissible gastroenteritis virus, porcine epidemic diarrhea virus, and porcine deltacoronavirus, swine influenza virus, nondysentery Brachyspira spp., and others. Porcine circovirus type 2 can have a significant impact on morbidity and mortality; however, it is often adequately controlled through immunization. Many other infectious etiologies present in swine production have not elicited these aggressive control measures. This may be because less aggressive control measures, such as vaccination, management, and therapeutics, are effective, their impact on mortality or productivity is not great enough to warrant, or there is inadequate understanding to employ control procedures efficaciously and efficiently. Since there are many infectious agents and noninfectious contributors, emphasis should continue to be placed on those infectious agents with the greatest impact to minimize postweaning mortality.

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Influence of four commercial porcine circovirus type 2 (PCV2) vaccines on the improvement of production parameters in pigs with maternally derived antibodies

Cited by 2 publications

References 25 publications

Do High Levels of Maternally Derived Antibodies Interfere with the Vaccination of Piglets against Porcine Circovirus Type 2? A Literature Review and Data Analysis

Do High Levels of Maternally Derived Antibodies Interfere with the Vaccination of Piglets against Porcine Circovirus Type 2? A Literature Review and Data Analysis

Postweaning mortality in commercial swine production II: review of infectious contributing factors

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