Influence of fraction size, total dose, and overall time on local control of T1–T2 glottic carcinoma

Hypofractionated accelerated radiotherapy in T1–3 N0 cancer of the larynx: A prospective cohort study with historical controls

“…12,18,[22][23][24][25] In some reports these indicators reach 100%. 2,13,26 The publications on hypofractionated accelerated RT for larynx cancer present results in T1-T2 tumors while in our study T3 tumors were diagnosed in 8% of patients in the H group. In the subgroup of patients with T1-T2 tumors (92% of H group) 5-year OS and PFS were 90%…”

“…[1][2][3][4] It has been estimated that longer RT duration reduces local control of the tumor by 3-25% (median 15%) after 1 week and 5-42% (median 26%) after 2 weeks prolongation. 5 If RT delivery is shortened by 1 week, outcome improves by up to 9%.…”

Three weeks radiotherapy for T1 glottic cancer: the Christie and Royal Marsden Hospital Experience

“…Treatment related parameters that may have an effect on end results include overall treatment time (OTT) [6,16,27,33,40,41,42,49,51], fraction size [20,22,29,43,54] [42]. Even with surgical salvage, the group of patients whose treatment was most prolonged had an increased risk of death from loco-regional progression of disease.…”

“…The effect of fraction size per se in the above studies is difficult to assess, as in nearly all cases those patients who received larger fractions were also treated over shorter times, making it difficult to disentangle fraction size from OTT for a given radiotherapy schedule. Nevertheless, the multivariate analysis by Le et al [22] suggested that OTT and fraction size were both independent prognostic variables for local control. Whatever fractionation schedule is used, the biological effective dose (BED), the total dose in a given time, is an important factor in determining success of radiotherapy.…”

Surgical options in radiotherapy-failed early glottic cancer

“…As promoted by guidelines and medical evidence [5,6], early glottic cancer can be treated either with curative radiotherapy (RT) or with surgery, guaranteeing a comparable overall survival. RT is often preferred as primary treatment because it grants a better anatomical preservation and, thus, functional integrity of the larynx [7][8][9]. However, the risk of local recurrence after primary RT is estimated in literature to be as high as 5-10 % for T1 lesions and 20-40 % for T2 lesions [10].…”