The structure of large biomass circulating fluidized bed (BCFB) boilers is complex, and control schemes for coal-fired boilers cannot be simply applied to biomass boilers. Multivariable coupling and operational disturbances are also common issues. In this study, a state space model of a 130 t/h BCFB boiler was established under different operating conditions. Using the 100% operating point as an example, a model predictive controller was designed and tested under output disturbance and input disturbance conditions. The results show that the predictive control system designed in this study has a fast response speed and good stability.