Influence of GABA and GABA-producing Lactobacillus brevis DPC 6108 on the development of diabetes in a streptozotocin rat model

Marques, Tatiana M.; Patterson, Elaine; Wall, Rebecca; O'Sullivan, Órla; Fitzgerald, G.; Cotter, Paul D.; Dinan, Timothy G.; Cryan, John F.; Ross, R. Paul; Stanton, Catherine

doi:10.3920/bm2015.0154

Cited by 49 publications

(35 citation statements)

References 54 publications

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“…In a previous study showed that the γ-aminobutyric acid (GABA)-producing Lactobacillus brevis DPC 6108 and pure GABA has protective effects against the development of diabetes in STZ-induced diabetic Sprague Dawley rats. In this study, glucose levels were decreased in diabetic rats receiving L. brevis DPC 6108, compared with diabetic controls (Marques et al, 2016). In addition, oral administration of L. paracasei TD062 induced α-glucosidase inhibitory activity and ameliorated lipid metabolism, oxidative stress, and glucose metabolism (Dang et al, 2018).…”

Section: Tea Polysaccharides As Antidiabetic Supplementmentioning

confidence: 55%

In vivo antidiabetic activities of green and black tea polysaccharides using streptozotocin-induced diabetic mice fed with a high-fat diet

Akalın¹,

Ekiz²,

Karakaya³

et al. 2019

Journal of Food Bioactives

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Type-2 diabetes (T2D) is the most common type of chronic disease in adults and accounts for around 90% of all cases of diabetes. Therefore, developing dietary supplements from natural sources, such as teas, is of great interest. Seven diet groups together with a parallel control group were used for three periods of 16 weeks in total [stabilization period (W-2-W0), model period (W0-W8), and treatment period (W8-W14)]. The primary aim of this study was to investigate the in vivo antidiabetic activities of green and black tea polysaccharides (GTPS and BTPS, respectively) using streptozotocin induced diabetic mice fed with either a high-fat diet (HFD) or normal diet (ND). Streptozotocin and HFD induced T2D in vivo model was developed during the model period (W0-W8) in C57BL/6J male mice. Both GTPS and BTPS groups were administrated for 6 weeks (daily 400 mg/kg body weight) by oral gavage throughout the treatment period (W8-W14). The results showed that BTPS group significantly (P < 0.05) decreased the fasting blood glucose level in diabetic mice even fed with a HFD and improved the insulin resistance. Similar effect was not obtained when GTPS group fed with a HFD. In addition, BTPS group fed with a HFD effectively suppressed the body weight gain despite high energy intake and was more successful than its GTPS counterpart group in healing pathologies of liver and affected plasma blood lipid levels due to streptozotocin and HFD-induced diabetes. The present work suggests that BTPS can be used as an antidiabetic dietary supplement without posing any potential health risk.

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Section: Tea Polysaccharides As Antidiabetic Supplementmentioning

confidence: 55%

In vivo antidiabetic activities of green and black tea polysaccharides using streptozotocin-induced diabetic mice fed with a high-fat diet

Akalın¹,

Ekiz²,

Karakaya³

et al. 2019

Journal of Food Bioactives

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“…Several important physiological functions of GABA have been characterized, such as neurotransmission, induction of hypotension, diuretic effects, antidiabetic, relaxing and tranquilizer effects (Inoue et al, 2003; Marques et al, 2016). In fact, some GABA A -receptor agonist drugs (e.g., benzodiazepines) are important pharmacological agents used for clinical treatment of anxiety (Foster and Kemp, 2006).…”

Section: Biofunctional Foodsmentioning

confidence: 99%

Lactic Acid Bacteria and Bifidobacteria with Potential to Design Natural Biofunctional Health-Promoting Dairy Foods

et al. 2017

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Consumer interest in healthy lifestyle and health-promoting natural products is a major driving force for the increasing global demand of biofunctional dairy foods. A number of commercial sources sell synthetic formulations of bioactive substances for use as dietary supplements. However, the bioactive-enrichment of health-oriented foods by naturally occurring microorganisms during dairy fermentation is in increased demand. While participating in milk fermentation, lactic acid bacteria can be exploited in situ as microbial sources for naturally enriching dairy products with a broad range of bioactive components that may cover different health aspects. Several of these bioactive metabolites are industrially and economically important, as they are claimed to exert diverse health-promoting activities on the consumer, such as anti-hypertensive, anti-inflammatory, and anti-diabetic, anti-oxidative, immune-modulatory, anti-cholesterolemic, or microbiome modulation. This review aims at discussing the potential of these health-supporting bacteria as starter or adjunct cultures for the elaboration of dairy foods with a broad spectrum of new functional properties and added value.

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“…Lactobacilli have the necessary capacity to produce GABA and do to varying extents depending upon the individual strain and the environment. Indeed, the GABA-producing Lactobacillus brevis DPC 6108 strain has recently been shown to alter the development of diabetes in a streptozotocin rat (Marques et al, 2016).…”

Section: Microbiota and Humoral Responsesmentioning

confidence: 99%

Microbes, Immunity, and Behavior: Psychoneuroimmunology Meets the Microbiome

Dinan

Cryan

2016

Neuropsychopharmacol

201

121

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There is now a large volume of evidence to support the view that the immune system is a key communication pathway between the gut and brain, which plays an important role in stress-related psychopathologies and thus provides a potentially fruitful target for psychotropic intervention. The gut microbiota is a complex ecosystem with a diverse range of organisms and a sophisticated genomic structure. Bacteria within the gut are estimated to weigh in excess of 1 kg in the adult human and the microbes within not only produce antimicrobial peptides, short chain fatty acids, and vitamins, but also most of the common neurotransmitters found in the human brain. That the microbial content of the gut plays a key role in immune development is now beyond doubt. Early disruption of the host-microbe interplay can have lifelong consequences, not just in terms of intestinal function but in distal organs including the brain. It is clear that the immune system and nervous system are in continuous communication in order to maintain a state of homeostasis. Significant gaps in knowledge remain about the effect of the gut microbiota in coordinating the immune-nervous systems dialogue. However, studies using germ-free animals, infective models, prebiotics, probiotics, and antibiotics have increased our understanding of the interplay. Early life stress can have a lifelong impact on the microbial content of the intestine and permanently alter immune functioning. That early life stress can also impact adult psychopathology has long been appreciated in psychiatry. The challenge now is to fully decipher the molecular mechanisms that link the gut microbiota, immune, and central nervous systems in a network of communication that impacts behavior patterns and psychopathology, to eventually translate these findings to the human situation both in health and disease. Even at this juncture, there is evidence to pinpoint key sites of communication where gut microbial interventions either with drugs or diet or perhaps fecal microbiota transplantation may positively impact mental health.

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Influence of GABA and GABA-producing Lactobacillus brevis DPC 6108 on the development of diabetes in a streptozotocin rat model

Cited by 49 publications

References 54 publications

In vivo antidiabetic activities of green and black tea polysaccharides using streptozotocin-induced diabetic mice fed with a high-fat diet

In vivo antidiabetic activities of green and black tea polysaccharides using streptozotocin-induced diabetic mice fed with a high-fat diet

Lactic Acid Bacteria and Bifidobacteria with Potential to Design Natural Biofunctional Health-Promoting Dairy Foods

Microbes, Immunity, and Behavior: Psychoneuroimmunology Meets the Microbiome

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