Influence of Gemfibrozil and Clofibrate on Metabolism of Cholesterol and Plasma Triglycerides in Man

Ya, Kesäniemi

doi:10.1001/jama.1984.03340410049031

Cited by 133 publications

(41 citation statements)

References 33 publications

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“…20 -21 There is evidence that the increased fractional catabolic rate of VLDLs is quantitatively more important than their reduced synthesis. 22 Grundy and Vega 21 have emphasized the LPL-raising effect of the fibrates and suggested that it may be the most important mechanism by which these drugs promote the catabolism of VLDL. However, the present data do not indicate that increased LPL activity is the main mechanism by which gemfibrozil reduces postprandial lipemia.…”

Section: Discussionmentioning

confidence: 99%

Gemfibrozil reduces postprandial lipemia in non-insulin-dependent diabetes mellitus.

Syvänne

Vuorinen-Markkola

Hilden

et al. 1993

Arterioscler Thromb

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The effect of gemfibrozil on postprandial lipoprotein metabolism was investigated in a 12-week, randomized, double-blind, placebo-controlled trial in 20 non-insulin-dependent diabetic patients with moderate hypertrigryceridemia. The patients were given a meal containing 78 g of fat and 345,000 units of vitamin A to label chylomicrons and their remnants. Plasma obtained at various times during the fat-load test was separated into six fractions by gradient-density ultracentrifugation. Gemfibrozil reduced the postprandial triglyceride response, measured as the area under the time-dependent concentration curve, on average by 32% in whole plasma, by 38% in the Svedberg flotation unit (S f ) 1,100-3,200 chylomicron fraction, by 36% in S, 400-1,100 chylomicrons, and by 38% in the S, 60-400 lipoproteins. Retinyl palmitate, a measure of intestinally derived particles, was reduced in plasma by 34%, in S r 1,100-3,200 by 46%, in S, 400-1,100 by 44%, and in S, 60-400 by 37%. All these reductions were significant in comparison with the placebo group. Particles with S r <60 were not significantly affected. In contrast to earlier observations in healthy subjects, no significant negative correlations existed between postprandial lipemia and high density lipoprotein cholesterol or the postheparin lipoprotein lipase activity. The reduction of the potentially atherogenic chylomicron remnants may decrease the risk of atherosclerosis in non-insulin-dependent diabetes mellitus, a hypothesis that awaits testing in prospective studies. 4 Moreover, recent case-control studies 5 -7 have suggested that individuals with angiographically verified coronary artery disease have elevated levels of chylomicron remnants in their postprandial plasma compared with control subjects without coronary lesions. (Arteriosclerosis and Thrombosis 1993;13:286-295) KEY WORDS • non-insulin-dependent diabetes mellitus • chylomicrons • triglyceride-rich lipoproteins • chylomicron remnants • postprandial lipemia • lipid-lowering therapy • fibrates • gemfibrozilThe risk of atherosclerotic vascular disease is markedly increased in non-insulin-dependent diabetes mellitus (NEDDM). Most of this excess morbidity cannot be explained by the conventional risk factors. 8 In general, NIDDM patients have increased fasting levels of TRLs, From the First (M.S.), Second (H.V.-M.), and Third

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Section: Discussionmentioning

confidence: 99%

Gemfibrozil reduces postprandial lipemia in non-insulin-dependent diabetes mellitus.

Syvänne

Vuorinen-Markkola

Hilden

et al. 1993

Arterioscler Thromb

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“…In the absence of PPARa, this change is likely attributable to the greater availability of hepatic TG for VLDL assembly. In humans, the induction of PPARa by fibrates decreases TG levels through decreased production and increased clearance of VLDL (28). The decreased VLDL production may be accounted for by fibrate-induced attenuation of TG synthesis (29).…”

Section: Discussionmentioning

confidence: 99%

Peroxisome proliferator-activated receptor α polymorphisms and postprandial lipemia in healthy men

Tanaka

Ordovas

Delgado-Lista

et al. 2007

Journal of Lipid Research

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“…The cyclic voltammogram of potassium ferrocyanide at poly (gabapentin) modified GCE (solid line in Figure 5) showed that the redox peak current increased than that of bare GCE (dashed line in Figure 5). At the bare GCE the cyclic voltammogram of K 4 Fe(CN) 6 showed a pair of redox peaks, with the anodic peak potential at 264 mV and the cathodic peak potential at 180 mV in 1M KCl. However for the poly (gabapentin) modified GCE a pair of redox waves of K 4 Fe(CN) 6 were observed with greatly increase of the peak current.…”

Section: Effect Of the Poly (Gabapentin) Film Thickness On The Electrmentioning

confidence: 99%

“…At the bare GCE the cyclic voltammogram of K 4 Fe(CN) 6 showed a pair of redox peaks, with the anodic peak potential at 264 mV and the cathodic peak potential at 180 mV in 1M KCl. However for the poly (gabapentin) modified GCE a pair of redox waves of K 4 Fe(CN) 6 were observed with greatly increase of the peak current. The anodic peak potential was located at 260 mV and the cathodic peak potential at 180 mV respectively.…”

Section: Effect Of the Poly (Gabapentin) Film Thickness On The Electrmentioning

confidence: 99%

“…Although gemfibrozil may slightly reduce total and low-density lipoprotein (LDL) cholesterol concentrations, use of gemfibrozil in patients with elevated triglycerides associated with type IV hyperlipidemia often results in significant increases in LDL; LDL concentrations are not significantly affected by gemfibrozil in patients with Type IIb hyperlipidemia (although HDL is significantly increased) 4 . The mechanism of this action is not completely understood but may involve inhibition of peripheral lipolysis; reduced hepatic extraction of free fatty acids, which reduces hepatic triglyceride production; inhibition of synthesis and increased clearance of VLDL carrier, apolipoprotein B, which also reduces VLDL production and according to animal studies, reduced incorporation of longchain fatty acids into newly formed triglycerides, accelerated turnover and removal of cholesterol from the liver (stimulates incorporation of cholesterol precursors into precursors into liver sterols), and increased excretion of cholesterol in the feces [4][5][6][7][8][9] . Gemfibrozil is determined by high performance liquid chromatography (HPLC) [10][11][12][13] , liquid chromatography (LC) 14,15 , gas chromatography (GC) 16 19 , ion exchange 20 , hydrophobicity interaction 21 , and electrostatic interaction [22][23] .…”

Section: Introductionmentioning

confidence: 99%

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Cyclic Voltammetric Studies of Gemfibrozil at Poly (Gabapentin) Film Modified Glassy Carbon Electrode

P¹,

Deepa²,

Naik³

et al. 2012

Int J Pharmceut Chem

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ABSTRACT:A polymerized film of gabapentin was prepared on the surface of a glassy carbon electrode (GCE) in phosphate buffer solution by electropolymerisation method using cyclic voltammetric technique. The poly (gabapentin) film modified glassy carbon electrode was calibrated with standard potassium ferrocyanide solution in 1 M KCl as a supporting electrolyte. This modified electrode used to study the electrochemical behavior of gemfibrozil, a lipid lowering drug in aqueous alcohol medium by cyclic voltammetric technique. It was found that the oxidation peak current of gemfibrozil at the modified GCE was greatly improved compared with that at the bare GCE. The effects of scan rate, pH, supporting electrolyte concentration, % of solvent and concentration of gemfibrozil were examined. With high sensitivity and selectivity, micro molar detection limit, high reproducibility together with ease of preparation and regeneration of the electrode surface make the electrode very stable for the determination of gemfibrozil in pharmaceutical and clinical preparations.

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Influence of Gemfibrozil and Clofibrate on Metabolism of Cholesterol and Plasma Triglycerides in Man

Cited by 133 publications

References 33 publications

Gemfibrozil reduces postprandial lipemia in non-insulin-dependent diabetes mellitus.

Gemfibrozil reduces postprandial lipemia in non-insulin-dependent diabetes mellitus.

Peroxisome proliferator-activated receptor α polymorphisms and postprandial lipemia in healthy men

Cyclic Voltammetric Studies of Gemfibrozil at Poly (Gabapentin) Film Modified Glassy Carbon Electrode

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