Influence of gender, age and renal function on plasma adiponectin level: the Tanno and Sobetsu study

Isobe, Takeshi; Saitoh, Shigeyuki; Takagi, Satoru; Takeuchi, Hiroshi; Chiba, Yu; Katoh, Nobuo; Shimamoto, Kazuaki

doi:10.1530/eje.1.01930

Cited by 174 publications

(154 citation statements)

References 34 publications

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“…Adipocyte culture, animal and human studies consistently point to a suppressive effect of testosterone on serum adiponectin. However, a recent study of 123 Japanese men reported a positive relation between total testosterone levels and serum adiponectin, 33 consistent with our results. The inverse relation between endogenous estrogen and adiponectin has been observed previously in two smaller studies.…”

Section: Discussionsupporting

confidence: 93%

“…One Japanese study reported weak positive correlations between adiponectin and serum creatinine and BUN in 352 women, 45 whereas another reported positive relations for BUN, but not creatinine, in both sexes. 33 Calculated glomerular filtration rate was inversely related to adiponectin in a group of 125 Polish men and women when analyzed together; however, serum creatinine did not contribute significantly to adiponectin levels in sexspecific multivariate analyses. 46 In this cohort, evidence that age-related deterioration of kidney function contributes to higher circulating levels in older adults was weak; adiponectin was not related to serum creatinine in either sex, before or after adjusting for covariates, and was associated with BUN in men only.…”

Section: Discussionmentioning

confidence: 84%

“…Cnop et al 5 reported higher adiponectin levels at older ages for 182 healthy men and women, aged 32-75 years, although they did not observe a sex difference. Other investigators have found significant adiponectin increments with age for men, 33,42,43 but four of six reported no age-adiponectin association for women. 7,33,[42][43][44][45] The differences among these studies may relate to the more modest association of age with adiponectin in women, or to the size and ethnic composition of the study populations.…”

Section: Discussionmentioning

confidence: 84%

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Sex-specific determinants of serum adiponectin in older adults: the role of endogenous sex hormones

2006

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Objective: To assess the sex-specific association of adiponectin with multiple factors thought to influence its levels, with a special emphasis on endogenous sex hormones. Design and methods: A cross-sectional study of determinants of serum adiponectin in 873 men and 673 postmenopausal women, ages 50-92. Factors evaluated include age, body size, fat distribution, lifestyle (exercise, smoking, alcohol intake), insulin resistance, renal function and endogenous sex hormone levels (total and bioavailable testosterone and estradiol). Results: Median serum adiponectin was 50% higher in women than men (Po0.001). In unadjusted analyses, adiponectin was positively related to age, alcohol intake, high-density lipoprotein (HDL) and testosterone, and negatively related to waist girth, body mass index, Homeostasis Model Assessment for Insulin Resistance (HOMA-IR), triglycerides and bioavailable estradiol in both sexes (all Po0.01). Adiponectin was positively related to blood urea nitrogen, a measure of renal function, in men only (Po0.001). Sex-specific multivariate linear regressions adjusting for HDL and triglycerides showed that only age, HOMA-IR and sex hormones independently predicted circulating adiponectin for both men and women. Higher levels of endogenous testosterone and lower bioavailable estradiol concentrations each predicted higher adiponectin; this was true for both sexes, and was not explained by differences in age, adiposity, alcohol intake, insulin resistance or lipoprotein levels. Conclusions: The association of adiponectin with the factors studied here is strikingly similar for men and women. Sex differences in circulating adiponectin levels in older adults cannot be explained by sex hormone regulation.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 84%

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Sex-specific determinants of serum adiponectin in older adults: the role of endogenous sex hormones

2006

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“…We found that the age, gender, insulin resistance and plasma levels of TG, HDL-C, BNP and uric acid influenced the adiponectin level in all participants, which agreed with previous reports. 5,24,25 However, we found that the glucose spike during the OGTT did not affect the plasma adiponectin level, although HOMR-IR (which represents insulin resistance) had an influence on adiponectin. The present results suggest that adiponectin may have a regulatory role in insulin secretion.…”

Section: Discussionmentioning

confidence: 59%

Plasma adiponectin levels predict cardiovascular events in the observational Arita Cohort Study in Japan: the importance of the plasma adiponectin levels

et al. 2012

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As the plasma level of adiponectin is related to metabolic syndrome and cardiovascular events, a low plasma adiponectin level may either cause or trigger cardiovascular disorders. The purpose of this study was to determine whether a low adiponectin level contributes to cardiovascular events, and to investigate the factors influencing adiponectin in the Japanese Arita-cho cohort study.We followed about 2000 subjects in Arita-cho, Saga, Japan as a cohort study, and we enrolled 637 subjects (205 men; 65.1 ± 8.3 years old) who participated in annual health checks from 2005 to 2008 and underwent measurement of the plasma adiponectin level and an oral glucose tolerance test. We monitored the incidence of cardiovascular or cerebrovascular events in these subjects until the end of 2010, discontinuing follow-up at 3 years after the start of enrollment. Subjects with low plasma adiponectin levels (o10.5 ng ml À1 ) had a higher incidence of newly diagnosed cardiovascular diseases such as acute heart failure or acute myocardial infarction than those with high plasma adiponectin levels (X10.5 ng ml À1 ) over an average of 2.95 years of follow-up. Multivariate analysis showed that the adiponectin level was predicted by the following parameters in all subjects: age (b ¼ 0.16), male gender (b ¼ À0.267), homeostasis model assessment of insulin resistance (b ¼ À0.140) and the plasma levels of high-density lipoprotein cholesterol (b ¼ 0.104), uric acid (b ¼ À0.13), triglycerides (b ¼ À0.169) and brain natriuretic peptide (b ¼ 0.151). The difference in plasma glucose before and 120 min after the intake of a 75-g glucose load did not influence the plasma adiponectin level. The plasma adiponectin level is useful for predicting cardiovascular events, and is a measure of the risk of lifestyle-related diseases.

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“…Firstly, a small decline in renal function was found to be associated with increased adiponectin in subjects 65 years and older compared with subjects younger than 65 years. 46 It has also been hypothesized that adiponectin increases as a compensatory mechanism to minimize IR in older adults and restore metabolic normality. 47 Recently, adiponectin resistance at the skeletal muscle has been shown to occur in humans with chronic heart failure.…”

Section: Gender Age Mets and Adiponectinmentioning

confidence: 99%

Factors determining the risk of the metabolic syndrome: is there a central role for adiponectin?

2013

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EK Calton, VS Miller and MJ SoaresBACKGROUND AND OBJECTIVES: The pathogenesis of the metabolic syndrome (MetS) is not well understood. This review is based on the hypothesis that both traditional and emerging risk factors act through adiponectin. SUBJECTS AND METHODS:We conducted a search of the literature using prominent electronic databases and search terms that included in combination: adiponectin, diet, dietary patterns, exercise, metabolic rate, MetS and testosterone. Articles were restricted to studies conducted on adult humans, reported in English and within the time period 2000-2012. RESULTS AND CONCLUSIONS: Both traditional and emerging risk factors associated with the MetS show some evidence of exerting their influence through adiponectin. High-quality randomized controlled trials that alter adiponectin levels are required to further corroborate this hypothesis. INTRODUCTIONThe metabolic syndrome (MetS) represents a clustering of risk factors for cardiovascular disease and type 2 diabetes mellitus (T2DM), which include: hypertension, low high-density lipoproteincholesterol (HDL-C), high triglycerides (TG), high fasting blood glucose (FBG) and abdominal obesity. 1 Obesity and insulin resistance (IR) have long been accepted as having a pivotal role in the etiopathogenesis of the syndrome. 2,3 However, emerging evidence indicates that even after controlling for these variables, there remains a substantial unexplained risk. 2,[4][5][6] Adiponectin, a collagen-like protein was first discovered in 1995 by Dcherer and Lodish, who called it adipocyte complementrelated protein of 30 kDa (Acrp30). 7 At a similar time, three other independent groups discovered adiponectin, calling it adipose most abundant gene transcript 1 (apM1), AdipoQ and gelatinbinding protein of 28 kDa (GBP28). 8 Adiponectin is secreted primarily from adipose tissue into the circulation where highmolecular-weight, medium-molecular-weight and low-molecularweight oligomeric forms exist. 8,9 Total adiponectin as well as the individual oligomeric forms have been associated with health benefits. 9 Consistent links between low adiponectin levels and increased TG, FBG, waist circumference, blood pressure (BP) levels and decreased HDL-C explain its potential role in the etiology of MetS. 2,10 Furthermore, genetic studies have linked adiponectin and MetS in individuals of European descent. 11 Specifically, overall adiposity, abdominal adiposity and IR were influenced by gene loci, which also encode adiponectin. 12 This review discusses both traditional and emerging factors that may influence the prevalence of MetS. Furthermore, the possibility that adiponectin may have an important role in the pathogenesis of the syndrome was evaluated. As there is inconsistency in the literature whether total, high-molecular-weight, mediummolecular-weight or low-molecular-weight adiponectin was measured, 4,13,14 this review discusses adiponectin in general terms. We present a model that emphasizes the flow-through effects of several factors on MetS risk through adi...

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Influence of gender, age and renal function on plasma adiponectin level: the Tanno and Sobetsu study

Cited by 174 publications

References 34 publications

Sex-specific determinants of serum adiponectin in older adults: the role of endogenous sex hormones

Sex-specific determinants of serum adiponectin in older adults: the role of endogenous sex hormones

Plasma adiponectin levels predict cardiovascular events in the observational Arita Cohort Study in Japan: the importance of the plasma adiponectin levels

Factors determining the risk of the metabolic syndrome: is there a central role for adiponectin?

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