Influence of Genetic Polymorphisms Involved in the Hypothalamic–Pituitary–Adrenal Axis and their Interactions with Environmental Factors on Antidepressant Response

Geng, Leiyu; Ye, Dong-Qing; Shi, Yue; Xu, Zhi; Pu, Mengjia; Li, Zan-Yuan; Li, Xiaoli; Li, Yang; Zhang, Zhijun

doi:10.1111/cns.12201

Cited by 15 publications

(20 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Polymorphism rs352428 worsens the response to antidepressant treatment in Caucasians [36]. Interestingly, polymorphisms rs1360780 and rs3800373 were found to have an association with improved outcomes from antidepressant treatment in Caucasian populations in meta-analysis [30], but there was no significant association in an Asian population [37] although the frequency of these alleles is similar in both populations. Lekman et al [38] also found an association of rs4713916 with remission with citalopram treatment in the Caucasian population [38].…”

Section: Fkbp5 and The Hypothalamic-pituitary-adrenal Axismentioning

confidence: 99%

Pharmacogenetics of Antidepressants, A Review of Significant Genetic Variants in Different Populations

Reyes-Barron¹,

Tonarelli²,

Delozier³

et al. 2017

Clin Depress

View full text Add to dashboard Cite

Major depressive disorder is a highly prevalent disease that is challenging to treat, often requiring medication and dose adjustments. Genetic factors play an important role in psychotropic medication responses. However, the translation of pharmacogenetics findings to clinical recommendations with regards to antidepressant responses is still in its early stages. We reviewed recent primary research articles, meta-analyses, and reviews on the pharmacogenetics of antidepressant treatment for major depressive disorder in different populations. We identified eight genes with likely associations with treatment responses and summarized genetic variants most likely to influence treatment responses. We determined the frequency of these variants in Caucasian, Asian, Hispanic, and African American populations. The genes are related to functions in drug metabolism, transport, signalling, stress response, and neuroplasticity. Clinical recommendations already exist for CYP2D6 and CYP2C19 cytochrome P450 drug metabolism genes. The other genes are: ABCB1 with single nucleotide polymorphisms (SNPs) rs2032583 and rs2235015; FKBP5 with SNPs rs1360780, rs3800373, and rs4713916; GNB3 with SNP rs5443; BDNF with SNP rs6265; HTR2A with SNPs rs7997012 and rs6313; and SLC6A4 with polymorphisms 5-HTTLPR and STin2. There is significant variability of the frequencies of these polymorphisms in the different populations we reviewed. There is also variability in the antidepressant responses between populations carrying the same polymorphism in some cases, indicating a likely polygenic influence. Future studies in the pharmacogenetics of antidepressants would benefit from including more subjects from underrepresented ethnic groups and stratifying results.

show abstract

Section: Fkbp5 and The Hypothalamic-pituitary-adrenal Axismentioning

confidence: 99%

Pharmacogenetics of Antidepressants, A Review of Significant Genetic Variants in Different Populations

Reyes-Barron¹,

Tonarelli²,

Delozier³

et al. 2017

Clin Depress

View full text Add to dashboard Cite

show abstract

“…Similarly, Perlis et al (2009) did not report any significant findings in terms of the same SNP and responder or remission status in Caucasian patients who were administered duloxetine over the course of 6 weeks. Geng et al (2014) also did not find any link between the same SNP and response to 8 weeks of treatment with different SSRIs and SNRIs in their Chinese sample.…”

Section: Polymorphisms In Genes Related To the Arginine Vasopressin (mentioning

confidence: 77%

“…greater serum ACTH concentrations. In addition, Geng et al (2014) found a SNP (rs28364032) and related haplotypes within CRHR1 to predict remission after administering various SSRIs and SNRIs, and Chang et al (2015b) found a haplotype within POMC to predict remission status after treatment with escitalopram or mirtazapine. Notably, studies reporting positive findings in terms of the CRH and melanocortin system had a much higher average quality score (7.3 out of 14) when compared to those reporting null-findings (4.5 out of 14), which highlights the need for further research adhering to high standards.…”

Section: Discussionmentioning

confidence: 99%

“…No differences whatsoever were found for the subgroup of their patients undergoing 6 weeks of milnacipran treatment. Geng et al (2014) did not find the same SNP to…”

Section: Polymorphisms In Genes Related To the Arginine Vasopressin (mentioning

confidence: 91%

“…Six studies focused on CRHR1, coding for one of the CRH receptors. Geng et al (2014) in their sample of Chinese patients found one SNP (rs28364032) and three related haplotypes in CRHR1…”

Section: Polymorphisms In Genes Related To the Arginine Vasopressin (mentioning

confidence: 98%

See 2 more Smart Citations

Polymorphisms in genes related to the hypothalamic-pituitary-adrenal axis and antidepressant response – Systematic review

Fischer

Gardini

Haas

et al. 2019

Neuroscience & Biobehavioral Reviews

View full text Add to dashboard Cite

show abstract

Childhood maltreatment experiences and emotion perception in young Chinese adults: Sex as a moderator

Zhao

2022

Stress and Health

View full text Add to dashboard Cite

Men and women seem to perceive and react differently to emotional stimuli and have different susceptibilities to childhood trauma. With a cross-sectional design, this study aimed to investigate whether specific patterns of childhood-maltreatment experiences are associated with specific patterns of emotion perception and the sex differences in this relationship. A total of 173 adults rated valence, arousal, and dominance for 60 pictures (varying in pleasantness, unpleasantness, and neutral emotion) from the International Affective Picture System and completed the Childhood Trauma Questionnaire-Short Form. Using a partial least squares (PLS) regression analysis, after controlling for depressive and anxious states, recent stressful life events, personality, and cognitive reappraisal strategy, we identified a profile (linear combination) of childhood-maltreatment experiences (emotional neglect, physical neglect, and physical abuse) that was associated with a profile of emotion-perception dimensions (perceiving negative visual stimuli as more unpleasant and subservient, positive stimuli as more pleasant and dominant, and neutral stimuli as more arousing). This association pattern was significant only for the male participants. Hence, our findings suggest that childhood maltreatment might make men more "emotional" in their adulthood. The impact of this childhoodmaltreatment-associated alteration in emotion perception on male mental health needs further investigation.

show abstract

Influence of Genetic Polymorphisms Involved in the Hypothalamic–Pituitary–Adrenal Axis and their Interactions with Environmental Factors on Antidepressant Response

Abstract: Our results support a definite role for CRHR1 in the pharmacogenetics of antidepressant drugs. This may contribute to interpatient differences in their responses to antidepressant drugs.

Cited by 15 publications

References 42 publications

Pharmacogenetics of Antidepressants, A Review of Significant Genetic Variants in Different Populations

Pharmacogenetics of Antidepressants, A Review of Significant Genetic Variants in Different Populations

Polymorphisms in genes related to the hypothalamic-pituitary-adrenal axis and antidepressant response – Systematic review

Childhood maltreatment experiences and emotion perception in young Chinese adults: Sex as a moderator

Contact Info

Product

Resources

About