Influence of Genetic Polymorphisms of the Renin-Angiotensin System on IgA Nephropathy

Bantis, Christos; Ivens, Katrin; Kreußer, W.; Koch, Matthias; Klein-Vehne, N.; Grabensee, B; Heering, Peter

doi:10.1159/000077398

Cited by 44 publications

(39 citation statements)

References 51 publications

(74 reference statements)

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“…In accordance with our findings, two earlier studies, including 260 110 and 168 140 Caucasian patients with various non-diabetic renal diseases, reported a deleterious effect of the D allele on loss of renal function only or particularly present in patients with the MM genotype of the angiotensinogen-M235T polymorphism. In contrast, Bantis et al 141 found a negative impact of the combination of D and T alleles on loss of calculated deterioration of renal function in patients with IgA nephropathy (n=44). Studies of single gene effects on the response to RAS blockade in hypertensive patients 129 and in patients with hypertension and left ventricular hypertrophy 142 supports the identification of the M allele of the angiotensinogen-M235T and the A allele of the AT 1 -receptor (A 1166 →C) polymorphisms as risk alleles.…”

Section: Genetic Interaction and Pharmacogenomicsmentioning

confidence: 80%

Preventing end stage renal disease in diabetic patients — genetic aspect (part I)

Jacobsen

2005

J Renin Angiotensin Aldosterone Syst

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Diabetic nephropathy is a major cause of diabetesrelated morbidity and mortality; however the clinical course of the disease and the renal prognosis is highly variable among individuals. The current review will discuss the genetic influence on the development of end stage renal disease (ESRD) in diabetic patients and potential improvements to the current treatment strategy to slow the loss of kidney function in these patients. In this first part, the growing evidence that glucose-induced activation of the intra-renal and systemic renin-angiotensin systems plays an essential role in processes leading to destruction of renal function is summarised. Genetic variations, especially the angiotensin-converting enzyme (ACE)/ID polymorphisms in the gene coding for ACE, are involved in activation of the renin-angiotensin system and seem to influence the clinical course of diabetic nephropathy during treatment with ACE inhibitors. In addition, this polymorphism may interact with other polymorphisms within the reninangiotensin system, leading to high risk of ESRD. As new genetic approaches and methods develop, further understanding of diabetic nephropathy will evolve and genotyping will help prevent ESRD in diabetic patients.

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Section: Genetic Interaction and Pharmacogenomicsmentioning

confidence: 80%

Preventing end stage renal disease in diabetic patients — genetic aspect (part I)

Jacobsen

2005

J Renin Angiotensin Aldosterone Syst

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“…The role of two genes variants of angiotensinogen (AGT) and angiotensin II type-1 receptor (AT1R) and their interaction with ACE I/D polymorphism on the susceptibility to DN has been investigated with controversy (47)(48)(49)(50).…”

Section: Interaction Between Ace I/d and Variants Of Ras Genesmentioning

confidence: 99%

ACE insertion/deletion (I/D) polymorphism and diabetic nephropathy

Rahimi¹

2012

J Nephropathol

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Implication for health policy/practice/research/medical education:The presence of angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism affects the plasma level of ACE. ACE DD genotype is associated with highest systemic and renal ACE levels, compared with the lowest ACE activity in carriers of II genotype. Most studies confirmed that ACE I/D polymorphism is involved in the susceptibility to overt nephropathy with protective role of ACE II genotype against the disease in both type 1 and 2 diabetes mellitus. In this review focus has been performed on the study of ACE I/D polymorphism in various populations and its influence on the risk of onset and progression of diabetic nephropathy. Results:The presence of ACE insertion/deletion (I/D) polymorphism affects the plasma level of ACE. ACE DD genotype is associated with the highest systemic and renal ACE levels compared with the lowest ACE activity in carriers of II genotype. Conclusions: In this review focus has been performed on the study of ACE I/D polymorphism in various populations and its influence on the risk of onset and progression of diabetic nephropathy. Also, association between ACE I/D polymorphism and response to ACE inhibitor and angiotensin II receptor antagonists will be reviewed. Further, synergistic effect of this polymorphism and variants of some genes on the risk of development of diabetic nephropathy will be discussed.Review Article

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“…[3,11,12,13] DD genotype has been postulated as a risk factor in renal diseases. DD genotype has been shown to be associated with FSGS with declining renal function.…”

Section: Discussionmentioning

confidence: 99%

Angiotensin converting enzyme gene polymorphism in Indian children with steroid sensitive nephrotic syndrome

Agrawal¹,

Patil²,

Gulati³

et al. 2005

Indian J Med Sci

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Influence of Genetic Polymorphisms of the Renin-Angiotensin System on IgA Nephropathy

Cited by 44 publications

References 51 publications

Preventing end stage renal disease in diabetic patients — genetic aspect (part I)

Preventing end stage renal disease in diabetic patients — genetic aspect (part I)

ACE insertion/deletion (I/D) polymorphism and diabetic nephropathy

Angiotensin converting enzyme gene polymorphism in Indian children with steroid sensitive nephrotic syndrome

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