Influence of Genetics on the Secondary Metabolites of Plants

Jadaun, Jyoti Singh; Yadav, Radha; Yadav, Nisha; Bansal, Shilpi; Sangwan, Neelam S.

doi:10.1007/978-3-031-18587-8_12

Cited by 8 publications

(8 citation statements)

References 147 publications

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Section: Patents Publishedmentioning

confidence: 99%

“…W. somnifera , “Queen of Ayurveda,” is also known as ashwagandha, Indian Ginseng, Poison Gooseberry, Winter Cherry, and suranjan. The herb is a member of the Solanaceae family and grows wild in Mediterranean wastelands and open areas in Southeast Asia as different chemotypes having varying metabolites in its plant parts (Tuli et al, 2009; Ahmad, Samuel, et al, 2016, Ahmad, Arya, et al, 2016; Jadaun et al, 2022; Mishra et al, 2020; Balkrishna et al, 2023). Ashwagandha has recently been deemed a high priority for mechanistic human study by the US National Center for Complementary and Alternative Medicines (NCCAM).…”

Section: Introductionmentioning

confidence: 99%

“…Some of the most prominent withanolides are withanolide A, Withaferin A, withanone and glycowithanolides having shown promising bioactivities including antitumor and cytotoxic properties (Sangwan & Sangwan, 2014; Siddique et al, 2014; Palliyaguru et al, 2016; Tuli et al, 2009; Sangwan et al, 2017; Jadaun et al, 2022; Sekar et al, 2022). Potential mechanisms utilized here are enhanced expression of tumor suppressor gene p53, induction of apoptosis, down‐regulates the expression of telomerase, regulating signaling pathways, and prevention of skin cancer caused by UV radiation, among others.…”

Section: Introductionmentioning

confidence: 99%

“…Our search has shown that there have been 2383 patents granted on W. somnifera and human health. Several factors including lifestyle choices, genetics, environmental factors, and healthcare measures all influence individual cancer risk (Tuli et al, 2009; Jadaun et al, 2022). Common cancers reported are Skin, Cervical, Prostate, Lung, Colorectal, Breast, Bladder, Endometrial, Kidney, Leukemia, Liver, Melanoma, Non‐Hodgkin, Thyroid, and Osteosarcoma.…”

Section: Introductionmentioning

confidence: 99%

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Phyto‐therapeutic potential of Withania somnifera: Molecular mechanism and health implications

Yadav,

Tripathi,

Sangwan

2024

Phytotherapy Research

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Withania somnifera, the plant named Indian ginseng, Ashwagandha, or winter cherry, has been used since ancient times to cure various health ailments. Withania somnifera is rich in constituents belonging to chemical classes like alkaloids, saponins, flavonoids, phenolic acids, and withanolides. Several chemotypes were identified based on their phytochemical composition and credited for their multiple bioactivities. Besides, exhibiting neuroprotective, immunomodulatory, adaptogenic, anti‐stress, bone health, plant has shown promising anti‐cancer properties. Several withanolides have been reported to play a crucial role in cancer; they target cancer cells by different mechanisms such as modulating the expression of tumor suppressor genes, apoptosis, telomerase expression, and regulating cell signaling pathway. Though, many treatments are available for cancer; however, to date, no assured reliable cure for cancer is made available. Additionally, synthetic drugs may lead to development of resistance in time; therefore, focus on new and natural drugs for cancer therapeutics may prove a longtime effective alternative. This current report is a comprehensive combined analysis upto 2023 with articles focused on bio‐activities of plant Withania somnifera from various sources, including national and international government sources. This review focuses on understanding of various mechanisms and pathways to inhibit uncontrolled cell growth by W. somnifera bioactives, as reported in literature. This review provides a recent updated status of the W. somnifera on pharmacological properties in general and anti‐cancer in particular and may provide a guiding resource for researchers associated with natural product‐based cancer research and healthcare management.

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Section: Patents Publishedmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Phyto‐therapeutic potential of Withania somnifera: Molecular mechanism and health implications

Yadav,

Tripathi,

Sangwan

2024

Phytotherapy Research

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“…Several studies reported and it is often hypothesized that synthetic polyploidization enhanced primary and secondary metabolite production due to chromosome doubling that in uenced the biological activities of the polyploid plants [25,26,27,28,29]. However, one of such reports has proven it as a myth [30].…”

Section: Introductionmentioning

confidence: 99%

Synthetic polyploidization induces enhanced phytochemical profile and biological activities in Thymus vulgaris L. essential oil

Gupta,

Dutta,

Bhattacharya

et al. 2023

Preprint

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Essential oil from Thymus vulgaris L. has valuable therapeutic potential that is highly desired in pharmaceutical, food, and cosmetic industries. Considering these advantages and the rising market demand, induced polyploids were obtained using oryzalin to enhance essential oil yield. However, their therapeutic values were unexplored. So, this study aims to assess the phytochemical content, and antimicrobial, antioxidant, and anti-inflammatory activities of tetraploid and diploid thyme essential oils. Induced tetraploids had 41.11% higher essential oil yield with enhanced thymol and γ-terpinene content than diploid. Tetraploids exhibited higher antibacterial activity against all tested microorganisms. Similarly, in DPPH radical scavenging assay tetraploid essential oil was more potent with half-maximal inhibitory doses (IC50) of 180.03 µg/mL (40.05 µg TE/mg) than diploid with IC50 > 512 µg/mL (12.68µg TE/mg). Tetraploids exhibited more effective inhibition of in vitro catalytic activity of pro-inflammatory enzyme cyclooxygenase-2 (COX-2) than diploids at 50 µg/mL concentration. Furthermore, molecular docking revealed higher binding affinity of thymol and γ-terpinene towards tested protein receptors, which explained enhanced bioactivity of tetraploid essential oil. In conclusion, these results suggest that synthetic polyploidization using oryzalin could effectively enhance the quality and quantity of secondary metabolites and can develop more efficient essential oil-based commercial products using this induced genotype.

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Unlocking nature’s treasure trove: biosynthesis and elicitation of secondary metabolites from plants

Sangwan,

Jha,

Mitra

2024

Plant Growth Regul

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Influence of Genetics on the Secondary Metabolites of Plants

Cited by 8 publications

References 147 publications

Phyto‐therapeutic potential of Withania somnifera: Molecular mechanism and health implications

Phyto‐therapeutic potential of Withania somnifera: Molecular mechanism and health implications

Synthetic polyploidization induces enhanced phytochemical profile and biological activities in Thymus vulgaris L. essential oil

Unlocking nature’s treasure trove: biosynthesis and elicitation of secondary metabolites from plants

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